目的:在撒哈拉以南非洲地区,主动脉根部重塑对左心室影响的研究很少,尽管该地区的动脉高血压患病率很高,这与Valsalva直径的鼻窦呈正相关。本工作旨在确定近端主动脉根部扩大的频率,并分别评估其与刚果患者左心室结构和功能的关系。
方法:招募了四百三(403)名实现经胸心脏回波描记术的患者。使用逐步方法在多元线性回归中对近端主动脉根直径与左心室超声心动图参数之间的关联进行建模。
结果:在403名患者中,69.4%为高血压。多元线性回归分析显示主动脉近端根径与左心室质量相关(β=1.12;P=0.01),左室舒张内径(β=0.26,P=0.001)和E/A比值(β=-0.02,P<0.0001)。主动脉近端根径的独立预测因素为年龄(β=0.06,P=0.0006),动脉高血压持续时间(β=0.11,P=0.002)和舒张压(β=0.03;P=0.02)。近端主动脉根扩张的频率为3.5%。
结论:这些结果证实了将近端主动脉根扩张作为刚果人特定的临床危险因素的重要性。
OBJECTIVE: Studies of the influence of aortic root remodelling on the left ventricle are scarce in sub Saharan Africa even though this region has got high prevalence of arterial hypertension which is positively related to sinuses of Valsalva diameter. The present work aims to determine the frequency of the proximal aortic root enlargement and to evaluate its association with the left ventricle structure and function respectively among Congolese patients.
METHODS: Four hundreds and three (403) patients who realised transthoracic cardiac echography were recruited. The association between the proximal aortic root diameter and the left ventricular echocardiographic parameters was modelised in a multiple linear regression using the Stepwise method.
RESULTS: Among the 403 patients, 69.4% were hypertensive. A multivariate linear regression analysis showed correlations between the proximal aortic root diameter and the left ventricular mass (β=1.12; P=0.01), the left ventricular diastolic diameter (β=0.26, P=0.001) and the E/A ratio (β=-0.02; P<0.0001) respectively. The independent predictor of the proximal aortic root diameter were age (β=0.06, P=0.0006), duration of arterial hypertension (β=0.11, P=0.002) and diastolic blood pressure (β=0.03; P=0.02). The frequency of the proximal aortic root dilatation was 3.5%.
CONCLUSIONS: These results infancies the importance of including the proximal aortic root dilatation as specific infra clinic risk factor among Congolese.