Apgar score

阿普加评分
  • 文章类型: Journal Article
    背景:研究表明,病例助产会增加阴道分娩的机会,但在标准护理中阴道分娩率高的情况下可能并非如此。这项研究调查了病例助产与分娩方式之间的关系,劳动干预,以及丹麦一家大型产科病房的孕产妇和新生儿结局。
    方法:队列研究,包括现场医疗记录,单身出生从2018年6月至2022年2月。与标准助产护理相比,暴露是个案助产护理。主要结果是出生模式,次要结局是其他分娩结局。通过对数二项回归估计具有95%置信区间(CI)的调整风险比(aRR)。
    结果:在16,110例怀孕中,3162例孕妇(19.6%)接受了个案助产护理。病例助产与较少的计划剖腹产(aRR0.63[95%CI0.54-0.74])和紧急剖腹产(aRR0.86[95%CI0.75-0.95])相关。引产没有差异,使用硬膜外镇痛,催产素增强,或肛门括约肌撕裂被观察到。病例助产进行了更多的羊膜切除术(RR1.14[95%CI1.02-1.27]),倾向于进行更多的外切术(RR1.19[95%CI0.96-1.48])。产后出血(aRR0.90[95%CI0.82-0.99])和低Apgar评分的可能性较小(aRR0.54[95%CI0.37-0.77]),和早期出院的可能性更大(RR1.22[95%CI1.17-1.28])。
    结论:在病例助产护理中,观察到较高的阴道分娩率,而不良结局没有增加,主要是由于计划剖宫产的可能性较低。此外,出生时Apgar得分较低的孩子较少。
    BACKGROUND: Research has shown caseload midwifery to increase the chance of vaginal birth, but this may not be the case in settings with high vaginal birth rates in standard care. This study investigated the association between caseload midwifery and birth mode, labor interventions, and maternal and neonatal outcomes at a large obstetric unit in Denmark.
    METHODS: Cohort study including medical records on live, singleton births fr om June 2018 until February 2022. Exposure was caseload midwifery care compared with standard midwifery care. The primary outcome was birth mode, and secondary outcomes were other outcomes of labor. Adjusted risk ratios (aRR) with 95% confidence intervals (CI) were estimated by log-binomial regression.
    RESULTS: Among 16,110 pregnancies, 3162 pregnancies (19.6%) received caseload midwifery care. Caseload midwifery was associated with fewer planned cesareans (aRR 0.63 [95% CI 0.54-0.74]) and emergency cesareans (aRR 0.86 [95% CI 0.75-0.95]). No differences in labor induction, use of epidural analgesia, oxytocin augmentation, or anal sphincter tears were observed. Caseload midwifery performed more amniotomies (aRR 1.14 [95% CI 1.02-1.27]) and tended to perform more episiotomies (aRR 1.19 [95% CI 0.96-1.48]). Postpartum hemorrhage (aRR 0.90 [95% CI 0.82-0.99]) and low Apgar score were less likely (aRR 0.54 [95% CI 0.37-0.77]), and early discharge more likely (aRR 1.22 [95% CI 1.17-1.28]) in caseload midwifery.
    CONCLUSIONS: In caseload midwifery care, a higher vaginal birth rate was observed with no increase in adverse outcomes, mainly due to a lower likelihood of planned cesarean. Also, fewer children were born with low Apgar scores.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    背景:剖宫产是当今产科实践中最常见的手术之一,是一种挽救母亲和胎儿生命的手术。剖腹产是传统的分类,作为选择性剖宫产或紧急剖宫产。目的比较择期剖宫产和急诊剖宫产的母婴结局,以便采取措施降低母婴发病率和死亡率。
    方法:本研究纳入了一项描述性研究,包括400名剖腹产孕妇。根据研究所的适应症和方案,对患者进行选择性或紧急剖宫产。包括在研究中。
    结果:在研究期间,共有1080例分娩。女性平均年龄为29.21±4.07岁。在400例剖宫产病例中,只有2.8%的人有伤口感染,3.8%有发烧,4.8%尿路感染(UTI),而没有妇女观察到产后出血(PPH)和孕产妇死亡。关于胎儿结局,16%的新生儿重症监护病房(NICU)入院,出生窒息为2.3%,Apgar评分差2.5%,未观察到新生儿死亡。发烧率,UTI,伤口感染,与择期剖腹产相比,急诊部门的复苏需求和Apgar评分差明显较高,而NICU入院无统计学意义。紧急剖宫产最常见的指征是胎儿着装和以前的LSCS。
    结论:与择期剖宫产相比,急诊剖宫产与产妇和围产期并发症增加相关。
    BACKGROUND: Cesarean section is one of the most common procedures performed in obstetric practice today and is a lifesaving surgery for mother and fetus. Cesarean sections are classified traditionally, as elective cesarean section or emergency cesarean. The purpose of this study is to compare the maternal and neonatal outcomes in elective and emergency cesarean section so that measures can be taken to reduce maternal and neonatal morbidity and mortality.
    METHODS: A descriptive study including 400 pregnant women who underwent caesarean section were included in this study. Patients were subjected to elective or emergency cesarean section as per the indication and protocol of institute. were included in the study.
    RESULTS: During the study period there were total 1080 deliveries. The average age of the women was 29.21±4.07 years. Of the 400 cesarean section cases, only 2.8% had wound infection, 3.8% had fever, 4.8% urinary tract infection (UTI) whereas no women had observed with post-partum hemorrhages (PPH) and maternal death. Regarding fetal outcome, neonatal intensive care unit (NICU) admission was observed in 16%, birth asphyxia was 2.3% poor Apgar score 2.5% and neonatal death was not observed. Rate of fever, UTI, wound infection, need of resuscitation and poor Apgar score was significantly high in emergency section than elective caesarean section whereas NICU admission was not statistically significant. The most common indication of emergency cesarean section were fetal dress and for previous LSCS.
    CONCLUSIONS: Emergency cesarean was associated with increased maternal and perinatal complications than in elective cesarean section.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    背景:在临床经验中,枕骨后(OP)位置比枕骨前(OA)位置具有更长的产程,但是很少有研究调查产程与胎儿位置之间的关系。我们旨在使用生存方法比较当代人群中OP分娩与OA分娩活跃期的持续时间。次要目的是比较手术干预的频率,产科肛门括约肌损伤(OASIS),产后出血,OA分娩的OP和新生儿结局。
    方法:我们从2012年到2022年在挪威的三家大学医院进行了一项历史队列研究。头部有一个胎儿的女性,既往剖宫产和胎龄≥37周均不符合诊断标准,并将其分为Robson十组分类系统(TGCS)的前4组.我们估计了平均持续时间,并使用生存分析计算了分娩的风险比(HR)。剖腹产和工具性阴道分娩被审查。
    结果:研究人群包括112,019名女性,105571(94.2%)在OA和6448(5.8%)在OP位置。在所有四个TGCS组中,胎儿处于OP位置的妇女的分娩活动期的估计平均持续时间更长。在硬膜外镇痛和催产素增强的分层分析中,OP组的估计持续时间更长。图形摘要说明了与合并的TGCS组1和2a中的OA位置相比,OP中的交付概率,作为时间的函数。与TGCS组1的OA位置相比,在OP位置分娩的胎儿的未调整HR为0.33(95%CI0.31-0.36),在2a组中为0.25(95%CI0.21-0.27),第3组中为0.70(95%CI0.67-0.73),第4a组中为0.61(95%CI0.55-0.67),分别。无论是产妇年龄,胎龄,BMI和出生体重都有混杂效应。在所有四组中,OP位置的手术分娩率和OASIS率都较高。
    结论:我们发现在所有四个TGCS组中,胎儿以OP位置分娩的妇女的活跃期持续时间更长。
    BACKGROUND: In clinical experience, occiput posterior (OP) position is associated with longer labor duration than occiput anterior (OA) position, but few studies have investigated the association between labor duration and fetal position. We aimed to compare duration of the active phase of labor in OP deliveries with OA deliveries in a contemporary population using survival methods. Secondary aims were to compare the frequencies of operative interventions, obstetric anal sphincter injuries (OASIS), postpartum hemorrhage, and newborn outcomes in OP with OA deliveries.
    METHODS: We did a historical cohort study in three university hospitals in Norway from 2012 to 2022. Women with a single fetus in cephalic presentation, no previous cesarean section and gestational age ≥37 weeks were eligible and stratified into the first four groups of the Robson ten-group classification system (TGCS). We estimated the mean duration and calculated the hazard ratio (HR) for delivery using survival analyses. Cesarean sections and instrumental vaginal deliveries were censored.
    RESULTS: The study population comprised 112 019 women, 105 571 (94.2%) were delivered in OA and 6448 (5.8%) in OP position. The estimated mean duration of the active phase of labor was longer in women with the fetus in OP position in all four TGCS groups. The estimated duration was longer in the OP groups in analyses stratified with respect to epidural analgesia and oxytocin augmentation. The graphical abstract illustrates the probability of delivery in OP compared with OA position in merged TGCS groups 1 and 2a, as a function of time. The unadjusted HR was 0.33 (95% CI 0.31-0.36) for fetuses delivered in OP position compared with OA position in TGCS group 1, 0.25 (95% CI 0.21-0.27) in group 2a, 0.70 (95% CI 0.67-0.73) in group 3, and 0.61 (95% CI 0.55-0.67) in group 4a, respectively. Neither maternal age, gestational age, BMI nor birthweight had confounding effect. Operative delivery rates and OASIS rates were higher in OP position in all four groups.
    CONCLUSIONS: We found longer duration of the active phase of labor in women with the fetus delivered in OP position in all four TGCS groups.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    目的:本研究的目的是评估治疗性低温对5分钟Apgar评分<7的新生儿的孕产妇和围产期结局的影响。
    方法:对55例新生儿进行了回顾性队列研究,这些新生儿在第5分钟时Apgar评分<7(35例无治疗性低温和20例治疗性低温)来自33至41周低风险妊娠。Apgar评分是由产房的新生儿专家通过客观评估计算得出的。分娩室的新生儿专家指出了治疗性低温,根据巴西儿科学会制定的协议。比较两组(无低温和有低温治疗)的孕产妇和围产期结局。
    结果:第5分钟Apgar评分<7的比率为1.02%。两组(无治疗性低温)在母体/围产期并发症方面未观察到统计学差异。在第5分钟Apgar评分<7的新生儿中,母体/围产期并发症的存在并未增加新生儿治疗性低温的比值比。
    结论:第5分钟Apgar评分<7的比率较低,并且与任何孕产妇/围产期并发症无关。接受治疗性低温治疗的新生儿和未接受治疗的新生儿在孕产妇/围产期并发症方面没有显着差异。
    OBJECTIVE: The aim of this study was to evaluate the impact of therapeutic hypothermia on maternal and perinatal outcomes in newborns with Apgar score<7 at the 5th min.
    METHODS: A retrospective cohort study was carried out with 55 newborns who had an Apgar score<7 at the 5th min (35 without and 20 with therapeutic hypothermia) from low-risk pregnancies between 33 and 41 weeks gestation. The Apgar score was calculated through an objective assessment by a neonatologist in the delivery room. Therapeutic hypothermia was indicated by a neonatologist in the delivery room, according to the protocol established by the Brazilian Society of Pediatrics. The maternal and perinatal outcomes of both groups (without and with therapeutic hypothermia) were compared.
    RESULTS: A rate of Apgar score<7 at the 5th min was 1.02%. No statistical differences were observed between the two groups (without and with therapeutic hypothermia) regarding maternal/perinatal complications. The presence of maternal/perinatal complications did not increase the odds ratio of neonatal therapeutic hypothermia in newborns with Apgar score<7 at the 5th min.
    CONCLUSIONS: The rate of Apgar score<7 at the 5th min was low, and it was not associated with any maternal/perinatal complications. There was no significant difference in maternal/perinatal complications between newborns who received therapeutic hypothermia and those who did not.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    BACKGROUND: Admission cardiotocography (CTG), a noninvasive procedure, is used to indicate the state of oxygenation of the fetus on admission into the labor ward.
    OBJECTIVE: This study assessed the association of admission CTG findings with neonatal outcome at a tertiary health facility.
    METHODS: A prospective, observational study of 206 pregnant women who were admitted into the labor ward with singleton live pregnancies. Information on the demographic characteristics, obstetrics and medical history, admission CTG tracing, and neonatal outcome was obtained using a structured data collection form. Data were analyzed using the SPSS software version 20.0 with the level of significance set at P < 0.05.
    RESULTS: The admission CTG findings were normal in 73.3%, suspicious in 13.6%, and pathological in 13.1% of the women. The occurrence of low birth weight, special care baby unit (SCBU) admission, asphyxiated neonates, neonatal death, and prolonged hospital admission was significantly more frequent among those with pathological admission CTG results compared with normal and suspicious results (P < 0.05). The incidence of vaginal delivery was more common when the CTG findings were normal, whereas all women with pathological CTG result had a cesarean delivery.
    CONCLUSIONS: Admission CTG was effective in identifying fetuses with a higher incidence of perinatal asphyxia. Neonatal outcome such as low birth weight, APGAR score, SCBU admission, and prolonged hospital admission was significantly associated with pathological CTG findings. In the absence of facilities for further investigations, prompt intervention for delivery should be ensured if admission CTG is pathological.
    Résumé Contexte:La cardiotocographie d’admission (CTG), une procédure non invasive, est utilisée pour indiquer l’état d’oxygénation du fœtus lors de son admission en salle de travail.Objectif:Cette étude a évalué l’association entre les résultats du CTG à l’admission et l’issue néonatale dans un établissement de santé tertiaire.Matériels et méthodes:Une étude observationnelle prospective portant sur 206 femmes enceintes admises en salle de travail avec des grossesses vivantes uniques. Des informations sur les caractéristiques démographiques, les antécédents obstétricaux et médicaux, le traçage CTG à l’admission et les résultats néonatals ont été obtenues à l’aide d’un formulaire de collecte de données structuré. Les données ont été analysées à l’aide du logiciel SPSS version 20.0 avec le niveau de signification fixé à P <0,05.Résultats:Les résultats du CTG à l’admission étaient normaux chez 73,3 %, suspects chez 13,6 % et pathologiques chez 13,1 % des femmes. La survenue d’un faible poids à la naissance, d’une admission dans une unité de soins spéciaux pour bébés (SCBU), de nouveau-nés asphyxiés, de décès néonatals et d’une hospitalisation prolongée était significativement plus fréquente chez les personnes ayant des résultats CTG d’admission pathologiques par rapport aux résultats normaux et suspects (P < 0,05). L’incidence des accouchements par voie basse était plus fréquente lorsque les résultats du CTG étaient normaux, alors que toutes les femmes présentant un résultat pathologique du CTG avaient accouché par césarienne.Conclusion:L’admission CTG s’est avérée efficace pour identifier les fœtus présentant une incidence plus élevée d’asphyxie périnatale. Les résultats néonatals tels qu’un faible poids à la naissance, le score APGAR, l’admission au SCBU et l’hospitalisation prolongée étaient significativement associés aux résultats pathologiques du CTG. En l’absence de moyens permettant des investigations plus approfondies, une intervention rapide pour l’accouchement doit être assurée si l’admission du CTG est pathologique.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    背景:在全球范围内,在过去的30年里,围产期死亡率大幅下降。然而,在撒哈拉以南非洲国家,围产期死亡率仍然是公共卫生负担。因此,这项研究旨在确定贝尼市围产期死亡率和与围产期死亡率相关的因素,刚果民主共和国东北部。
    方法:对2022年1月2日至5月31日在贝尼综合转诊医院记录的1394例分娩进行了一项基于医院的回顾性横断面研究。这项研究是在北基伍省充满冲突的贝尼市进行的。使用OpenEpi和SPSS版本22进行分析。进行二元和多变量逻辑回归分析。使用具有95%置信区间的几率来衡量关联强度。
    结果:研究结果表明,1394名参与者中有60.7%的人年龄在21岁以下,和95.1%(1325)贝尼居民。围产期死亡率为每1000例活产42.3例。大多数(51)经历围产期死亡的产后妇女与他们的同龄人相比没有围产期死亡史。多因素分析显示,出生体重(AoR=0.082,95%CI0.014-0.449,p<0.05)和第10分钟Apgar评分(AoR=0.082,95%CI0.000-0.043,p<0.05)与围产期死亡率显着相关。
    结论:贝尼综合转诊医院围产期死亡率高,每100例新生儿中约有4例仍然是一个令人不安的公共卫生问题,其中归因于低出生体重和Apgar评分。这项研究可能有助于政策制定者和医疗保健提供者设计预防性干预措施。
    BACKGROUND: Globally, perinatal mortality rates have decreased considerably in the last 30 years. However, in sub-Saharan African countries perinatal mortality remains a public health burden. Therefore, this study aimed to determine the Perinatal Mortality Rate and the factors associated with perinatal mortality in Beni City, Northeastern Democratic Republic of Congo.
    METHODS: A hospital-based retrospective cross-sectional study was conducted among 1394 deliveries that were documented in Beni General Referral Hospital from 2 January to May 31, 2022. The study was done in the conflict-ridden Beni city of the North Kivu Province. Analysis was done using Open Epi and SPSS version 22. Binary and Multivariate logistic regression analyses were performed. Odds ratio with 95% confidence interval was used to measure strength of association.
    RESULTS: Findings indicate that 60.7% of 1394 participants were below the age of 21 years, and 95.1% (1325) Beni residents. The Perinatal Mortality Rate was 42.3 per 1000 live births. Majority (51) of the postpartum women who experienced perinatal mortality didn`t have a history of perinatal mortality as compared to their counterparts. Multivariable analysis revealed that birth weight (AoR = 0.082, 95% CI 0.014-0.449, p < 0.05) and Apgar score in the 10th minute (AoR = 0.082, 95% CI 0.000- 0.043, p < 0.05) were significantly associated with Perinatal mortality.
    CONCLUSIONS: The high perinatal mortality rate in Beni General Referral Hospital, approximately four in every 100 births remains a disturbing public health concern of which is attributable to low birth weight and Apgar score. This study may help policy-makers and healthcare providers to design preventive interventions.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    目的:了解早产(PTB)的患病率和生存率对于制定医疗保健计划至关重要,改善新生儿护理,加强母婴健康,监测长期结果,指导政策和宣传工作。
    方法:新生儿重症监护病房(NICU)收治的早产儿的医疗记录,在妇幼医院(MCH)诊断为早产儿,AlKharj,沙特阿拉伯,在2018年1月至2022年12月期间进行了审查。数据收集了出生体重(BW),性别,活产婴儿的数量,胎龄,死亡率,国籍,APGAR评分,在NICU的停留时间,和母亲的细节。
    结果:在2018年至2022年期间,共发现9809例活产,其中139例(3.9%)早产。纳入样本的总死亡率为7.19%,而根据BW,极低出生体重(ELBW)的死亡率为38.4%。最常见的产时并发症是不正常(15.1%),胎盘并发症(4.3%),和脊髓并发症(3.6%)。
    结论:这项研究为该国PTB的患病率提供了有价值的见解,特别关注极度早产婴儿的脆弱性。
    OBJECTIVE: To understand the prevalence and survival rates of preterm birth (PTB) is of utmost importance in informing healthcare planning, improving neonatal care, enhancing maternal and infant health, monitoring long-term outcomes, and guiding policy and advocacy efforts.
    METHODS: The medical records of preterm infants admitted to the Neonatal Intensive Care Unit (NICU) with a diagnosis of prematurity at the Maternity and Children\'s Hospital (MCH), Al Kharj, Saudi Arabia, were reviewed between January 2018 and December 2022. Data were collected on birth weight (BW), gender, number of live births, gestational age, mortality, nationality, APGAR score, length of stay in the NICU, and maternal details.
    RESULTS: A total of 9809 live births were identified between 2018 and 2022, of which 139 (3.9%) were born preterm. The overall mortality rate of the included sample was 7.19%, whereas the mortality rate according to BW was 38.4% of those born with extremely low birth weight (ELBW). The most common intrapartum complications were malpresentation (15.1%), placental complications (4.3%), and cord complications (3.6%).
    CONCLUSIONS: This study provides valuable insights into the prevalence of PTB in the country, particularly focusing on the vulnerability of extremely preterm babies.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    背景:快速准确地评估新生儿窒息对于预防潜在的致命结局至关重要。因此,护理专业学生必须掌握出生后立即评估新生儿状况的技能,并实施适当的干预措施。虚拟现实(VR)模拟教育已成为护理教育的一种有前途的工具,提供重复和可定制的临床培训,同时确保患者安全并克服时空限制。
    目的:本研究调查了基于非接触式手跟踪的沉浸式VR新生儿Apgar评分程序的效果,改编自体验式学习理论。
    方法:一项非随机对照试验,进行了准实验设计。
    方法:该研究于2023年7月至10月在两所护理学校进行。
    方法:参与者包括持有护理学学士学位的护理专业学生,具有三到四年的经验,并成功完成了新生儿护理理论课程。此外,在进入护理学校之前,具有至少六个月在新生儿病房或分娩室工作经验的个人符合资格。
    方法:将参与者分为三组:VR组(n=27)接受基于非接触式手跟踪的沉浸式VR新生儿Apgar评分训练;模拟组(n=28)接受面对面的Apgar评分模拟训练;对照组(n=26)接受Apgar评分标准指导。VR中的分数变化,模拟,使用ANOVA与SPSS-WIN27.0进行统计学比较。
    结果:VR组在知识上有了显著的提高,学习满意度,自信,沉浸,和动机与模拟组和对照组相比。此外,VR组的满意度明显高于模拟组。
    结论:基于手跟踪的沉浸式VR新生儿Apgar评分计划代表了一种创新和有效的教育工具,优先考虑母亲和婴儿的隐私和权利。它有可能取代传统的产房临床培训,这是基于观察和有限的。
    The rapid and accurate assessment of neonatal asphyxia is critical to preventing potentially fatal outcomes. Therefore, nursing students must acquire the skills to assess newborn conditions immediately after birth and implement appropriate interventions. Virtual reality (VR) simulation education has emerged as a promising tool for nursing education, offering repetitive and customizable clinical training while ensuring patient safety and overcoming spatiotemporal limitations.
    This study investigated the effects of a contactless hand-tracking-based immersive VR neonatal Apgar scoring program, adapted from experiential learning theory.
    A non-randomized controlled trial with a pre-post-test, quasi-experimental design was conducted.
    The study was conducted at two nursing schools from July to October 2023.
    Participants comprised nursing students holding bachelor\'s degrees in nursing, with three or four years of experience and successful completion of a neonatal nursing theory course. Additionally, individuals with at least six months of experience working in a neonatal ward or delivery room before enrolling in nursing school were eligible.
    The participants were divided into three groups: the VR group (n = 27) received contactless hand-tracking-based immersive VR neonatal Apgar scoring training; the simulation group (n = 28) received face-to-face Apgar scoring simulation training; and the control group (n = 26) received instruction on the Apgar scoring criteria. Changes in scores among the VR, simulation, and control groups were statistically compared using ANOVA with SPSS-WIN 27.0.
    The VR group exhibited significant improvements in knowledge, learning satisfaction, self-confidence, immersion, and motivation compared to the simulation and control groups. Moreover, satisfaction was significantly higher in the VR group than in the simulation group.
    The hand-tracking-based immersive VR neonatal Apgar scoring program represents an innovative and effective educational tool, prioritizing the privacy and rights of mothers and infants. It can potentially replace traditional delivery-room clinical training, which is observation-based and limited.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    背景:围产期窒息的负担在我们的环境中仍然很高,当窒息严重时,重要器官受到影响,导致心脏多器官缺氧缺氧性损伤,大脑,肾上腺和其他器官。
    目的:应用血清心肌肌钙蛋白I(cTnI)评价窒息足月新生儿缺氧缺血性脑病的心肌损伤。
    方法:该研究是一项基于医院的描述性横断面研究,涉及60例足月窒息新生儿和60例胎龄和性别匹配的对照。受试者为5分钟Apgar评分≤6和HIE的足月新生儿,而对照组为5分钟Apgar评分>6的健康足月新生儿。五分钟的Apgar评分用于将窒息分为轻度,中度和重度窒息。通过改良的Sarnat和Sarnat标准确定脑病的程度。使用酶联免疫吸附测定技术在生命的12-24小时测量受试者和对照的血清cTnI。还测量了参与者的血清胆红素水平以排除高胆红素血症。
    结果:受试者的中位血清cTnI水平(0.56ng/mL;0.25-0.94ng/mL)明显高于对照组(0.50ng/mL;0.00-0.67ng/mL),分别为p=0.001。同样,HIEII期(0.56ng/mL;0.38~0.72ng/mL)或III期(0.56ng/mL;0.50~0.94ng/mL)的血清cTnI中位数水平也显著高于HIEI期(0.38ng/mL;0.25~0.72ng/mL)或对照组(0.50ng/mL;0.00~0.67ng/mL)的中位数;p<0.001.窒息新生儿血清cTnI水平与HIE严重程度呈正相关(rs=0.505,p<0.001)。
    结论:重度窒息HIE新生儿血清cTnI水平升高。血清cTnI浓度与HIE严重程度呈正相关。因此,窒息新生儿中HIE的存在应提示使用血清cTnI评估心肌损伤.注意到的任何紊乱都应建立心血管支持,以改善预后并降低窒息相关死亡率。
    BACKGROUND: The burden of perinatal asphyxia remains high in our environment and when asphyxia is severe, vital organs are affected, with resultant multiorgan hypoxic-iscahemic injury to the heart, the brain, adrenals and other organs.
    OBJECTIVE: To evaluate for myocardial injury in asphyxiated term neonates with hypoxic ischaemic encephalopathy using serum cardiac troponin-I (cTnI).
    METHODS: The study was a hospital-based descriptive cross-sectional study involving sixty term asphyxiated neonates and sixty gestational age-and sex-matched controls. The subjects were term neonates with five-minute Apgar score ≤ 6 and HIE while the controls were healthy term neonates with five-minute Apgar score > 6. Five-minute Apgar score was utilized to classify asphyxia into mild, moderate and severe asphyxia. The degree of encephalopathy was determined by modified Sarnat and Sarnat criteria. The serum cTnI was measured in subjects and controls at 12-24 hours of life using Enzyme-linked immunosorbent assay technique. The serum bilirubin levels were also measured in participants to exclude hyperbilirubinemia.
    RESULTS: The median serum cTnI levels was significantly higher in the subjects (0.56ng/mL; 0.25-0.94ng/mL) than in the controls (0.50ng/mL; 0.00-0.67ng/mL), respectively; p=0.001. Similarly, the median serum cTnI level in HIE stage II (0.56ng/mL; 0.38-0.72ng/mL) or III (0.56ng/ml; 0.50-0.94ng/mL) was also significantly higher than the median value in HIE stage I (0.38ng/mL;0.25-0.72ng/mL) or in controls (0.50ng/mL; 0.00-0.67ng/mL); p<0.001. There was significant positive correlation between serum cTnI levels and severity of HIE in asphyxiated neonates (rs = 0.505, p < 0.001).
    CONCLUSIONS: serum cTnI levels were elevated in severely asphyxiated neonates with HIE. The concentration of serum cTnI demonstrated significant positive correlation with HIE severity. Hence, the presence of HIE in asphyxiated neonates should prompt an evaluation for myocardial injury using serum cTnI. Any derangement noted should warrant instituting cardiovascular support in order to improve outcome and reduce asphyxia-related mortality.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    通过一种新的高血压分类方法,分析胎盘早剥(PA)对母婴的影响。除高血压外,还比较了初始血红蛋白参数以预测妊娠结局。这项回顾性队列设计研究是对115名患有PA的孕妇进行的。从医院数据库和患者医疗文件中扫描并记录主要参数。两组根据是否存在高血压进行分类(53高血压,62血压正常)。产妇的人口统计学和临床特征(腹痛,记录阴道出血)。APGAR在第1分钟和第5分钟得分低于5分,胎儿或新生儿死亡,还调查了新生儿重症监护病房的入院时间和住院时间,并在两组之间进行了比较。第5分钟时,高血压组的死胎与活产比率和较低的APGAR评分<5明显高于血压正常组(分别为P=.006和0.047)。在输血率方面,高血压组的产妇结局较差,高于血压正常组(27/53,50.9%;18/62,29%,分别,P=.017)。在有HT的PA中,腹痛较多,阴道出血较少。较高的淋巴细胞计数,平均血小板体积,报告了高血压组的血小板分布宽度。检测到患有PA的高血压患者的母婴结局较差。这些患者应该得到更多的关注,不仅要评估与早剥相关的可能风险,还要评估伴随的并发症。
    To analyze maternal and neonatal effects of placental abruption (PA) through a novel classification in the presence of hypertension. Initial hemoglobin parameters were also compared to predict pregnancy outcomes in addition to hypertension. This retrospective cohort designed study was conducted on 115 pregnant women with PA. The main parameters scanned and recorded from the hospital database and patient medical files. Two groups were classified regarding of presence or absence of hypertension (53 hypertensive, 62 normotensive). Maternal demographical and clinical characteristics (abdominal pain, vaginal bleeding) were recorded. APGAR scores below 5 at 1st and 5th minute, fetal or neonatal death, admission and length of stay in Neonatal Intensive Care Unit were also investigated and compared between the groups. Stillborn to live-born ratio and lower APGAR scores < 5 at 5th minute were significantly higher in hypertensive group than normotensive group (P = .006 and 0.047, respectively). Poor maternal outcomes were detected in the hypertensive group than normotensive group regarding rate of blood transfusion (27/53, 50.9%; 18/62, 29%, respectively, P = .017). More abdominal pain and less vaginal bleeding were seen in PA with HT. Higher lymphocyte count, mean platelet volume, and platelet distribution width were reported in hypertensive group. Poorer maternal and neonatal outcomes of hypertensive patients with PA were detected. These patients should deserve greater attention to assess not only the possible risks associated with abruption but also the accompanying complications.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

公众号