Arteriovenous fistula

动静脉瘘
  • 文章类型: Journal Article
    可靠的血管通路的构建和利用对于血液透析至关重要。尽管它很重要,血管通路并发症很常见,显着影响患者的发病率和死亡率。本报告提出了一种使用“线吻技术”和“外化和拉穿技术”治疗血液透析血管通路慢性完全闭塞(CTO)的新方法。一名82岁接受血液透析的妇女头静脉有血栓阻塞,传统方法无法解决的问题。接吻技术允许CTO病变内顺行和逆行的线相遇,稳定线和促进气球通过。外化和牵拉技术进一步使球囊能够穿过刚性CTO病变,成功完成经皮腔内血管成形术(PTA)。术后超声检查显示流量和阻力指数显着改善。这些技术,常用于冠状动脉和股动脉,以前没有关于透析血管通路的报道。该案例突出了克服CTO病变穿越技术困难的新颖有效的解决方案,可能改善血液透析患者血管通路的结局.
    The construction and utilization of dependable vascular access are essential for hemodialysis. Despite its importance, complications with vascular access are common, significantly impacting patient morbidity and mortality. This report presents a novel approach to treating chronic total occlusion (CTO) in hemodialysis vascular access using the \"wire kissing technique\" an \"externalization and pull-through technique.\" An 82-year-old woman on hemodialysis had a thrombotic obstruction in her cephalic vein, which conventional methods failed to address. The wire kissing technique allowed the meeting of antegrade and retrograde wires within the CTO lesion, stabilizing the wire and facilitating balloon passage. The externalization and pull-through technique further enabled the balloon to cross the rigid CTO lesion, successfully completing percutaneous transluminal angioplasty (PTA). Post-procedure ultrasonography showed significant improvements in flow volume and resistance index. These techniques, commonly used in coronary and femoral arteries, have not been previously reported for dialysis vascular access. This case highlights a novel and effective solution for overcoming technical difficulties in crossing CTO lesions, potentially improving outcomes in vascular access for hemodialysis patients.
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  • 文章类型: Journal Article
    球囊辅助成熟(BAM)是一种成熟的技术,用于成熟不足的动静脉瘘(AVF)。这项研究的目的是评估使用大直径血管成形术球囊的初始BAM的结果。
    回顾了2018年至2021年在单一学术机构接受BAM的患者图表。AVF成熟率是主要结果。次要结果包括手术并发症,再干预率,术后静脉直径,和无导管血液透析(HD)的时间。将接受直径为7mm球囊的初始BAM(I组)的患者的结果与具有<7mm球囊的初始BAM(II组)的患者的结果进行比较。
    与II组(n=90)相比,I组(n=149)是一个明显年轻的队列,男性更多。手术细节和并发症发生率无显著差异。中位静脉直径较大(5.9mm,IQR:5-6.4)在第一组中与第二组相比(5.1毫米,IQR:4.2-5.9;p=0.03)在术后双工超声检查中。第二组中静脉狭窄的发生率也较高。第一组的总体成熟率较高(97%vs88%,p=0.003),II组患者中更大比例的患者需要一个以上的BAM才能达到成熟(33%vs16%,p=0.002)。第一次BAM后无导管HD的中位时间在I组为29天(IQR:19-47),在II组为42天(IQR:24-75)(p=0.002)。第一次BAM后60天,无导管HD的发生率在I组为83%,在II组为67%(p=0.001).
    我们的研究表明,在初始BAM过程中利用大型血管成形术球囊的能力与较高的AVF成熟率相关,且较少的再干预和较短的无导管透析时间。可以容忍该过程的AVF通常具有更有利的基线特征。
    UNASSIGNED: Balloon-assisted maturation (BAM) is a well-established technique for maturation of inadequate arteriovenous fistulas (AVF). The objective of this study was to evaluate outcomes of initial BAM using large-diameter angioplasty balloons.
    UNASSIGNED: Charts of patients who underwent BAM between 2018 and 2021 at a single academic institution were reviewed. AVF maturation rate was the primary outcome. Secondary outcomes included procedural complications, re-intervention rates, post-procedure vein diameter, and time to catheter-free hemodialysis (HD). Outcomes of patients that underwent initial BAM with ⩾7 mm diameter balloons (Group I) were compared to those of patients that had initial BAM with <7 mm balloons (Group II).
    UNASSIGNED: Group I (n = 149) was a significantly younger cohort and had more men compared to Group II (n = 90). There were no significant differences associated with procedural details and complication rates. Median vein diameter was larger (5.9 mm, IQR: 5-6.4) in Group I compared to Group II (5.1 mm, IQR: 4.2-5.9; p = 0.03) on post-procedure Duplex ultrasound. There was also a higher incidence of vein stenosis in Group II. The overall maturation rate was higher in Group I (97% vs 88%, p = 0.003), and a larger proportion of patients in Group II required more than one BAM to achieve maturation (33% vs 16%, p = 0.002). The median time to catheter-free HD after first BAM was 29 days (IQR: 19-47) in Group I and 42 days (IQR: 24-75) in Group II (p = 0.002). At 60 days after first BAM, the incidence of catheter-free HD was 83% in Group I versus 67% in Group II (p = 0.001).
    UNASSIGNED: Our study demonstrates that the ability to utilize large angioplasty balloons during initial BAM is associated with higher rates of AVF maturation with fewer re-interventions and shorter time to catheter-free dialysis. AVFs that can tolerate this procedure often have more favorable baseline characteristics.
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  • 文章类型: Journal Article
    超声检查更常用于动静脉瘘(AVF)狭窄患者。这项研究的目的是使用超声参数来预测接受超声引导的经皮腔内血管成形术(PTA)治疗的静脉瓣膜相关狭窄(VVRS)的血液透析患者的主要通畅性。
    共纳入在2017年1月至2021年12月期间接受PTA的229例VVRS患者。回顾性收集临床特征。在PTA之前和之后测量超声参数。进行单变量和多变量Cox分析以确定与原发性通畅率相关的独立因素。
    与PTA之前相比,PTA之后所有测得的超声图像参数都得到了改善。在PTA之前,VVRS的直径>1.0mm,年龄≤57岁,体重指数(BMI)>21.57kg/m2与更好的结局相关。而桡动脉的直径,靠近吻合口的近端桡动脉,肱动脉,肱动脉的流量,VVRS的长度和峰值速度(PV),VVRS后的直径和PV与主要通畅率无关。PTA之后,只有VVRS直径>4.0mm的患者有良好的预后.此外,PTA后VVRS直径增加>2.4mm的患者有更好的结局趋势.
    PTA前后VVRS的直径可以作为预测VVRS的AVF患者的初次通畅率和二次通畅率的指标。VVRS的直径增益也可以是潜在的标记。
    结论:使用简单的超声参数标记,我们可以快速识别再狭窄风险较高的患者.在早期再狭窄的情况下,应更密切地随访这些患者。它也有利于预防血栓形成。这些措施有助于为长期透析保留更有价值的血管。此外,医生应该更加注意这些危险患者的透析相关并发症,如血液透析相关的低血压。
    UNASSIGNED: Ultrasonography is more frequently used in patients with arteriovenous fistula (AVF) stenosis. The aim of this study is to use sonographic parameters for predicting primary patency in hemodialysis patients with venous valve-related stenosis (VVRS) who are treated by ultrasound-guided percutaneous transluminal angioplasty (PTA).
    UNASSIGNED: A total of 229 VVRS patients who underwent PTA between January 2017 and December 2021 were enrolled. Clinical characteristics were retrospectively collected. Sonographic parameters were measured both before and after PTA. Univariate and multivariate Cox analyses were performed to identify independent factors associated with primary patency rate.
    UNASSIGNED: All measured sonographic parameters improved after PTA compared to before PTA. Before PTA, the diameter of VVRS > 1.0 mm, age ≤ 57 years, and body mass index (BMI) > 21.57 kg/m2 were associated with better outcomes. While the diameter of radial artery, proximal radial artery close to the anastomosis, brachial artery, the flow volume of brachial artery, the length and peak velocity (PV) of the VVRS, and the diameter and PV after the VVRS had no association with the primary patency rate. After PTA, only patients with a diameter of VVRS > 4.0 mm had favorable outcome. In addition, patients with a gain of diameter of VVRS > 2.4 mm after PTA had a trend of better outcomes.
    UNASSIGNED: The diameter of VVRS before and after PTA could be served as markers to predict primary patency rate and second patency rate in AVF patients with VVRS. The gain of diameter of VVRS could also be a potential marker.
    CONCLUSIONS: Using simple markers of sonographic parameters, we could quickly identify patients with a higher risk of restenosis. These patients should be followed more closely in case of restenosis at early. It is also beneficial to the prevention of thrombosis. These measures help to preserve more valuable vascular for a long-term dialysis. Additionally, the physician should pay more attention on the dialysis-related complications in these risky patients, such as hemodialysis-related hypotension.
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  • 文章类型: Journal Article
    目的:颅颈交界区(CCJ)动静脉瘘(AVF)很少见。CCJAVF的临床表现和治疗策略的变异性源于其血管结构的差异。我们的研究旨在根据CCJAVF的血管结构对其进行分类,并探索不同CCJAVF类型的相关临床特征和治疗方式。
    方法:作者对过去十年在单一神经外科治疗的CCJAVF患者进行了回顾性分析。这些患者根据其CCJAVF的血管结构进行分类。分析包括对血管结构的评估,临床特征,治疗策略,和结果。
    结果:该研究包括155名患者,平均年龄为56岁,共同显示165个CCJAVF。我们的分类确定了4种不同的CCJAVF类型:硬膜外AVF(19[11.5%]),硬脑膜AVF(98[59.4%]),神经根AVF(33[20.0%]),和髓周AVF(15[9.1%])。根据滴管喂食器的存在进行进一步的区分。主要的瘘管位置在宫颈-1(77.0%)。经常观察到的引流方式是升高的硬膜内引流(52.7%)和下降的硬膜内引流(52.1%)。硬脑膜AVF患者主要表现为静脉性高血压脊髓病,而其他类型的CCJAVF患者的蛛网膜下腔出血发生率较高(P=.012).显微外科是主要的治疗方法,应用于126(76.4%)AVF的管理,而8例(4.8%)AVF仅接受介入栓塞治疗,25例(15.2%)接受介入栓塞和显微外科手术联合治疗.
    结论:CCJAVF可以根据瘘管位置和动脉饲养者来区分。目前,显微外科手术是CCJAVF的首选治疗策略,而介入栓塞在具有特定血管结构或作为显微外科手术前的预处理措施的病例中起着独特的作用。
    OBJECTIVE: Craniocervical junction (CCJ) arteriovenous fistulas (AVFs) are rare. Variability in clinical manifestations and treatment strategies for CCJ AVFs stems from differences in their angioarchitecture. Our study aims to categorize CCJ AVFs based on their angioarchitecture and explore the associated clinical features and treatment modalities for distinct CCJ AVF types.
    METHODS: The authors conducted a retrospective analysis of patients with CCJ AVFs treated at a single neurosurgical facility over the past decade. These patients were classified based on the angioarchitecture of their CCJ AVFs. The analysis included an evaluation of angioarchitecture, clinical characteristics, treatment strategies, and outcomes.
    RESULTS: The study included 155 patients, with a median age of 56 years, collectively manifesting 165 CCJ AVFs. Our classification identified 4 distinct CCJ AVF types: epidural AVFs (19 [11.5%]), dural AVFs (98 [59.4%]), radicular AVFs (33 [20.0%]), and perimedullary AVFs (15 [9.1%]). Further differentiation was applied based on the presence of pial feeders. The predominant fistula location was at cervical-1 (77.0%). Ascending intradural drainage (52.7%) and descending intradural drainage (52.1%) were frequently observed drainage patterns. Patients with dural AVF predominantly presented with venous hypertensive myelopathy, whereas patients with other types of CCJ AVFs showed a higher incidence of subarachnoid hemorrhage (P = .012). Microsurgery was the predominant treatment, applied in the management of 126 (76.4%) AVFs, whereas 8 (4.8%) AVFs exclusively underwent interventional embolization and 25 (15.2%) received a combination of interventional embolization and microsurgical treatment.
    CONCLUSIONS: CCJ AVFs can be distinguished based on the fistula location and the arterial feeders. Currently, microsurgery stands as the preferred treatment strategy for CCJ AVFs, whereas interventional embolization plays a distinctive role in cases with specific angioarchitecture or as a pretreatment measure before microsurgery.
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  • 文章类型: Journal Article
    作者报告了他们对21例表现为腰椎间盘突出症的症状和影像学特征的连续患者的经验;其中,在手术的时候有一个血管环。该手术对14名女性和7名男性进行,平均年龄为39岁。临床投诉包括所有患者的腰椎疼痛伴一条肢体明显的神经根病;在2例中有额外的括约肌功能障碍。症状在平均三个月内出现。在所有患者中,椎间盘通过L5-S1(n=10);L4-L5(n=5)和L3-L4(n=6)开放最小椎板切开术暴露。在16名患者中,而不是椎间盘突出,他们有腰椎硬膜外静脉曲张,而在其余5例中发现了动静脉瘘。在所有情况下,切除血管疾病,其下方的椎间盘完好无损。一名患者术后输血。虽然神经根病功能障碍在所有患者中都得到了改善,4例患者报告了手术后持续的腰椎疼痛.术后成像证实了血管异常和完整椎间盘的分辨率。平均随访时间为47个月。在影像学研究中,腰椎区域的硬膜外静脉曲张或动静脉瘘都可能模仿椎间盘突出。使用通常的技术,他们可以安全地操作。切除异常足以减轻神经根病的症状。
    The authors report their experience with twenty-one consecutive patients who presented with symptoms and imaging characteristics of a herniated lumbar disc; of whom, at the time of surgery had a vascular loop instead. The procedure was performed on 14 women and seven men with a mean age of 39 years. Clinical complaints included lumbar aching with one limb overt radiculopathy in all patients; with additional sphincter dysfunction in two cases. Symptoms had developed within a mean period of three months. In all patients, the disc was exposed through an L5-S1 (n = 10); L4-L5 (n = 5) and L3-L4 (n = 6) open minimal laminotomy. In 16 patients, rather than a herniated disc they had a lumbar epidural varix, while an arterio-venous fistula was found in the remaining five cases. In all cases, the vascular disorder was resected and its subjacent disc was left intact. One patient had a postoperative blood transfusion. While the radiculopathy dysfunction improved in all patients, four patients reported lasting lumbar pain following surgery. The postoperative imaging confirmed the resolution of the vascular anomaly and an intact disc. The mean length of the follow-up period was 47 months. Either epidural varix or arterio-venous fistula in the lumbar area may mimic a herniated disc on imaging studies. With the usual technique they can be operated safely. Resection of the anomaly can be sufficient for alleviating radiculopathy symptoms.
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  • 文章类型: Case Reports
    背景:为了报道起源于子宫的静脉内平滑肌瘤病(IVL)的一种罕见疾病的诊断和治疗,生长在下腔静脉(IVC)并延伸到右心房(RA),伴有盆腔动静脉瘘(AVF)。尽管在非绝经妇女中使用了GnRH激动剂,但这是IVC和RA中首次报道的IVL病例,伴有盆腔AVF继发的肺良性转移性平滑肌瘤(PBML)。
    方法:患者是一名50岁的绝经前妇女,有肺良性转移性平滑肌瘤(PBML)手术切除和抗雌激素保守药物治疗5年的病史。然而,患者在IVC中发展为IVL,髂内静脉和RA伴有AVF。阴道超声联合超声心动图和CT静脉成像辅助诊断IVL合并AVF,组织病理学和免疫组织化学最终证实了诊断。患者最终接受了联合子宫切除术,双侧附件切除术,在没有体外循环和胸骨切开术的情况下切除IVC和RA中的肿瘤。
    结论:即使使用抗雌激素药物,子宫和卵巢切除不完全,BML可能难以控制,由纤维瘤手术引起的医学诱导的AVF可能会加速该过程和IVL的发展。
    BACKGROUND: To report the diagnosis and treatment of a rare disease of intravenous leiomyomatosis (IVL) originating from the uterus, growing in the inferior vena cava (IVC) and extending into the right atrium (RA) associated with a pelvic arteriovenous fistula (AVF). This is the first reported case of IVL in the IVC and RA with pulmonary benign metastasizing leiomyoma (PBML) secondary to a pelvic AVF despite the use of GnRH agonists in a non-menopausal woman.
    METHODS: The patient was a 50-year-old premenopausal woman with a history of surgical resection for and anti-estrogen conservative drug for pulmonary benign metastasizing leiomyoma (PBML) 5 years. The patient nevertheless developed IVL in the IVC, internal iliac vein and RA accompanied by AVF. Vaginal ultrasound combined with echocardiography and Computerized tomographic venography imaging assists in the diagnosis of IVL combined with AVF, with histopathology and immunohistochemistry ultimately confirming the diagnosis. the patient ultimately was performed with a combination of hysterectomy, bilateral adnexectomy, and resection of tumors in the IVC and RA without cardiopulmonary bypass and sternotomy.
    CONCLUSIONS: BML may be difficult to control with incomplete removal of the uterus and ovaries even with the use of anti-estrogenic medications, and medically induced AVF resulting from fibroid surgery may accelerate this process and the development of IVL.
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  • 文章类型: Journal Article
    背景:慢性肾脏病(CKD)影响全球13%的人口,并且由于ESRD而需要肾脏替代疗法。血液透析(HD)是ESRD患者最常见的透析方式,但由于高发病率和死亡率,建立血管通路具有挑战性.动静脉瘘(AVF)是血管通路的黄金标准,但许多失败是由于吻合血流动力学,静脉直径,和吻合缝合技术。进行了一项前瞻性研究,以评估两种连续缝合技术的影响,锚技术和降落伞技术,关于AVF的初始结果。
    方法:这是随机的,对照研究包括在我们中心进行AVF创建的成年患者。我们将患者分为两组:锚和降落伞。四名熟练的血管通路外科医生执行了该程序。主要目标是AVF的功能成熟,定义为准备插管的AVF瘘,插管静脉长度至少为10厘米,直径大于6毫米,深度小于6毫米,和600mL/min的流速。次要目标包括通畅性和并发症,如出血,感染,偷窃综合征,吻合部位的动脉瘤扩张。术后和门诊随访期间立即评估AVF。进行双重扫描以测量不同间隔的流量。所有患者均提供适当的书面同意书。
    结果:该研究涉及186名患者,86被排除在外。100人被随机分组,5例失去随访,3例在12个月内死亡。随访持续到2024年1月,平均为8.6个月。与Anchor相比,降落伞技术显示出更高的技术成功(p值=0.046)和30天的主要通畅性(p值=0.014)。但是两组在6周时的功能成熟没有统计学意义(p值=0.352)。降落伞技术的血肿率高于锚杆技术(p值=0.025),而其他并发症如术中出血,术后出血,假性动脉瘤形成,血栓形成,偷窃综合征,和血清瘤形成没有显着差异。9名患者,其中五人是糖尿病患者,接受了保守的治疗,表现为轻度至中度盗血综合征。这表明糖尿病患者中盗血综合征的风险增加。
    结论:用于AVF创作的降落伞技术提供了更好的技术成功和短期的主要通畅性结果,而降落伞和锚定技术对于长期功能成熟和总体并发症发生率同样有效。
    BACKGROUND: Chronic kidney disease (CKD) affects 13% of the global population and requires renal replacement therapy due to ESRD. Hemodialysis (HD) is the most common dialysis modality for ESRD patients, but establishing vascular access is challenging due to high morbidity and mortality rates. Arteriovenous fistulas (AVFs) are the gold standard for vascular access, but many fail due to anastomotic hemodynamics, vein diameter, and anastomatic suture technique. A prospective study was conducted to evaluate the impact of two continuous suturing techniques, the anchor technique and the parachute technique, on AVFs\' initial outcomes.
    METHODS: This randomized, controlled study involved adult patients who presented for AVF creation at our center. We divided the patients into two groups: anchors and parachutes. Four skilled vascular access surgeons performed the procedures. The primary goal was functional maturation of the AVF, defined as an AVF fistula ready to be cannulated with a cannulating vein length of at least 10 cm, a diameter of more than 6 mm, a depth of less than 6 mm, and a flow rate of 600 mL/min. Secondary goals included patency and complications such as bleeding, infection, steal syndrome, and aneurysmal dilatation at the anastomosis site. AVFs were evaluated immediately after surgery and during follow-up visits at the outpatient clinic. A duplex scan was performed to measure flow at various intervals. All patients provided appropriate written consent.
    RESULTS: The study involved 186 patients, with 86 excluded. 100 were randomized, with 5 cases losing follow-up and 3 deaths within 12 months. The follow-up continued until January 2024, with a mean of 8.6 months. The Parachute technique shows higher technical success (p value = 0.046) and primary patency at 30 days (p value = 0.014) compared to Anchor, but there is no statistical significance between both groups regarding functional maturation at 6 weeks (p value = 0.352). The parachute technique has a higher hematoma rate than the anchor technique (p value = 0.025), while other complications like intra-operative bleeding, postoperative bleeding, pseudoaneurysm formation, thrombosis, steal syndrome, and seroma formation show no significant differences. Nine patients, five of whom were diabetic and underwent conservative management, exhibited mild to moderate steal syndrome. This suggests an increased risk of steal syndrome among diabetic patients.
    CONCLUSIONS: The parachute technique for AVF creation offers better technical success and short-term primary patency outcomes, while both parachute and anchor techniques are equally effective for long-term functional maturation and overall complication rates.
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  • 文章类型: Case Reports
    同种异体移植活检是移植肾脏管理的基石。这是一个安全的程序,经常在门诊进行。一种罕见的并发症是活检后动静脉瘘(AVF)的形成。我们在此报告两例血管内活检后AVF。选择性栓塞是治疗同种异体肾活检后AVF的安全有效方法。
    Allograft biopsy is a cornerstone in the management of transplanted kidneys. It is a safe procedure, often performed in the outpatient setting. A rare complication is formation of a postbiopsy arteriovenous fistula (AVF). We present here a report of two cases of postbiopsy AVFs treated endovascularly. Selective embolization is a safe and effective method of treatment of postbiopsy AVFs in renal allografts.
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  • 文章类型: Letter
    暂无摘要。
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  • 文章类型: Journal Article
    血液透析疗法是一种体外循环疗法,可替代肾功能。在日本,患者接受这种有效的四小时治疗,每周三次,允许他们维持几乎相当于健康个体的社交生活。在治疗之前,进行两次穿刺以建立体外循环,高的血液流速对于确保有效的治疗至关重要。利用通过动静脉瘘(AVF)手术产生的专门血管来实现高血液流速。虽然AVF允许安全有效的透析治疗,AVF狭窄导致透析中的严重问题。为了及早发现这种异常的血流,听诊和触诊方法在医院中广泛使用。然而,这些方法只能提供AVF条件的定性判断,所以结果不能在其他医生和工作人员之间分享。此外,由于传统方法需要与皮肤接触,一些问题需要考虑感染和低重现性。在我们之前的研究中,我们提出了一种使用非接触式光学成像技术进行听诊的替代方法。本研究旨在基于开发的非接触式设备,使用Thrill波形分析构建可靠的AVF狭窄检测方法,以解决接触式触诊方法的问题。本文演示了正常AVF组非接触成像的性能验证(共206个数据,75名患者,平均年龄:69.1岁),在可治疗的狭窄组中(总共107个数据,17名患者,平均年龄:70.1岁)。Mann-WhitneyU检验的实验结果表明,正常组和异常组之间存在显着差异(p=0.0002),这表明所提出的方法作为一种新的可能替代触诊的有效性。
    Hemodialysis therapy is an extracorporeal circulation treatment that serves as a substitute for renal function. In Japan, patients receive this efficient four-hour treatment, three times per week, allowing them to maintain a social life nearly equivalent to that of healthy individuals. Before the treatment, two punctures are performed to establish extracorporeal circulation, and a high blood flow rate is essential to ensure efficient therapy. Specialized blood vessels created through arteriovenous fistula (AVF) surgery are utilized to achieve high blood flow rates. Although the AVF allows safe and efficient dialysis treatment, AVF stenosis leads to a serious problem in dialysis. To early detect this abnormal blood flow, auscultation and palpation methods are widely used in hospitals. However, these methods can only provide qualitative judgment of the AVF condition, so the results cannot be shared among other doctors and staff. Additionally, since the conventional methods require contact with the skin, some issues require consideration regarding infection and low reproducibility. In our previous study, we proposed an alternative method for auscultation using non-contact optical imaging technology. This study aims to construct a reliable AVF stenosis detection method using Thrill waveform analysis based on the developed non-contact device to solve the problem with the contact palpation method. This paper demonstrates the performance validation of the non-contact imaging in the normal AVF group (206 total data, 75 patients, mean age: 69.1 years) and in the treatable stenosis group (107 total data, 17 patients, mean age: 70.1 years). The experimental results of the Mann-Whitney U test showed a significant difference (p=0.0002) between the normal and abnormal groups, which indicated the effectiveness of the proposed method as a new possible alternative to palpation.
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