重建由老化引起的骨缺损或骨折,创伤和肿瘤切除仍是临床治疗的一大挑战。虽然自体骨移植被认为是金标准,天然骨骼的来源是有限的。近年来,基于生物活性材料的再生疗法已被提出用于骨重建。特别是,大量研究表明,生物活性陶瓷,包括硅酸盐和磷酸盐生物陶瓷表现出优异的骨诱导性和骨传导性,进一步促进骨再生。此外,镁(Mg)元素,作为不可缺少的矿物元素,在促进骨矿化和形成中起着至关重要的作用。在这次审查中,不同类型的含Mg生物陶瓷,包括含Mg的磷酸钙基生物陶瓷(如Mg-羟基磷灰石,镁双相磷酸钙),含镁硅酸钙基生物陶瓷(如Mg2SiO4、Ca2MgSi2O7和掺镁生物玻璃),镁基生物场所,系统地总结了含Mg的金属/聚合物-生物陶瓷复合材料。此外,深入讨论了制造技术及其材料生物学效应。重点介绍了含镁生物陶瓷用于骨修复的临床应用和前景。总的来说,含镁的生物陶瓷被认为是具有优化性能的再生疗法。此外,对其性能和结构进行更深入的双向研究对于满足其临床需求至关重要。
Reconstruction of bone defects or fractures caused by ageing, trauma and tumour resection is still a great challenge in clinical treatment. Although autologous bone graft is considered as gold standard, the source of natural bone is limited. In recent years, regenerative therapy based on bioactive materials has been proposed for bone reconstruction. Specially, numerous studies have indicated that bioactive ceramics including silicate and phosphate
bioceramics exhibit excellent osteoinductivity and osteoconductivity, further promote bone regeneration. In addition, magnesium (Mg) element, as an indispensable mineral element, plays a vital role in promoting bone mineralisation and formation. In this review, different types of Mg-containing
bioceramics including Mg-containing calcium phosphate-based bioceramics (such as Mg-hydroxyapatite, Mg-biphasic calcium phosphate), Mg-containing calcium silicate-based
bioceramics (such as Mg2SiO4, Ca2MgSi2O7 and Mg-doped bioglass), Mg-based biocements, Mg-containing metal/polymer-bioceramic composites were systematacially summarised. Additionally, the fabrication technologies and their materiobiological effects were deeply discussed. Clinical applications and perspectives of magnesium-containing
bioceramics for bone repair are highlighted. Overall, Mg-containing
bioceramics are regarded as regenerative therapy with their optimised performance. Furthermore, more in-depth two-way researches on their performance and structure are essential to satisfy their clinical needs.