■有限公司在中国的苹果过敏概况中广为人知。
■探讨中国北方苹果过敏原成分的临床意义。
■这项研究招募了40名参与者,分为苹果耐受性(n=19)和过敏(n=21)组。后者被归类为口腔过敏症状(OAS,n=14)和全身症状(GS,n=7)。所有参与者都接受了ImmunoCAP筛查,以评估桦树的sIgE水平,苹果,和他们的组件。
■Betv1的致敏率为90%,Mald1的致敏率为85%,Betv2的致敏率为35%,Mald3的致敏率为20%。苹果过敏原总体阳性率为97.5%,其中一半显示出对Mald1的单一敏感性。桦木,在诊断苹果过敏时,Betv1和Mald1sIgE水平的曲线下面积一致(AUC0.747,p=0.037;AUC0.799,p=0.012;AUC0.902,p<0.001)。最佳临界值确定为22.85kUA/L(灵敏度为63.6%,85.7%特异性),6.84kUA/L(灵敏度81.8%,71.4%的特异性)和1.61kUA/L(93.8%的灵敏度,75.0%特异性),分别。没有过敏原或成分在区分OAS和GS方面具有诊断价值。Mald3致敏与艾草过敏和桃子的高风险相关,坚果或豆类全身过敏。
■Mald1是主要的过敏原,是诊断苹果过敏的最佳方法。Mald3不一定表明中国北方对苹果的严重过敏反应,但可能表明艾草致敏和桃子风险增加,坚果或豆类过敏。
UNASSIGNED: Limited is known on the profiles of apple allergy in China.
UNASSIGNED: To explore the clinical significance of apple allergen components in northern China.
UNASSIGNED: This study recruited 40 participants and categorized into apple tolerance (n = 19) and allergy (n = 21) group. The latter was categorized into oral allergy symptoms (OAS, n = 14) and generalized symptoms (GS, n = 7). All participants underwent ImmunoCAP screening to assess sIgE levels of birch, apple, and their components.
UNASSIGNED: The sensitization rates were 90% for Bet v 1, 85% for Mal d 1, 35% for Bet v 2, and 20% for Mal d 3. The overall positive rate for apple allergens was 97.5%, with half demonstrating mono-sensitization to Mal d 1. Birch, Bet v 1 and Mal d 1 sIgE levels had consistent areas under the curve (AUC 0.747, p = 0.037; AUC 0.799, p = 0.012; AUC 0.902, p < 0.001 respectively) in diagnosing apple allergy. The optimal cut-off values were determined to be 22.85 kUA/L (63.6% sensitivity, 85.7% specificity), 6.84 kUA/L (81.8% sensitivity, 71.4% specificity) and 1.61 kUA/L (93.8% sensitivity, 75.0% specificity), respectively. No allergens or components demonstrated diagnostic value in distinguishing between OAS and GS. Mal d 3 sensitization was correlated with mugwort allergy and higher risk of peach, nuts or legumes generalized allergy.
UNASSIGNED: Mal d 1 was major allergen and the best for diagnosing apple allergy. Mal d 3 does not necessarily indicate severe allergic reaction to apples in northern China but may indicate mugwort sensitization and an increased risk of peach, nuts or legumes allergy.