■Erionite是在某些地理区域的土壤中发现的天然存在的纤维矿物。以其在土耳其卡帕多西亚地区引起间皮瘤的效力而闻名,由于它存在于从墨西哥延伸到蒙大拿州的一块岩石中,因此在美国引起了人们的兴趣。对毛沸石的毒理学研究很少,但都显示它有异常高的慢性毒性。尽管与石棉纤维相比具有很高的效力,钙沸石没有职业或环境暴露限制。本文以对各种形式的石棉(温石棉,amosite,直闪石,和青石棉),并预测北美钙沸石纤维的效力。
■基于Korchevskiy等人的纤维效能模型。(2019)和现有的关于钙沸石的公布信息,在美国西部地区,我们确定了平均间皮瘤效应因子(每单位累积暴露量(f/cc-年)所占间皮瘤死亡率的比例).
■模型预测的效价因子范围为0.19至11.25(平均〜3.5),取决于地区。供参考,青石棉(最有效的商业形式的石棉)被指定为效力系数~0.5。
■该模型预测土耳其钙石(4.53)的间皮瘤效力与北美钙石的效力范围相同。尽管它可能因地区而异,基于此模型的平均间皮瘤效力的合理比例为3,000:500:100:1,比较北美的赤铁矿,青石棉,amosite,和温石棉(从最有效到最无效)。
UNASSIGNED: Erionite is a naturally occurring fibrous mineral found in soils in some geographical regions. Known for its potency for causing mesothelioma in the Cappadocia region of Turkey, the erionite fiber has attracted interest in the United States due to its presence in a band of rock that extends from Mexico to Montana. There are few toxicology studies of erionite, but all show it to have unusually high chronic toxicity. Despite its high potency compared to asbestos fibers, erionite has no occupational or environmental exposure limits. This paper takes what has been learned about the chemical and physical characteristics of the various forms of asbestos (chrysotile, amosite, anthophyllite, and crocidolite) and predicts the potency of North American erionite fibers.
UNASSIGNED: Based on the fiber potency model in Korchevskiy et al. (2019) and the available published information on erionite, the estimated mesothelioma potency factors (the proportion of mesothelioma mortality per unit cumulative exposure (f/cc-year)) for erionites in the western United States were determined.
UNASSIGNED: The model predicted potency factors ranged from 0.19 to 11.25 (average ∼3.5), depending on the region. For reference, crocidolite (the most potent commercial form of asbestos) is assigned a potency factor ∼0.5.
UNASSIGNED: The model predicted mesothelioma potency of Turkish erionite (4.53) falls in this same range of potencies as erionite found in North America. Although it can vary by region, a reasonable ratio of average mesothelioma potency based on this model is 3,000:500:100:1 comparing North American erionite, crocidolite, amosite, and chrysotile (from most potent to least potent).