生物电子设备,用于治疗的接口神经组织,诊断,或康复目的,依靠小的电极触点,以实现在神经接口高度复杂的通信。可靠的记录和安全的小电极刺激,然而,在使用常规电极金属化时受到限制,要求开发新材料,以实现生物电子学的未来发展。在这项研究中,我们提出了一种通用的方法,用于实现具有高电化学活性表面积的纳米结构铂(nanoPt)涂层,显示有前途的生物相容性和提供低阻抗,高电荷注入能力,和突出的长期稳定性记录和刺激。拟议的电化学制造工艺提供了对纳米Pt沉积的卓越控制,允许实现特定的涂层形态,如小晶粒,金字塔,或者纳米片,并且还可以在经济的工艺条件下放大到晶片级或批量制造。这里证明了纳米Pt作为神经界面涂层的适用性,在体外和体内,在慢性条件下显示出优异的刺激性能。因此,nanoPt作为先进的神经界面涂层提供了有希望的品质,此外,它还扩展到许多应用领域,其中大的(电)化学活性表面积有助于提高效率。
Bioelectronic devices, interfacing neural tissue for therapeutic, diagnostic, or rehabilitation purposes, rely on small electrode contacts in order to achieve highly sophisticated communication at the neural interface. Reliable recording and safe stimulation with small electrodes, however, are limited when conventional electrode metallizations are used, demanding the development of new materials to enable future progress within bioelectronics. In this study, we present a versatile process for the realization of nanostructured platinum (nanoPt) coatings with a high electrochemically active surface area, showing promising biocompatibility and providing low impedance, high charge injection capacity, and outstanding long-term stability both for recording and stimulation. The proposed electrochemical fabrication process offers exceptional control over the nanoPt deposition, allowing the realization of specific coating morphologies such as small grains, pyramids, or nanoflakes, and can moreover be scaled up to wafer level or batch fabrication under economic process conditions. The suitability of nanoPt as a coating for neural interfaces is here demonstrated, in vitro and in vivo, revealing superior stimulation performance under chronic conditions. Thus, nanoPt offers promising qualities as an advanced neural interface coating which moreover extends to the numerous application fields where a large (electro)chemically active surface area contributes to increased efficiency.