背景:淀粉样变以细胞外淀粉样蛋白沉积为特征。当淀粉样变性与基底细胞癌(BCC)相交时,它引入了复杂的诊断挑战。本研究探讨了原发性局限性皮肤淀粉样变性(PLCA)和BCC之间的重叠,检查BCC中的淀粉样蛋白沉积物,PLCA的系统性淀粉样变性风险,和各种治疗方法。
方法:讨论了两个案例研究,随后是文献综述,其中PubMed,WebofScience,EMBASE,并利用了Cochrane图书馆数据库。搜索,涵盖从无限到2024年1月的研究,重点是皮肤淀粉样变性,基底细胞癌,”和相关术语。详细介绍临床表现的英文文章,诊断方法,治疗,包括模拟BCC的皮肤淀粉样变性的结果。数据提取和合成由两名独立的审阅者进行。
方法:本研究强调了两个病例,证明了诊断BCC和PLCA的复杂性。第一例(64岁,脸颊上有结节)和第二例(67岁,上唇脸颊上有结节性病变)最初被怀疑为BCC,后来在组织病理学检查中被确定为PLCA。
结论:BCC结节内淀粉样变性的诊断仍然是一个诊断挑战。尽管它们的共存相对普遍,他们的局部复发率仍有争议。已经提出了各种诊断和治疗方法,如局部面霜和光疗。然而,没有一个获得了确凿和一致的证据来建立可靠的临床应用。
结论:研究结果强调了在鉴别诊断中考虑替代病理的重要性。未来的研究应该集中在了解系统性淀粉样变性风险和优化护理这两种情况。
BACKGROUND: Amyloidosis is characterized by extracellular amyloid protein deposition. When amyloidosis intersects with basal cell carcinoma (BCC), it introduces complex diagnostic challenges. This study explored the overlap between primary localized cutaneous amyloidosis (PLCA) and BCC, examining amyloid deposits in BCC, systemic amyloidosis risk in PLCA, and various treatment methods.
METHODS: Two case studies were discussed, followed by a literature review, in which PubMed, Web of Science, EMBASE, and the Cochrane Library databases were utilized. The search, covering studies from infinity up to January 2024, focused on \"cutaneous amyloidosis,\" \"basal cell carcinoma,\" and related terms. Articles in English detailing the clinical presentation, diagnostic methods, treatment, and outcomes of cutaneous amyloidosis mimicking BCC were included. Data extraction and synthesis were performed by two independent reviewers.
METHODS: This study highlighted two cases exemplifying the complexity of diagnosing BCC and PLCA. The first case (a 64-year-old with a nodule on the cheek) and the second (a 67-year-old with a nodular lesion on the upper lip cheek) were initially suspected as BCC and were later identified as PLCA upon histopathological examination.
CONCLUSIONS: The diagnosis of amyloidosis within BCC nodules remains a diagnostic challenge. Although their coexistence is relatively prevalent, their local recurrence rates remain debatable. Various diagnostic and therapeutic approaches have been suggested, such as topical creams and phototherapy. However, none have garnered conclusive and consistent evidence to establish reliable clinical application.
CONCLUSIONS: The findings emphasized the importance of considering alternative pathologies in differential diagnoses. Future research should focus on understanding systemic amyloidosis risks and optimizing care for both conditions.