■肝脂肪变性是脂肪性肝病(FLD)的重要病理特征,目前尚无有效的治疗方法。先前的研究表明,铬(Cr)的摄入减少了动物肝脏中的脂质沉积。然而,血液Cr与人类肝脏脂肪变性之间的联系仍然没有定论。
■使用2017-2020年国家健康与营养检查调查(NHANES)的数据,我们进行了横断面分析,包括4,926名参与者。通过振动控制的瞬时弹性成像(VCTE)测量的受控衰减参数(CAP)用于评估肝脏脂肪变性的程度。加权单变量回归,多元线性回归,采用平滑拟合曲线和亚组分析。此外,我们进行了趋势测试,多个插值,和相互作用分析,进行敏感性分析。
■在调整了各种协变量之后,多元线性回归分析显示血Cr与CAP呈显著负相关[β(95%CI)=-5.62(-11.02,-0.21)]。血Cr与CAP的负相关在男性中更为显著,50-59岁,超重,高胆固醇血症,HDL-C≥65mg/dL,HbA1c(5.70-6.10%),HOMA-IR(0.12-2.76),总胆红素(0.30-0.40mg/dL),曾经饮酒的主体。值得注意的是,在吸烟者和非吸烟者中,血液Cr与CAP之间的关系呈U形曲线,血Cr阈值为0.48、0.69μg/L,分别。
■在美国,血Cr与肝脂肪变性之间存在独立的负相关。我们的研究为临床研究人员提供了对肝脂肪变性的前瞻性预防的新见解。
UNASSIGNED: Hepatic steatosis is a significant pathological feature of fatty liver disease (FLD) which is widely spread with no effective treatment available. Previous studies suggest that chromium (Cr) intake reduces lipid deposition in the liver in animals. However, the connection between blood Cr and hepatic steatosis among humans remains inconclusive.
UNASSIGNED: Using the data from the National Health and Nutrition Examination Survey (NHANES) 2017-2020, we performed a cross-sectional analysis, including 4,926 participants. The controlled attenuation parameter (CAP) measured by the vibration controlled transient elastography (VCTE) was used to evaluate the degree of liver steatosis. Weighted univariate regression, multivariate linear regression, smooth fitting curves and subgroup analysis were used. In addition, we carried out trend tests, multiple interpolations, and interaction analyses to conduct sensitivity analyses.
UNASSIGNED: After adjusting with various covariables, multivariate linear regression analysis demonstrated a significant negative correlation between blood Cr and CAP [β (95% CI) = -5.62 (-11.02, -0.21)]. The negative correlation between blood Cr and CAP was more significant in the males, 50-59 years, overweight, hypercholesterolemia, HDL-C ≥ 65 mg/dL, HbA1c (5.70-6.10 %), HOMA-IR (0.12-2.76), total bilirubin (0.30-0.40 mg/dL), ever alcohol consumption subjects. Of note, the relationships between blood Cr and CAP followed a U-shaped curve in the smokers and non-smokers, with blood Cr thresholds of 0.48, 0.69 μg/L, respectively.
UNASSIGNED: There is an independently negative correlation between blood Cr and hepatic steatosis in American. Our study provides clinical researchers with a new insight into the prospective prevention of hepatic steatosis.