目的:目前对和肽素之间的关系了解有限,肾上腺髓质素前体(MRproADM)和心房利钠肽(MRproANP)N末端的中间区域片段,和动脉疾病。脚趾肱指数(TBI)和主动脉脉搏波速度(aPWV)是检测动脉疾病的建立参数。这项研究评估了和肽素,MRproADM,在无心血管疾病(CVD)病史的2型糖尿病患者中,MRproANP与TBI和aPWV相关.
方法:在CARDIPP研究中,对基线时无CVD病史的519例年龄在55-65岁的2型糖尿病患者进行了横断面分析,有关于copeptin的完整数据,MRproADM,MRproANP,TBI,并进行了aPWV。线性回归分析用于研究传统CVD危险因素之间的关联。copeptin,MRproADM,MRproANP,TBI,和aPWV。
结果:和肽素与TBI相关(β-0.0020,CI-0.0035-(-0.0005),p=0.010)和aPWV(β0.023,CI0.002-0.044,p=0.035)。这些关联与年龄无关,性别,糖尿病持续时间,平均24小时动态收缩压,糖化血红蛋白A1c,总胆固醇,估计肾小球滤过率,身体质量指数,积极吸烟。
结论:血浆和肽素可能是识别动脉疾病高危个体的有用替代指标。
背景:ClinicalTrials.gov标识符NCT010497377。
OBJECTIVE: There is currently limited understanding of the relationship between copeptin, the midregional portion of proadrenomedullin (MRproADM) and the midregional fragment of the N-terminal of proatrial natriuretic peptide (MRproANP), and arterial disorders. Toe brachial index (TBI) and aortic pulse wave velocity (aPWV) are established parameters for detecting arterial disorders. This study evaluated whether copeptin, MRproADM, and MRproANP were associated with TBI and aPWV in patients with type 2 diabetes with no history of cardiovascular disease (CVD).
METHODS: In the CARDIPP study, a cross-sectional analysis of 519 patients with type 2 diabetes aged 55-65 years with no history of CVD at baseline, had complete data on copeptin, MRproADM, MRproANP, TBI, and aPWV was performed. Linear regression analysis was used to investigate the associations between conventional CVD risk factors, copeptin, MRproADM, MRproANP, TBI, and aPWV.
RESULTS: Copeptin was associated with TBI (β-0.0020, CI-0.0035- (-0.0005), p = 0.010) and aPWV (β 0.023, CI 0.002-0.044, p = 0.035). These associations were independent of age, sex, diabetes duration, mean 24-hour ambulatory systolic blood pressure, glycated hemoglobin A1c, total cholesterol, estimated glomerular filtration rate, body mass index, and active smoking.
CONCLUSIONS: Plasma copeptin may be a helpful surrogate for identifying individuals at higher risk for arterial disorders.
BACKGROUND: ClinicalTrials.gov identifier NCT010497377.