背景:尘肺主要是肺部和心血管疾病,其中肺心病(PHD)因其对尘肺患者的生存有重大影响而备受关注。白细胞计数(WCC),红细胞分布宽度(RDW)和血小板参数被认为会影响炎症反应,并可能是各种心血管疾病的预测因子。然而,很少有研究集中在PHD上。
目的:检查基线全血细胞计数参数(WCC,RDW,血小板参数)和尘肺患者发生PHD的风险。
方法:回顾性队列研究。
方法:这是一个单中心,使用职业病医院数据的回顾性队列研究,成都,四川。
方法:将2012年1月至2021年11月的946例尘肺患者纳入研究。女性患者和有PHD的患者,冠心病,高血压性心脏病,心肌病,心力衰竭,肿瘤疾病,多器官功能障碍,基线和随访时间少于6个月的AIDS也被排除。
方法:我们根据患者出院诊断确定PHD。我们构建了Cox比例风险回归模型来评估尘肺中PHD的HR,以及95%CIs。
结果:在多重Cox比例风险回归分析中,高于基线中位数的血小板计数(PLT)和血小板计数(PCT)与尘肺患者的PHD风险增加相关,校正HR为1.52(95%CI1.09~2.12)和1.42(95%CI1.02~1.99),分别。
结论:较高的基线PLT和PCT与尘肺患者的PHD风险较高相关。
BACKGROUND: Pneumoconiosis mostly combines pulmonary and cardiovascular diseases, among which pulmonary heart disease (PHD) is of major concern due to its significant impact on the survival of pneumoconiosis patients. White cell count (WCC), red cell distribution width (RDW) and platelet parameters are thought to affect inflammatory responses and may be predictors of various cardiovascular diseases. However, very few studies have focused on PHD.
OBJECTIVE: To examine the relationship between baseline complete blood count parameters (WCC, RDW, platelet parameters) and the risk of incident PHD in pneumoconiosis patients.
METHODS: A retrospective cohort study.
METHODS: This was a single-centre, retrospective cohort study that used data from an Occupational Disease Hospital, Chengdu, Sichuan.
METHODS: A total of 946 pneumoconiosis patients from January 2012 to November 2021 were included in the study. Female patients and patients who had PHD, coronary heart disease, hypertensive heart disease, cardiomyopathy, heart failure, oncological disease, multiple organ dysfunction, AIDS at baseline and follow-up time of less than 6 months were also excluded.
METHODS: We identified PHD according to the patient\'s discharge diagnosis. We constructed Cox proportional hazard regression models to assess the HR of incident PHD in pneumoconiosis, as well as 95% CIs.
RESULTS: In the multiple Cox proportional hazard regression analysis, platelet count (PLT) and plateletcrit (PCT) above the median at baseline were associated with an increased risk of PHD in pneumoconiosis with adjusted HR of 1.52 (95% CI 1.09 to 2.12) and 1.42 (95% CI 1.02 to 1.99), respectively.
CONCLUSIONS: Higher baseline PLT and PCT are associated with a higher risk of PHD in pneumoconiosis.