目的:各种不健康的睡眠行为已被证明与泌尿系癌症的风险增加有关。然而,关于整体睡眠模式与泌尿系癌症之间的关联知之甚少。前瞻性调查健康睡眠模式与泌尿系癌症风险之间的关系,包括膀胱癌(BCa)和肾细胞癌(RCC)。
方法:在这项前瞻性队列研究中,从英国生物银行招募了377,144名基线无癌症的参与者。招募时通过问卷调查收集有关睡眠行为的数据。通过与国家癌症和死亡登记处的联系来确定泌尿系癌症的发生率。我们根据五个睡眠特征(睡眠持续时间,时间型,失眠,打鼾,和白天嗜睡)。Cox比例风险回归模型用于计算调整后的风险比和95%置信区间,以评估健康睡眠评分与泌尿系癌症风险之间的关系。
结果:在中位数≥9年的随访期间,我们发现了1986年的泌尿系癌症事件,其中BCa1272例,RCC706例。与睡眠模式较差(0-2分)的参与者相比,泌尿系癌症的多变量校正风险比和95%置信区间为0.85(0.75~0.96),BCa为0.80(0.68至0.93),碾压混凝土为0.91(0.74,1.12),分别,对于那些睡眠模式更健康的人(得分为4-5)。
结论:我们的研究结果表明,健康的睡眠模式与较低的泌尿系癌症风险相关。
OBJECTIVE: A variety of unhealthy sleep behaviors have been shown to be associated with an increased risk of urologic cancers. However, little is known about the association between the overall sleep patterns and urologic cancers. To prospectively investigate the associations between a healthy sleep pattern and the risks of urologic cancers, including bladder cancer (
BCa) and renal cell carcinoma (RCC).
METHODS: In this prospective cohort study, 377,144 participants free of cancer at baseline were recruited from the UK Biobank. Data on sleep behaviors were collected through questionnaires at recruitment. The incident urologic cancer cases were determined through linkage to national cancer and death registries. We established a healthy sleep score according to five sleep traits (sleep duration, chronotype, insomnia, snoring, and daytime sleepiness). Cox proportional hazard regression models were used to calculate the adjusted hazard ratios and 95% confidence intervals to assess the relationship between the healthy sleep score and the risk of urologic cancers.
RESULTS: During a median of ≥9 years of follow-up, we identified 1986 incident urologic cancer cases, including 1272
BCa cases and 706 RCC cases. Compared with the participants with a poor sleep pattern (score of 0-2), the multivariable-adjusted hazard ratio and 95% confidence interval were 0.85 (0.75 to 0.96) for urologic cancers, 0.80 (0.68 to 0.93) for
BCa, and 0.91 (0.74, 1.12) for RCC, respectively, for those with the healthier sleep pattern (score of 4-5).
CONCLUSIONS: Our results indicate that a healthy sleep pattern is associated with lower risks of urologic cancers.