背景:APOE基因编码脂质代谢中的多功能蛋白,也与炎症标志物有关。2型糖尿病(T2D)是一种与血糖升高有关的复杂代谢性疾病,甘油三酯和VLDL,并与不同的血脂异常相关。这项研究的目的是分析APOE基因型是否可以确定在一大群工人中发展T2D的风险。
方法:使用来自阿拉贡工人健康研究(AWHS)(n=4895)的数据来调查血糖水平与APOE基因型之间的关系。AWHS队列中的所有患者在过夜禁食后抽血,并在抽血的同一天进行实验室检查。通过面对面访谈评估饮食和身体评估。通过Sanger测序方法确定APOE基因型。
结果:APOE基因型与血糖谱之间的关系表明,Hb1Ac,胰岛素和HOMA水平似乎与APOE基因型无关(分别为p=0.563,p=0.605,p=0.333和p=0.276).此外,T2D患病率未显示与APOE基因型相关(p=0.354).同样,血糖水平和T2D患病率未显示与APOE等位基因相关.轮班工作对血糖状况有一些影响,表明夜班工人的葡萄糖水平明显较低,胰岛素和HOMA(p<0.001)。然而,APOE基因型并没有显示出不同性别的血糖参数浓度的差异,年龄和BMI,工作班次和饮食参数。
结论:血糖谱和T2D患病率与APOE基因型没有任何显著关联。此外,个人,在非轮换夜班工作的人显示出显著较低的血糖水平,而早上-下午-夜班的工人表现出明显更高的价值。
BACKGROUND: APOE gene encoded a multifunctional protein in lipid metabolism, also associated with inflammatory markers. Type 2 diabetes (T2D) is a complex metabolic disease related to increased blood glucose, triglycerides and VLDL and associated with different dyslipidaemias. The aim of this study was to analyze whether the APOE genotype could determining the risk of developing T2D in a large cohort of workers.
METHODS: Data from the Aragon Workers Health Study (AWHS) (n=4895) were used to investigate the relationship between glycemic levels and APOE genotype. All patients in the AWHS cohort had their blood drawn after an overnight fast and laboratory tests were performed on the same day as the blood drawn. Dietary and physical assessment was assessed by face-to-face interview. APOE genotype was determined by the Sanger sequencing method.
RESULTS: The relationship between APOE genotype and glycemic profile showed that glucose, Hb1Ac, insulin and HOMA levels did not seem to be associated with the APOE genotype (p=0.563, p=0.605, p=0.333 and p=0.276, respectively). In addition, the T2D prevalence did not show an association with the APOE genotype (p=0.354). Along the same lines, blood glucose levels and T2D prevalence did not show association with the APOE allele. Shift work had some effect on the glycaemic profile, showing that night shift workers have significantly lower levels of glucose, insulin and HOMA (p<0.001). However, the APOE genotype did not show difference in the concentration of glycaemic parameters adjusting by sex, age and BMI, work shift and dietary parameters.
CONCLUSIONS: Glycemic profile and T2D prevalence did not show any significant association with the APOE genotype. Besides, individuals, who worked in non-rotating night shift showed significantly lower glycemic levels, while workers in the morning-afternoon-night shift showed significantly higher values.