在这里，我们讨论了一对患有胆汁铸型肾病（BCN）的已故供体肾脏的成功利用。供体的肾脏供体特征指数（KDPI）为48％，急性肾损伤（AKI）需要连续的肾脏替代疗法。供体胆红素峰值为40.5mg/dL,肾楔形活检显示BCN。两个接受者的移植功能都延迟了长达4周。4个月的活检显示轻度间质纤维化,肾小管萎缩,和胆汁石膏的决议。这些肾脏同种异体移植物显示出胆血性肾病的可逆性过程以及增加先前丢弃的肾脏利用率的潜力。
Here we discuss the successful utilization of a pair of deceased donor kidneys with bile-cast nephropathy. The donor had a kidney donor profile index of 48% and an acute kidney injury requiring continuous renal replacement therapy. Peak donor bilirubin was 40.5 mg/dL, and renal wedge biopsies showed bile-cast nephropathy. Both recipients had delayed graft function lasting up to 4 weeks. The 4-month biopsies showed mild interstitial fibrosis, tubular atrophy, and a resolution of bile casts. These kidney allografts showed the reversible course of cholemic nephropathy and the potential for increasing the utilization of previously discarded kidneys.
