未经证实:患有前列腺癌(PC)的男性心血管疾病(CVD)的发病率高于没有前列腺癌的男性。
未经评估:我们描述了男性PC患者心血管危险因素控制不良的发生率和相关性。
UNASSIGNED:我们对加拿大24个地点的2,811名连续男性(平均年龄68±8岁)进行了前瞻性表征,以色列,巴西,和澳大利亚。我们将总体风险因素控制不良定义为以下各项中的≥3:低密度脂蛋白胆固醇次优(如果Framingham风险评分[FRS]≥15,则>2mmol/L,如果FRS<15,则≥3.5mmol/L),目前的吸烟者,身体不活动(<600METmin/wk),次优血压(BP)(≥140/90mmHg,如果没有其他危险因素,如果已知CVD或FRS≥15,则收缩压≥120mmHg,如果糖尿病,则收缩压≥130/80mmHg),腰围:臀围比>0.9。
未经评估:在参与者中(9%患有转移性PC,23%患有预先存在的CVD),99%有≥1个未控制的心血管危险因素,51%的患者总体危险因素控制不佳。不服用他汀类药物(优势比[OR]:2.55;95%CI:2.00-3.26),身体虚弱(OR:2.37;95%CI:1.51-3.71),需要BP药物(OR:2.36;95%CI:1.84-3.03),和年龄(每10年增加的OR:1.34;95%CI:1.14-1.59)与调整教育后总体风险因素控制不佳相关,PC特性,雄激素剥夺疗法,抑郁症,和东部肿瘤协作组的功能状态。
未经评估:可改变的心血管危险因素控制不良在患有PC的男性中很常见,强调该人群在护理方面的巨大差距以及需要改进干预措施以优化心血管风险管理。
UNASSIGNED: Cardiovascular disease (CVD) incidence is higher in men with prostate cancer (PC) than without.
UNASSIGNED: We describe the rate and correlates of poor cardiovascular risk factor control among men with PC.
UNASSIGNED: We prospectively characterized 2,811 consecutive men (mean age 68 ± 8 years) with PC from 24 sites in Canada, Israel, Brazil, and Australia. We defined poor overall risk factor control as ≥3 of the following: suboptimal low-density lipoprotein cholesterol (>2 mmol/L if Framingham Risk Score [FRS] ≥15 and ≥3.5 mmol/L if FRS <15), current smoker, physical inactivity (<600 MET min/wk), suboptimal blood pressure (BP) (≥140/90 mm Hg if no other risk factors, systolic BP ≥120 mm Hg if known CVD or FRS ≥15, and ≥130/80 mm Hg if diabetic), and waist:hip ratio >0.9.
UNASSIGNED: Among participants (9% with metastatic PC and 23% with pre-existing CVD), 99% had ≥1 uncontrolled cardiovascular risk factor, and 51% had poor overall risk factor control. Not taking a statin (odds ratio [OR]: 2.55; 95% CI: 2.00-3.26), physical frailty (OR: 2.37; 95% CI: 1.51-3.71), need for BP drugs (OR: 2.36; 95% CI: 1.84-3.03), and age (OR per 10-year increase: 1.34; 95% CI: 1.14-1.59) were associated with poor overall risk factor control after adjustment for education, PC characteristics, androgen deprivation therapy, depression, and Eastern Cooperative Oncology Group functional status.
UNASSIGNED: Poor control of modifiable cardiovascular risk factors is common in men with PC, highlighting the large gap in care and the need for improved interventions to optimize cardiovascular risk management in this population.