BACKGROUND: The timely allocation of appointments for new patients is a daily challenge in rheumatological practice, which can be supported by digital solutions. The question is to find the simplest and most effective possible method for prioritization when allocating appointments.
METHODS: Using a registration form for new patients, standardized symptoms and laboratory results were collated. After reviewing this information by a medical specialist the allocation of appointments was carried out in three categories: a) < 6 weeks, b) 6 weeks up to 3 months and c) > 3 months. The waiting time between the time of registration and the presentation appointment was calculated and compared between patients with and without a diagnosis of an inflammatory rheumatic disease (IRD). In addition a decision tree (DT), a method taken from the field of supervised learning within artificial intelligence (AI), was established and the resulting classification was compared with respect to the accuracy and calculated saving in waiting time.
RESULTS: In this study 800 appointments between 2020 and 2023 (including 555 women, 69.4%, median age 53 years, interquartile range, IQR 39-63 years) were analyzed. An IRD could be confirmed in 409 (51.1%) cases with a waiting time of 58 vs. 93 days for non-IRD cases (-38%, p < 0.01). An AI-based stratification resulted in an accuracy of 67% for IRD and a predicted saving of 19% waiting time. The accuracy increased up to 78% with a time saving for IRD cases of up to 31%, when all basic laboratory results were known. Simplified algorithms, e.g., stratification by the use of laboratory findings alone, resulted in a lower accuracy and time savings.
CONCLUSIONS: Manual allocation of appointments by a medical specialist is effective and significantly reduces the waiting times for patients with IRD. An automated categorization can lead to a reduction in waiting times for appointments when taking complete laboratory results and a lower sensitivity into consideration.
UNASSIGNED: HINTERGRUND: Die zeitnahe Terminvergabe für Neuvorstellungen ist eine tägliche Herausforderung in der rheumatologischen Praxis, die von digitalen Lösungen unterstützt werden kann. Es stellt sich die Frage nach einer möglichst einfachen und effektiven Methode der Terminpriorisierung.
METHODS: Mithilfe eines Anmeldeformulars für Neuvorstellungen wurden standardisiert Symptome und Laborbefunde erfasst. Die Terminvergabe erfolgte nach fachärztlicher Sichtung dieser Informationen in 3 Kategorien: (a) < 6 Wochen, (b) 6 Wochen bis 3 Monate und (c) > 3 Monate. Die Wartezeiten zwischen dem Zeitpunkt der Anmeldung und dem Vorstellungstermin wurden berechnet und verglichen zwischen Patienten mit und ohne Diagnose einer entzündlich-rheumatischen Erkrankung (ERE). Zusätzlich wurde ein Entscheidungsbaum, eine Methode aus dem Bereich des überwachten Lernens innerhalb der künstlichen Intelligenz (KI), erstellt und die resultierende Klassifikation bezüglich Trefferrate und berechneter Wartezeitersparnis verglichen.
UNASSIGNED: Insgesamt wurden 800 Fälle (darunter 555 Frauen [69,4 %], medianes Alter 53 Jahre [IQA 39–63]) zwischen 2020 und 2023 ausgewertet. Eine ERE konnte in 409 (51,1 %) Fällen bestätigt werden mit einer Wartezeit von 58 vs. 93 Tagen bei Non-ERE-Fällen (−38 %, p < 0,01). Eine KI-Stratifizierung ergab eine Trefferrate von 67 % bezüglich einer ERE und eine prognostizierte Einsparung von 19 % Wartezeit. Die Trefferrate stieg hierbei auf 78 % mit einer Zeitersparnis für ERE-Fälle um bis zu 31 %, wenn grundlegende Laborergebnisse bekannt waren. Andererseits ergaben vereinfachte Algorithmen z. B. durch eine reine Laborwert-basierte Stratifizierung eine niedrigere Trefferrate und Zeitersparnis.
UNASSIGNED: Die fachärztliche Terminzuweisung ist effektiv und verkürzt die Terminwartezeit für Patienten mit ERE signifikant. Eine automatisierte Kategorisierung kann unter Berücksichtigung vollständiger Laborwerte mit reduzierter Sensitivität zu einer Verkürzung der Terminwartezeit führen.

Introduction: This study explores using Neural Ordinary Differential Equations (NODEs) to analyze hormone dynamics in the hypothalamicpituitary-adrenal (HPA) axis during Trier Social Stress Tests (TSST) to classify patients with Major Depressive Disorder (MDD). Methods: Data from TSST were used, measuring plasma ACTH and cortisol concentrations. NODE models replicated hormone changes without prior knowledge of the stressor. The derived vector fields from NODEs were input into a Convolutional Neural Network (CNN) for patient classification, validated through cross-validation (CV) procedures. Results: NODE models effectively captured system dynamics, embedding stress effects in the vector fields. The classification procedure yielded promising results, with the 1x1 CV achieving an AUROC score that correctly identified 83% of Atypical MDD patients and 53% of healthy controls. The 2x2 CV produced similar outcomes, supporting model robustness. Discussion: Our results demonstrate the potential of combining NODEs and CNNs to classify patients based on disease state, providing a preliminary step towards further research using the HPA axis stress response as an objective biomarker for MDD.

UNASSIGNED: The incidence rate of lung cancer, which also has the highest mortality rates for both men and women worldwide, is increasing globally. Due to advancements in imaging technology and the growing inclination of individuals to undergo screening, the detection rate of ground-glass nodules (GGNs) has surged rapidly. Currently, artificial intelligence (AI) methods for data analysis and interpretation, image processing, illness diagnosis, and lesion prediction offer a novel perspective on the diagnosis of GGNs. This article aimed to examine how to detect malignant lesions as early as possible and improve clinical diagnostic and treatment decisions by identifying benign and malignant lesions using imaging data. It also aimed to describe the use of computed tomography (CT)-guided biopsies and highlight developments in AI techniques in this area.
UNASSIGNED: We used PubMed, Elsevier ScienceDirect, Springer Database, and Google Scholar to search for information relevant to the article\'s topic. We gathered, examined, and interpreted relevant imaging resources from the Second Affiliated Hospital of Nanchang University\'s Imaging Center. Additionally, we used Adobe Illustrator 2020 to process all the figures.
UNASSIGNED: We examined the common signs of GGNs, elucidated the relationship between these signs and the identification of benign and malignant lesions, and then described the application of AI in image segmentation, automatic classification, and the invasiveness prediction of GGNs over the last three years, including its limitations and outlook. We also discussed the necessity of conducting biopsies of persistent pure GGNs.
UNASSIGNED: A variety of imaging features can be combined to improve the diagnosis of benign and malignant GGNs. The use of CT-guided puncture biopsy to clarify the nature of lesions should be considered with caution. The development of new AI tools brings new possibilities and hope to improving the ability of imaging physicians to analyze GGN images and achieving accurate diagnosis.

UNASSIGNED: Axial spondyloarthritis (axSpA) is frequently diagnosed late, particularly in human leukocyte antigen (HLA)-B27-negative patients, resulting in a missed opportunity for optimal treatment. This study aimed to develop an artificial intelligence (AI) tool, termed NegSpA-AI, using sacroiliac joint (SIJ) magnetic resonance imaging (MRI) and clinical SpA features to improve the diagnosis of axSpA in HLA-B27-negative patients.
UNASSIGNED: We retrospectively included 454 HLA-B27-negative patients with rheumatologist-diagnosed axSpA or other diseases (non-axSpA) from the Third Affiliated Hospital of Southern Medical University and Nanhai Hospital between January 2010 and August 2021. They were divided into a training set (n=328) for 5-fold cross-validation, an internal test set (n=72), and an independent external test set (n=54). To construct a prospective test set, we further enrolled 87 patients between September 2021 and August 2023 from the Third Affiliated Hospital of Southern Medical University. MRI techniques employed included T1-weighted (T1W), T2-weighted (T2W), and fat-suppressed (FS) sequences. We developed NegSpA-AI using a deep learning (DL) network to differentiate between axSpA and non-axSpA at admission. Furthermore, we conducted a reader study involving 4 radiologists and 2 rheumatologists to evaluate and compare the performance of independent and AI-assisted clinicians.
UNASSIGNED: NegSpA-AI demonstrated superior performance compared to the independent junior rheumatologist (≤5 years of experience), achieving areas under the curve (AUCs) of 0.878 [95% confidence interval (CI): 0.786-0.971], 0.870 (95% CI: 0.771-0.970), and 0.815 (95% CI: 0.714-0.915) on the internal, external, and prospective test sets, respectively. The assistance of NegSpA-AI promoted discriminating accuracy, sensitivity, and specificity of independent junior radiologists by 7.4-11.5%, 1.0-13.3%, and 7.4-20.6% across the 3 test sets (all P<0.05). On the prospective test set, AI assistance also improved the diagnostic accuracy, sensitivity, and specificity of independent junior rheumatologists by 7.7%, 7.7%, and 6.9%, respectively (all P<0.01).
UNASSIGNED: The proposed NegSpA-AI effectively improves radiologists\' interpretations of SIJ MRI and rheumatologists\' diagnoses of HLA-B27-negative axSpA.

UNASSIGNED: The integration of artificial intelligence (AI) into medicine is growing, with some experts predicting its standalone use soon. However, skepticism remains due to limited positive outcomes from independent validations. This research evaluates AI software\'s effectiveness in analyzing chest X-rays (CXR) to identify lung nodules, a possible lung cancer indicator.
UNASSIGNED: This retrospective study analyzed 7,670,212 record pairs from radiological exams conducted between 2020 and 2022 during the Moscow Computer Vision Experiment, focusing on CXR and computed tomography (CT) scans. All images were acquired during clinical routine. The final dataset comprised 100 CXR images (50 with lung nodules, 50 without), selected consecutively and based on inclusion and exclusion criteria, to evaluate the performance of all five AI-based solutions, participating in the Moscow Computer Vision Experiment and analyzing CXR. The evaluation was performed in 3 stages. In the first stage, the probability of a nodule in the lung obtained from AI services was compared with the Ground Truth (1-there is a nodule, 0-there is no nodule). In the second stage, 3 radiologists evaluated the segmentation of nodules performed by the AI services (1-nodule correctly segmented, 0-nodule incorrectly segmented or not segmented at all). In the third stage, the same radiologists additionally evaluated the classification of the nodules (1-nodule correctly segmented and classified, 0-all other cases). The results obtained in stages 2 and 3 were compared with Ground Truth, which was common to all three stages. For each stage, diagnostic accuracy metrics were calculated for each AI service.
UNASSIGNED: Three software solutions (Celsus, Lunit INSIGHT CXR, and qXR) demonstrated diagnostic metrics that matched or surpassed the vendor specifications, and achieved the highest area under the receiver operating characteristic curve (AUC) of 0.956 [95% confidence interval (CI): 0.918 to 0.994]. However, when evaluated by three radiologists for accurate nodule segmentation and classification, all solutions performed below the vendor-declared metrics, with the highest AUC reaching 0.812 (95% CI: 0.744 to 0.879). Meanwhile, all AI services demonstrated 100% specificity at stages 2 and 3 of the study.
UNASSIGNED: To ensure the reliability and applicability of AI-based software, it is crucial to validate performance metrics using high-quality datasets and engage radiologists in the evaluation process. Developers are recommended to improve the accuracy of the underlying models before allowing the standalone use of the software for lung nodule detection. The dataset created during the study may be accessed at https://mosmed.ai/datasets/mosmeddatargogksnalichiemiotsutstviemlegochnihuzlovtipvii/.

UNASSIGNED: The coronary artery calcium score (CACS) has been shown to be an independent predictor of cardiovascular events. The traditional coronary artery calcium scoring algorithm has been optimized for electrocardiogram (ECG)-gated images, which are acquired with specific settings and timing. Therefore, if the artificial intelligence-based coronary artery calcium score (AI-CACS) could be calculated from a chest low-dose computed tomography (LDCT) examination, it could be valuable in assessing the risk of coronary artery disease (CAD) in advance, and it could potentially reduce the occurrence of cardiovascular events in patients. This study aimed to assess the performance of an AI-CACS algorithm in non-gated chest scans with three different slice thicknesses (1, 3, and 5 mm).
UNASSIGNED: A total of 135 patients who underwent both LDCT of the chest and ECG-gated non-contrast enhanced cardiac CT were prospectively included in this study. The Agatston scores were automatically derived from chest CT images reconstructed at slice thicknesses of 1, 3, and 5 mm using the AI-CACS software. These scores were then compared to those obtained from the ECG-gated cardiac CT data using a conventional semi-automatic method that served as the reference. The correlations between the AI-CACS and electrocardiogram-gated coronary artery calcium score (ECG-CACS) were analyzed, and Bland-Altman plots were used to assess agreement. Risk stratification was based on the calculated CACS, and the concordance rate was determined.
UNASSIGNED: A total of 112 patients were included in the final analysis. The correlations between the AI-CACS at three different thicknesses (1, 3, and 5 mm) and the ECG-CACS were 0.973, 0.941, and 0.834 (all P<0.01), respectively. The Bland-Altman plots showed mean differences in the AI-CACS for the three thicknesses of -6.5, 15.4, and 53.1, respectively. The risk category agreement for the three AI-CACS groups was 0.868, 0.772, and 0.412 (all P<0.01), respectively. While the concordance rates were 91%, 84.8%, and 62.5%, respectively.
UNASSIGNED: The AI-based algorithm successfully calculated the CACS from LDCT scans of the chest, demonstrating its utility in risk categorization. Furthermore, the CACS derived from images with a slice thickness of 1 mm was more accurate than those obtained from images with slice thicknesses of 3 and 5 mm.

Cardiac xenotransplantation (cXT) has emerged as a solution to heart donor scarcity, prompting an exploration of its scientific, ethical, and regulatory facets. The review begins with genetic modifications enhancing pig hearts for human transplantation, navigating through immunological challenges, rejection mechanisms, and immune responses. Key areas include preclinical milestones, complement cascade roles, and genetic engineering to address hyperacute rejection. Physiological counterbalance systems, like human thrombomodulin and endothelial protein C receptor upregulation in porcine xenografts, highlight efforts for graft survival enhancement. Evaluating pig and baboon donors and challenges with non-human primates illuminates complexities in donor species selection. Ethical considerations, encompassing animal rights, welfare, and zoonotic disease risks, are critically examined in the cXT context. The review delves into immune control mechanisms with aggressive immunosuppression and clustered regularly interspaced palindromic repeats associated protein 9 (CRISPR/Cas9) technology, elucidating hyperacute rejection, complement activation, and antibody-mediated rejection intricacies. CRISPR/Cas9\'s role in creating pig endothelial cells expressing human inhibitor molecules is explored for rejection mitigation. Ethical and regulatory aspects emphasize the role of committees and international guidelines. A forward-looking perspective envisions precision medical genetics, artificial intelligence, and individualized heart cultivation within pigs as transformative elements in cXT\'s future is also explored. This comprehensive analysis offers insights for researchers, clinicians, and policymakers, addressing the current state, and future prospects of cXT.

OBJECTIVE: This review summarizes the current and potential uses of artificial intelligence (AI) in the current state of clinical microbiology with a focus on replacement of labor-intensive tasks.
METHODS: A search was conducted on PubMed using the key terms clinical microbiology and artificial intelligence. Studies were reviewed for relevance to clinical microbiology, current diagnostic techniques, and potential advantages of AI in routine microbiology workflows.
RESULTS: Numerous studies highlight potential labor, as well as diagnostic accuracy, benefits to the implementation of AI for slide-based and macroscopic digital image analyses. These range from Gram stain interpretation to categorization and quantitation of culture growth.
CONCLUSIONS: Artificial intelligence applications in clinical microbiology significantly enhance diagnostic accuracy and efficiency, offering promising solutions to labor-intensive tasks and staffing shortages. More research efforts and US Food and Drug Administration clearance are still required to fully incorporate these AI applications into routine clinical laboratory practices.

OBJECTIVE: To explore the integration of generative AI, specifically large language models (LLMs), in ophthalmology education and practice, addressing their applications, benefits, challenges, and future directions.
METHODS: A literature review and analysis of current AI applications and educational programs in ophthalmology.
METHODS: Analysis of published studies, reviews, articles, websites, and institutional reports on AI use in ophthalmology. Examination of educational programs incorporating AI, including curriculum frameworks, training methodologies, and evaluations of AI performance on medical examinations and clinical case studies.
RESULTS: Generative AI, particularly LLMs, shows potential to improve diagnostic accuracy and patient care in ophthalmology. Applications include aiding in patient, physician, and medical students\' education. However, challenges such as AI hallucinations, biases, lack of interpretability, and outdated training data limit clinical deployment. Studies revealed varying levels of accuracy of LLMs on ophthalmology board exam questions, underscoring the need for more reliable AI integration. Several educational programs nationwide provide AI and data science training relevant to clinical medicine and ophthalmology.
CONCLUSIONS: Generative AI and LLMs offer promising advancements in ophthalmology education and practice. Addressing challenges through comprehensive curricula that include fundamental AI principles, ethical guidelines, and updated, unbiased training data is crucial. Future directions include developing clinically relevant evaluation metrics, implementing hybrid models with human oversight, leveraging image-rich data, and benchmarking AI performance against ophthalmologists. Robust policies on data privacy, security, and transparency are essential for fostering a safe and ethical environment for AI applications in ophthalmology.

Early identification of pancreatitis remains a significant clinical diagnostic challenge that impacts patient outcomes. The evolution of quantitative imaging followed by deep learning models has shown great promise in the non-invasive diagnosis of pancreatitis and its complications. We provide an overview of advancements in diagnostic imaging and quantitative imaging methods along with the evolution of artificial intelligence (AI). In this article, we review the current and future states of methodology and limitations of AI in improving clinical support in the context of early detection and management of pancreatitis.