目的:尽管发病年龄被认为是影响克罗恩病预后的重要因素,关于它对肠道白塞病(BD)患者长期预后的影响知之甚少。本研究旨在根据发病年龄评估肠道BD患者的长期临床预后。
方法:在<18、18-60和>60岁被诊断为肠道BD的患者被分类为早发性,成年发病,和迟发性群体,分别。疾病发病时间对临床预后的影响,包括特定的医疗要求,BD相关的肠道手术,住院治疗,和急诊室探视,在大量肠道BD患者中使用对数秩检验进行比较。
结果:在780名患者中,21(2.7%),672(86.2%),87例(11.1%)包括早发,成年发病,和迟发性群体,分别。早发型组的患者比成年发作组的患者更可能需要免疫抑制剂(P=0.048)。九(42.9%),158(23.5%),和18(20.7%)患者在早期发作,成年发病,和迟发性群体,分别,接受肠切除术。早发型组的肠切除风险高于晚发型组(P=0.043)和成年发型组(P=0.030)。迟发性组的BD相关住院风险高于成人组(P=0.023)。
结论:诊断年龄影响肠道BD的临床病程,包括肠道手术,住院治疗,和特定的医疗要求。应根据诊断时的年龄制定不同的治疗策略。
OBJECTIVE: Although age at disease onset is considered to be a significant factor in the prognosis of Crohn\'s disease, little is known about its influence on the long-term prognosis of those with intestinal Behçet\'s disease (BD). This study aimed to evaluate the long-term clinical outcomes of patients with intestinal BD according to age of disease onset.
METHODS: Patients diagnosed with intestinal BD at < 18, 18-60, and > 60 years of age were classified into early-onset, adult-onset, and late-onset groups, respectively. The influence of disease onset time on clinical prognosis, including specific medical requirements, BD-related intestinal surgery, hospitalization, and emergency room visits, was compared using the log-rank test in a large cohort of patients with intestinal BD.
RESULTS: Among 780 patients, 21 (2.7%), 672 (86.2%), and 87 (11.1%) comprised the early-onset, adult-onset, and late-onset groups, respectively. Patients in the early-onset group were more likely to require immunosuppressants than those in the adult-onset group (P = 0.048). Nine (42.9%), 158 (23.5%), and 18 (20.7%) patients in the early-onset, adult-onset, and late-onset groups, respectively, underwent intestinal resection. The early-onset group exhibited a higher risk for intestinal resection than the late-onset (P = 0.043) and adult-onset (P = 0.030) groups. The late-onset group exhibited a higher risk for BD-related hospitalization than the adult-onset group (P = 0.023).
CONCLUSIONS: Age at diagnosis affected the clinical course of intestinal BD, including intestinal surgery, hospitalization, and specific medical requirements. Different treatment strategies should be established according to age at diagnosis.