随着不对称催化的迅速发展,对于具有不同手性元素的复杂和多样分子的对映选择性合成的需求正在增加。由于逆性异构的独特特征,阻转异构体的催化不对称合成引起了化学科学界的极大兴趣。特别是,引入额外的手性元素,如以碳为中心的手性,杂原子手性,平面手性,和螺旋手性,进入阻转异构体提供了将新的性质纳入轴向手性化合物的机会,从而扩大阻转异构体的潜在应用。因此,重要的是进行催化不对称转化以合成具有多个手性元素的阻转异构体。尽管这种转变面临挑战,近年来,化学家在不对称有机催化或金属催化下设计了强大的策略,合成具有多种手性元素的富含对映异构体的阻转异构体。因此,催化不对称合成具有多手性元素的阻转异构体已成为新兴领域。这篇综述总结了这一领域的快速进展,并指出了挑战,从而将这一领域推向新的视野。
With the rapid development of asymmetric catalysis, the demand for the enantioselective synthesis of complex and diverse molecules with different chiral elements is increasing. Owing to the unique features of atropisomerism, the catalytic asymmetric synthesis of atropisomers has attracted a considerable interest from the chemical science community. In particular, introducing additional chiral elements, such as carbon centered chirality, heteroatomic chirality, planar chirality, and helical chirality, into atropisomers provides an opportunity to incorporate new properties into axially chiral compounds, thus expanding the potential applications of atropisomers. Thus, it is important to perform catalytic asymmetric transformations to synthesize atropisomers bearing multiple chiral elements. In spite of challenges in such transformations, in recent years, chemists have devised powerful strategies under asymmetric organocatalysis or metal catalysis, synthesizing a wide range of enantioenriched atropisomers bearing multiple chiral elements. Therefore, the catalytic asymmetric synthesis of atropisomers bearing multiple chiral elements has become an emerging field. This review summarizes the rapid progress in this field and indicates challenges, thereby promoting this field to a new horizon.