未经证实:冠状病毒-2019(COVID-19)已知会影响心脏,并与促炎状态有关。迄今为止,大多数研究都集中在临床上患病的受试者上。这里,我们报告了在接受严重急性呼吸道综合征冠状病毒2(SARS-COV-2)检测后4~8周,无症状或轻度COVID-19感染的非卧床年轻成人的心脏和促炎生物标志物水平与未感染成人相比.
UNASSIGNED:在SARS-COV-2测试后,招募了131名无症状或轻度症状的受试者。50名受试者检测呈阴性,81名受试者检测呈阳性。收集血清样本用于测量C反应蛋白,铁蛋白,白细胞介素-6,NT-前-B型利钠肽,SARS-COV-2RT-PCR检测后28-55天和心肌肌钙蛋白。
未经评估:SARS-COV-2阳性受试者与阴性受试者的生物标志物水平有较高的趋势,但在SARS-COV-2状态方面,生物标志物水平或生物标志物升高的受试者比例差异无统计学意义.在有≥1合并症的个体中,与没有任何合并症的个体相比,CRP升高的几率更大(比值比[OR]=2.90);在SARS-COV-2阳性受试者中,这一效应大小增加了1.4倍(OR=4.03).同样,NT-pro-BNP与CVD相关,在COVID阳性个体中相关性最强(OR=16.9)。
未经评估:在一个相对年轻的,健康的成年人,在先前存在合并症的个体中,在轻度或无症状的COVID-19感染4-8周内,轻度COVID-19感染与心脏和促炎生物标志物的轻度升高相关,但不是在没有合并症的个人之间。对于一般的年轻人来说,我们没有发现COVID-19感染后4-8周心脏或促炎生物标志物升高的证据.临床观点:这是无症状或轻度COVID-19感染后不卧床受试者的心脏和促炎生物标志物的特征。年轻,在轻度COVID-19感染后4-8周,非卧床个体未出现心脏和促炎生物标志物升高.然而,COVID-19感染与某些合并症患者的生物标志物升高相关。临床研究编号:H-47423。
UNASSIGNED: Coronavirus-2019 (COVID-19) is known to affect the heart and is associated with a pro-inflammatory state. Most studies to date have focused on clinically sick subjects. Here, we report cardiac and proinflammatory biomarkers levels in ambulatory young adults with asymptomatic or mild COVID-19 infection compared to those without infection 4-8 weeks after severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) testing.
UNASSIGNED: 131 asymptomatic or mildly symptomatic subjects were enrolled following testing for SARS-COV-2. Fifty subjects tested negative, and 81 subjects tested positive. Serum samples were collected for measurement of C-reactive protein, ferritin, interleukin-6, NT-pro-B-type natriuretic peptide, and cardiac troponin 28-55 days after SARS-COV-2 RT-PCR testing.
UNASSIGNED: Biomarker levels trended higher in SARS-COV-2-positive vs negative subjects, but differences in biomarker levels or proportion of subjects with elevated biomarkers were not statistically significant with respect to SARS-COV-2 status. Among individuals with ≥ 1 comorbidity, odds of elevated CRP were greater compared to individuals without any comorbidities (odds ratio [OR] = 2.90); this effect size was increased 1.4-fold among SARS-COV-2-positive subjects (OR = 4.03). Similarly, NT-pro-BNP was associated with CVD, with the strongest association in COVID-positive individuals (OR = 16.9).
UNASSIGNED: In a relatively young, healthy adult population, mild COVID-19 infection was associated with mild elevations in cardiac and proinflammatory biomarkers within 4-8 weeks of mild or asymptomatic COVID-19 infection in individuals with preexisting comorbidities, but not among individuals without comorbidities. For the general population of young adults, we did not find evidence of elevation of cardiac or proinflammatory biomarkers 4-8 weeks after COVID-19 infection.Clinical Perspective: This is a characterization of cardiac and proinflammatory biomarkers in ambulatory subjects following asymptomatic or mild COVID-19 infection. Young, ambulatory individuals did not have cardiac and proinflammatory biomarker elevation 4-8 weeks after mild COVID-19 infection. However, COVID-19 infection was associated with biomarker elevations in select individuals with comorbidities.Clinical study number: H-47423.