目的:6分钟步行测试(6MWT)是一种简单的测试,广泛用于评估慢性呼吸系统疾病的亚最大运动能力。我们探索了6分钟步行距离(6MWD)与生理测量的关系,临床,肌炎相关间质性肺病(MA-ILD)患者的影像学检查。
方法:我们分析了Abatacept在肌炎相关间质性肺病(AttackMy-ILD)研究中的数据,一项针对抗合成酶抗体和活性MA-ILD患者的为期48周的多中心随机试验。6MWD,强迫肺活量(FVC),扩散能力(DLCO),高分辨率CT,试验期间获得了各种医师/患者报告的结局指标.使用Spearman的相关性和线性混合效应模型的重复测量分析来估计6MWD与各种生理之间的关联,横向和纵向的临床和影像学参数。
结果:分析了20名平均年龄为57岁的参与者,其中55%为男性,85%为白人。基线6MWD与基线PFT无关。重复测量分析显示,随着时间的推移,6MWD与FVC相关,但不是DLCO。随着时间的推移,6MWD也与UCSD呼吸困难评分相关,博格得分,以及随着时间的推移全球疾病活动和肌肉力量。情感角色功能,活力,短表36的一般健康和身体功能评分也与6MWD相关。
结论::在一小组MA-ILD中进行的探索性研究表明,随着时间的推移,6MWD与FVC的平行变化以及患者报告的呼吸困难结局相关,但不是DLCO。需要更大的研究来验证可靠性,MA-ILD中6MWT的响应性和实用性。
背景:ClinicalTrials.gov,NCT03215927。
OBJECTIVE: The 6-min walk test (6MWT) is a simple test widely used to assess sub-maximal exercise capacity in chronic respiratory diseases. We explored the relationship of 6-min walk distance (6MWD) with measurements of physiological, clinical, radiographic measures in patients with myositis-associated interstitial lung disease (MA-ILD).
METHODS: We analyzed data from the Abatacept in Myositis Associated Interstitial lung disease (Attack My-ILD) study, a 48-week multicentre randomized trial of patients with anti-synthetase antibodies and active MA-ILD. 6MWD, forced vital capacity (FVC), diffusing capacity (DLCO), high resolution CT, and various physician/patient reported outcome measures were obtained during the trial. Spearman\'s correlations and repeated-measures analysis with linear mixed-effects models were used to estimate the associations between 6MWD and various physiologic, clinical and radiographic parameters both cross-sectionally and longitudinally.
RESULTS: Twenty participants with a median age of 57, 55% male and 85% white were analyzed. Baseline 6MWD did not associate with baseline PFTs. Repeated-measures analysis showed 6MWD over time associated with FVC over time, but not with DLCO. 6MWD over time also correlated with UCSD dyspnea score, Borg scores, as well as global disease activity and muscle strength over time. Emotional role functioning, vitality, general health and physical functioning scores by short form 36 also correlated with 6MWD over time.
CONCLUSIONS: : Exploratory work in a small cohort of MA-ILD demonstrated 6MWD over time associated with parallel changes in FVC and patient reported outcomes of dyspnea, but not with DLCO. Larger studies are needed to validate the reliability, responsiveness and utility of the 6MWT in MA-ILD.
BACKGROUND: ClinicalTrials.gov, NCT03215927.