这项研究旨在评估单独或与臭氧气体相关的网状透明质酸在治疗犬髋关节发育不良引起的骨关节炎中的作用。将14只客户拥有的狗随机分为两组:第1组-单次关节内注射透明质酸;第2组-单次关节内浸润注射与臭氧气体相关的透明质酸。每个髋关节平均接受0.75mL网状透明质酸超声引导。通过吹入将45μg/mL剂量的臭氧气体掺入透明质酸中。狗被评估的身体状况评分,髋关节的骨科检查和影像学评分,髋关节测角测量,视觉步态评分,和动力学分析。评估是在治疗前立即进行的(M0),在第30天(M1),60(M2),治疗后90(M3)。在所有评估时刻,每组的体重和身体状况评分(5分量表)均无显着差异。各组间髋关节矫形检查评分均有统计学差异(M0>M3),但组间未观察到差异.两组之间的影像学评分无统计学差异,但观察到治疗前(G1>G2)和治疗后90(G1>G2)的组间差异。髋关节屈曲和伸展的测角测量显示,两组之间或两组之间没有显着差异。关于跛行评分,组间无统计学差异。第1组M0>M2和M0>M3,第2组M0>M1,M0>M2和M0>M3之间的跛行得分存在显着差异。第1组中M3和M0之间PVF和VI的平均变化百分比几乎为零,第2组中为阳性,分别为31.1±29.4和10.6±25.4。总之,单独或与臭氧气体相关的关节内粘度补充可以改善跛行评分和骨科检查评分。在第2组中,臭氧气体的关联在动力学分析中具有更好的结果。
This study aimed to evaluate reticulated hyaluronic acid alone or associated with ozone gas in the treatment of osteoarthritis due to hip dysplasia in dogs. Fourteen client-owned dogs were randomly assigned into two groups: Group 1-single intra-articular injection of hyaluronic acid; Group 2-single intra-articular infiltration injection of hyaluronic acid associated with ozone gas. Each hip joint received an average of 0.75 mL of reticulated hyaluronic acid ultrasound-guided. Ozone gas at a dose of 45 μg/mL was incorporated into hyaluronic acid by insufflation. Dogs were evaluated for body condition scoring, orthopedic examination and radiographic scores of the hip joints, goniometric measurements of the hip joints, visual gait score, and kinetic analysis. The evaluations were conducted immediately before treatments (M0), and at days 30 (M1), 60 (M2), and 90 (M3) after treatments. There were no significant differences in body mass and body condition scoring (5-point scale) in each group in all evaluation moments. The scores of orthopedic examination of the hip joints showed statistical differences in each group between moments (M0 > M3), but differences were not observed between groups. No statistical differences were found for radiographic scores in each group between moments, but differences were observed between groups immediately prior to treatments (G1 > G2) and 90 (G1 > G2) after treatments. Goniometric measurements of hip flexion and extension showed no significant differences in each group between moments or between groups. No statistical differences between groups were found concerning the lameness score. There were significant differences for lameness score among moments in Group 1, being M0 > M2 and M0 > M3, and Group 2 in which M0 > M1, M0 > M2, and M0 > M3. The mean percentage of change of PVF and VI between M3 and M0 in Group 1 was almost null and in Group 2 was positive, being 31.1 ± 29.4 and 10.6 ± 25.4, respectively. In conclusion, the intra-articular viscosupplementation alone or associated with ozone gas allowed improvement of lameness scores and orthopedic examination score. In Group 2 the association of ozone gas had better results on kinetic analysis.