■这项研究旨在评估身体质量指数(BMI)与肛门高危型人乳头瘤病毒(HR-HPV)和活检证实的组织学肛门高度鳞状上皮内病变(HSIL)之间的关系在波多黎各的基于临床的西班牙裔样本中。
这项横断面研究评估了2014年10月至2022年12月在波多黎各大学综合癌症中心肛门肿瘤诊所接受服务的成年人的医疗记录。该研究包括543条记录,其中包含有关肛门HR-HPV和肛门HSIL状态的完整临床信息。进行卡方和逻辑回归分析。
■参与者的平均年龄为44.10±13.24岁,65.2%是男性,71.7%的人感染了艾滋病毒,74.4%有肛门HR-HPV感染,37.9%的患者有活检证实的HSIL。关于BMI,2.4%体重不足,31.9%正常体重,超重39.0%;17.3%的人有一级,5.2%II类,和4.2%的III类肥胖。在调整后的分析中,BMI与肛门HR-HPV感染之间未观察到显着关联。与体重不足/正常的成年人相比,超重个体(OR:0.63,95%CI:0.41-0.99)和II/III类肥胖个体(OR:0.48,95%CI:0.22-1.01)的肛门HSIL几率较低。在调整了潜在的混杂因素后。未观察到I类肥胖的显著关联。
■BMI与肛门HR-HPV感染无关。超重和肥胖个体患肛门HSIL的几率低于体重不足/正常BMI的成年人。这一发现可能表明超重/肥胖个体中HSIL的诊断不足,或降低该组的风险。
UNASSIGNED: This study aimed to assess the association of body mass index (BMI) with anal high-risk human papillomavirus (HR-HPV) and biopsy-confirmed histologic anal high-grade squamous intraepithelial lesions (HSIL) among a clinic-based sample of Hispanics in Puerto Rico.
UNASSIGNED: This cross-sectional study evaluated medical records of adults who received services at the Anal Neoplasia Clinic of the University of Puerto Rico Comprehensive Cancer Center between October 2014 and December 2022. The study included 543 records with complete clinical information regarding anal HR-HPV and anal HSIL status. Chi-square and logistic regression analyses were performed.
UNASSIGNED: Mean age of participants was 44.10 ± 13.24 years, 65.2% were men, 71.7% were HIV-infected, 74.4% had anal HR-HPV infection, and 37.9% had biopsy-confirmed HSIL. Regarding BMI, 2.4% were underweight, 31.9% normal weight, and 39.0 % overweight; while 17.3 % had class I, 5.2% class II, and 4.2% class III obesity. No significant association was observed between BMI and anal HR-HPV infection in adjusted analyses. Lower odds of anal HSIL were observed among overweight individuals (OR: 0.63, 95% CI: 0.41 - 0.99) and those with class II/III obesity (OR: 0.48, 95% CI: 0.22 - 1.01) compared to adults with underweight/normal BMI, after adjusting for potential confounders. No significant association was observed for class I obesity.
UNASSIGNED: BMI was not associated with anal HR-HPV infection. Overweight and obese individuals had lower odds of having anal HSIL than adults with underweight/normal BMI. This finding could suggest underdiagnosis of HSIL among overweight/obese individuals, or reduced risk in this group.