钛和钛合金具有低密度和接近自然骨的弹性模量的优点,可以降低应力屏蔽效应,成为人体硬组织置换和修复的首选方法之一。然而,植入部位感染仍是植入失败的主要原因之一。在本文中,将2.5wt%Ag元素添加到Ti-15Mo中以获得低模量,并应用表面阳极氧化来提高表面生物相容性。弹性模量,微观形态,表面元素化合价,耐腐蚀性,抗菌性能,和细胞相容性通过机械测试进行研究,扫描电子显微镜,X射线光电子能谱,电化学测试,电感耦合等离子体光谱,平板计数法,和细胞测试。实验结果表明,阳极氧化的Ti-15Mo-2.5Ag样品的弹性模量为79GPa,具有很强的耐腐蚀性,强抗菌能力≥99.99%,和良好的生物相容性。结果表明,Ag2O在表面的形成和Ag离子的释放提高了抗菌性能,银离子与微米和纳米结构的结构协同作用在促进细胞早期扩散和提高细胞相容性方面发挥了重要作用。
Titanium and titanium alloys have the advantages of a low density and a close elastic modulus to natural bone, which can reduce the stress-shielding effect and become one of the first choices for human hard tissue replacement and repair. However, implant site infection is still one of the main reasons for implantation failure. In this paper, 2.5 wt % Ag element was added to Ti-15Mo to obtain a low modulus, and a surface
anodization was applied to improve the surface biocompatibility. The elastic modulus, micromorphology, surface elemental valence, corrosion resistance, antimicrobial properties, and cytocompatibility were investigated by mechanical tests, scanning electron microscopy, X-ray photoelectron spectroscopy, electrochemical tests, inductively coupled plasma spectroscopy, plate counting method, and cellular tests. The experimental results showed that the anodized Ti-15Mo-2.5Ag sample exhibited an elastic modulus of 79 GPa, a strong corrosion resistance, a strong antimicrobial ability of ≥99.99%, and good biocompatibility. It was demonstrated that the formation of Ag2O on the surface and Ag ion release improved the antimicrobial properties and that the structural synergism of silver ions with micro- and nanostructures played an important role in promoting the early spreading of cells and improving the cytocompatibility.