背景:适配体并不是一个新概念,然而,这几乎没有被医学界讨论过。适体是有效的,新的识别分子开始在诊断领域的一项新技术中发挥作用。自90年代发现适体以来,它们几乎开始了诊断测定的革命。(RaduS.世界各地当前和以前的疾病暴发,美国新闻与世界报道。2020年3月13日[引用2024年6月17日]。可从以下网址获得:https://www.usnews.com/news/best-countries/slideshows/20-大流行和流行病-根据-who)提供了世卫组织报告的大流行和流行病概述。有趣的是,注意到几种地方病和流行病。基孔肯雅,霍乱,克里米亚-刚果出血热,埃博拉病毒病,亨德拉病毒感染,流感,拉沙热,马尔堡病毒病,脑膜炎,MERS-CoV(中东呼吸综合征冠状病毒)猴痘,尼帕病毒感染,新型冠状病毒,瘟疫,裂谷热,SARS(严重急性呼吸系统综合症)天花,图拉血症,黄热病,和寨卡病毒病已被世卫组织鉴定,并正在探索适体技术在其鉴定中的适用性。
目的:早期诊断是控制流行病或流行性疾病的最重要的必要条件之一。然而,这些疾病的大多数诊断测试仅在三级护理中心提供。这篇综述的目的是讨论适体技术的潜力,简单,具体,敏感,和具有成本效益的诊断分析,可用于远程和现场条件。
背景:这里,我们讨论了在诊断感染性和非感染性疾病中有用的适体和适体工程的最新进展和方法。这篇评论还讨论了一些传感发现,这些发现是使用光学和电化学传感器的先进工程和技术的礼物。还有很长的路要走,我们需要考虑适体-aptasensor技术面临的技术挑战。
BACKGROUND: Aptamers are not so new a concept, however, it is scarcely discussed by medical fraternity. Aptamers are potent, new identification molecules set to rope in a new technique in the diagnostic arena. Aptamers have started almost a revolution in diagnostic assays since their discovery in the 90s. (Radu S. Current and previous disease outbreaks around the world, U.S. News & World Report. 2020 Mar 13 [cited 2024 Jun 17]. Available from: https://www.usnews.com/news/best-countries/slideshows/20-pandemic-and-epidemic-diseases-according-to-who) provides an overview of pandemics and epidemics as reported by the WHO. It is interesting to note that several endemic and epidemic diseases viz. Chikungunya, Cholera, Crimean-Congo haemorrhagic fever, Ebola virus disease, Hendra virus infection, Influenza, Lassa fever, Marburg virus disease, Meningitis, MERS-CoV (Middle East Respiratory Syndrome Corona Virus), Monkeypox, Nipah virus infection, Novel coronavirus, Plague, Rift Valley fever, SARS (Severe Acute Respiratory Syndrome), Smallpox, Tularaemia, Yellow fever, and Zika virus disease have been identified by the WHO and are being explored for applicability of aptamer technology in their identification.
OBJECTIVE: One of the most important necessities to control epidemic or pandemic diseases is early diagnosis. However, the majority of the diagnostic tests for these diseases are available only in tertiary care centres. The objective of this review is to discuss the potential of aptamer technology to provide undemanding, simple, specific, sensitive, and cost-effective diagnostic assays that are useable in remote and field conditions.
BACKGROUND: Here, we discuss recent advances and approaches in aptamer and aptamer engineering useful in the diagnosis of infectious and non-infectious conditions. This review also discusses a few sensing discoveries which are a gift of advanced engineering and technology using optical and electrochemical aptasensors. It\'s still a long way to go, and we need to take into account the technological challenges being faced by aptamer-
aptasensor technology.