背景:血凝块由聚集的纤维蛋白和血小板组成,血栓形成是人体对修复受损血管或止血的自然反应。然而,当这个过程异常激活时,比如在机械血泵中,它可以导致过度的血栓形成。因此,如何避免或降低血栓形成的概率是血泵稳定运行的重要指标。
方法:在本文中,模拟拉格朗日粒子跟踪轨迹以研究血泵中的血小板运输。采用正交设计方法,根据三个因素对血栓血泵的设计进行了优化:入口角,出口角,和刀片编号。血泵压力的影响,转速,叶轮出口角,进口角,使用Fluent软件分析血栓形成的刀片数量。通过分析血泵中血小板颗粒的轨迹和流动参数,得出血栓形成潜能,以及血小板泵内血栓滞留时间和压力积聚的统计参数。
结果:当叶轮入口角为30°时,出口角为20°,并且叶片数为6,在正交设计方法中,血栓形成的概率最小,符合血泵性能要求。
结论:这些设计参数可作为优化血泵中半开放式叶轮几何形状的数值指南,并为随后的体外实验提供了理论基础。
BACKGROUND: Blood clots are composed of aggregated fibrin and platelets, and thrombosis is the body\'s natural response to repairing injured blood vessels or stopping bleeding. However, when this process is activated abnormally, such as in a mechanical blood pump, it can lead to excessive thrombus formation. Therefore, how to avoid or reduce the probability of thrombus formation is an important indicator of the stable operation of a blood pump.
METHODS: In this paper, Lagrangian particle tracking trajectories are simulated to study platelet transport in a blood pump. The design of the thrombus blood pump was optimized using an orthogonal design method based on three factors: inlet angle, outlet angle, and blade number. The effect of blood pump pressure, rotational speed, impeller outlet angle, inlet angle, and number of blades on thrombus formation was analysed using Fluent software. The thrombogenic potential was derived by analyzing the trajectory and flow parameters of platelet particles in the blood pump, as well as the statistical parameters of residence time and stress accumulation thrombus in the platelet pump.
RESULTS: When the impeller inlet angle is 30°, the outlet angle is 20°, and the number of blades is 6, the probability of thrombus formation is minimized in the orthogonal design method, aligning with the requirements for blood pump performance.
CONCLUSIONS: These design parameters serve as a numerical guideline for optimizing the geometry of the semi-open impeller in blood pumps and provide a theoretical foundation for subsequent in vitro experiments.