目的:比较类风湿关节炎(RA)患者和代谢紊乱(MD)患者接种疫苗后的抗体反应。该研究特别强调了解在现实环境中常见疾病如何影响RA患者的抗体反应。
方法:参与者是117例RA患者(66例仅RA患者,51例RA和MD患者)和37例MD患者,他们接受了主要系列疫苗接种和加强疫苗接种。在初次接种疫苗和加强疫苗后,比较了抗体滴度,并评估了影响抗体反应的因素。
结果:在主要的一系列疫苗接种之后,在疫苗接种和抗体测量之间的天数较长的患者中观察到抗体滴度显着降低,使用IL-6抑制剂,选择性T细胞共刺激调节剂,和甲氨蝶呤.共病MD对RA的抗体反应没有显着影响。值得注意的是,在多元线性回归分析中,RA本身的存在并不显著.服用助推器后,然而,在疫苗接种和抗体测量之间的一天,使用IL-6抑制剂,和甲氨蝶呤不再保持显著。只有选择性T细胞共刺激调节剂的使用保留了其重要性。
结论:MD对RA患者的抗体应答没有显著影响。在RA患者中的主要系列之后的降低的抗体应答似乎更多地归因于特定的RA药物而不是疾病本身。加强疫苗对于恢复RA的抗体反应至关重要。
OBJECTIVE: To compare antibody responses after vaccinations between patients with rheumatoid arthritis (RA) and patients with metabolic disorders (MD). The study places special emphasis on understanding how common diseases affect antibody responses in individuals with RA within real-world settings.
METHODS: The participants were 117 patients with RA (66 with RA only and 51 with RA and MD) and 37 patients with MD who received both the primary series of vaccinations and a booster. Antibody titers were compared after the primary series of vaccinations and a booster, and factors influencing the antibody response were assessed.
RESULTS: Following the primary series of vaccinations, a significant reduction in antibody titers was observed in patients with longer days between vaccination and antibody measurement, the use of IL-6 inhibitors, selective T cell co-stimulation modulators, and methotrexate. Comorbid MD did not exhibit significant influences on antibody response in RA. Notably, the presence of RA itself was not significant in multivariate linear regression analysis. After the administration of the booster, however, day between vaccination and antibody measurement, the use of IL-6 inhibitor, and methotrexate no longer remained significant. Only the use of selective T cell co-stimulation modulators retained its significance.
CONCLUSIONS: MD did not exhibit a significant impact on antibody responses in RA patients. The reduced antibody response following the primary series in RA patients appeared to be attributed more to specific RA medications rather than to the disease itself. Booster vaccines are vital in restoring the antibody response in RA.