■在横断面研究中,黄曲霉毒素(AF)暴露与儿童生长步履蹒跚有关,纵向研究的发现有限。
■为了评估母体AFB1-赖氨酸加合物浓度之间的关系,子AFB1-赖氨酸加合物浓度,和孩子在生命的前30个月成长。
■使用同位素稀释质谱法在母婴二元血浆样品中测量AFB1-赖氨酸加合物。使用线性回归,我们评估了AFB1-赖氨酸加合物浓度与儿童体重之间的关系,高度,1周时的头部和中上臂圆周,6、12、18、24和30个月的年龄。
■在调整后的模型中,母体产前AFB1-赖氨酸加合物(pg/μL)与新生儿人体测量结果呈正相关;标准化值之间关联的最大β系数为新生儿体重年龄z评分[β=0.13;95%置信区间(CI):0.02,0.24;P<0.05和β=0.11;95%CI:0.00,0.22;妊娠中期和晚期AF的P<0.05,分别]。儿童AFB1-赖氨酸加合物(pg/μL)在6、18、24和30个月与头围年龄z评分呈负相关,β系数范围为β=-0.15;95%CI:-0.28,-0.02至β=-0.17;95%CI:-0.31,-0.03;P<0.05);18个月AF与18、24和30个月的人体测量学结果呈负相关,与年龄z评分最一致(β=-0.18;95%CI:-0.32,-0.04,β=-0.21;95%CI:-0.35,-0.07,β=-0.18;95%CI:-0.32,-0.03,在18、24和30个月,分别)。
■儿童房颤暴露与儿童生长受损有关,但母体房颤暴露没有。婴儿期暴露与头围持续不足有关,这意味着持续超过2岁的大脑尺寸减小。18个月的暴露与持续的线性生长不足有关。进一步的研究应阐明AF影响儿童成长的机制。
UNASSIGNED: Aflatoxin (AF) exposure is associated with child growth faltering in cross-sectional studies, with limited findings from longitudinal studies.
UNASSIGNED: To evaluate the relationship between maternal AF B1-lysine adduct concentration, child AF B1-lysine adduct concentration, and child growth in the first 30 mo of life.
UNASSIGNED: AF B1-lysine adduct was measured in mother-child dyad plasma samples using isotope dilution mass spectrometry. Using linear regression, we assessed the relationship between AF B1-lysine adduct concentration and child weight, height, and head and mid-upper arm circumferences at 1 wk, 6, 12, 18, 24, and 30 mo of age.
UNASSIGNED: In adjusted models, maternal prenatal AF B1-lysine adduct (pg/μL) was positively associated with newborn anthropometric outcomes; largest beta coefficients for associations between standardized values were for newborn weight-for-age z-score [β = 0.13; 95% confidence interval (CI): 0.02, 0.24; P < 0.05 and β = 0.11; 95% CI: 0.00, 0.22; P < 0.05 for second and third trimester AF, respectively]. Child AF B1-lysine adduct (pg/μL) at 6 mo was negatively associated with head circumference-for-age z-score at 6, 18, 24, and 30 mo, with beta coefficients ranging from β = -0.15; 95% CI: -0.28, -0.02 to β = -0.17; 95% CI: -0.31, -0.03; P < 0.05); 18-mo AF was negatively associated with anthropometric outcomes at 18, 24, and 30 mo, most consistently with length-for-age z-score (β = -0.18; 95% CI: -0.32, -0.04, β = -0.21; 95% CI: -0.35, -0.07, β = -0.18; 95% CI: -0.32, -0.03 at 18, 24 and 30 mo, respectively).
UNASSIGNED: Child AF exposure was associated with impaired child growth, but maternal AF exposure was not. Exposure during infancy was linked to persistent deficit in head circumference, implying reduced brain size lasting beyond the age of 2 years. Exposure at 18 mo was linked to persistent linear growth deficit. Further research should elucidate mechanisms through which AF affects child growth.