背景:尽管妇女避孕方法广泛,意外怀孕率仍然很高(美国为45%),50%导致流产。目前,全球20%的避孕药具使用是男性主导的,由于可用性有限和缺乏疗效,各国之间差异很大。全球研究表明,>50%的男性会选择使用可逆的方法,90%的女性会依靠她们的伴侣使用避孕药具。新型男性避孕方法可用的其他原因包括预期寿命延长,在伴侣之间分担生殖风险,社会问题,缺乏制药行业的参与,也缺乏倡导男性避孕的舆论制造者。
目的:本指南旨在回顾男性避孕的现状,支持临床实践的最新技术,建议对新的男性避孕药具发展的最低要求,并提供和等级更新,欧洲男科学会(EAA)和美国男科学会(ASA)的循证建议。
方法:由EAA和ASA任命的院士专家小组根据等级(建议的等级,评估,开发和评估)系统。
结果:以夫妻为中心的交流产生了60项基于证据和分级的建议,行为,屏障方法,精液分析和避孕功效,物理代理,手术方法,在开始男性避孕之前的行动,荷尔蒙的方法,非荷尔蒙的方法,疫苗,以及社会和道德方面的考虑。
结论:随着性别角色的转变和性别平等在人际关系中的确立,必须促进男性对计划生育的贡献。必须评估有效和安全的男性导向方法,并将其引入临床实践。最好是可逆的,荷尔蒙或非荷尔蒙。从未来的角度来看,识别新的荷尔蒙组合,合适的睾丸目标,和新出现的血管闭塞方法将产生新的分子和产品的男性避孕。
BACKGROUND: Despite a wide spectrum of contraceptive methods for women, the unintended pregnancy rate remains high (45% in the US), with 50% resulting in abortion. Currently, 20% of global contraceptive use is male-directed, with a wide variation among countries due to limited availability and lack of efficacy. Worldwide studies indicate that >50% of men would opt to use a reversible method, and 90% of women would rely on their partner to use a contraceptive. Additional reasons for novel male contraceptive methods to be available include the increased life expectancy, sharing the reproductive risks among partners, social issues, the lack of pharma industry involvement and the lack of opinion makers advocating for male contraception.
OBJECTIVE: The present guidelines aim to review the status regarding male contraception, the current state of the art to support the clinical practice, recommend minimal requirements for new male contraceptive development and provide and grade updated, evidence-based recommendations from the European Society of Andrology (EAA) and the American Society of Andrology (ASA).
METHODS: An expert panel of academicians appointed by the EAA and the ASA generated a consensus guideline according to the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) system.
RESULTS: Sixty evidence-based and graded recommendations were produced on couple-centered communication, behaviors, barrier methods, semen analysis and contraceptive efficacy, physical agents, surgical methods, actions before initiating male contraception, hormonal methods, non-hormonal methods, vaccines, and social and ethical considerations.
CONCLUSIONS: As gender roles transform and gender equity is established in relationships, the male contribution to family planning must be facilitated. Efficient and safe male-directed methods must be evaluated and introduced into clinical practice, preferably reversible, either hormonal or non-hormonal. From a future perspective, identifying new hormonal combinations, suitable testicular targets, and emerging vas occlusion methods will produce novel molecules and products for male contraception.