背景:认知障碍(CI)阿尔茨海默病(AD)患者的脑血流量(CBF)减少。我们检查了时间编码动脉自旋标记(te-ASL)在测量具有阳性AD生物标志物的个体的CBF改变以及与认知未受损(CU)个体中相关生物标志物的关联中的敏感性。
方法:我们比较了te-ASL与单标签后延迟(PLD)ASL在测量AD连续体中59名成年人的CBF时,分类为CU淀粉样β(Aβ)阴性(-),CUAβ阳性(+),和CIAβ+。我们寻求CBF与AD生物标志物的关联,脑血管疾病,突触功能障碍,神经变性,和CU参与者的认知。
结果:te-ASL对检测CUAβ+和CIAβ+组的CBF降低更敏感。在CU参与者中,较低的CBF与Aβ生物标志物的改变有关,tau,突触功能障碍,和神经变性。
结论:CBF降低发生在AD的早期。te-ASL在检测AD的CBF变化方面比单PLDASL更敏感。
结论:在早期AD连续体中,CU受试者可检测到较低的CBF。te-ASL在检测AD的CBF改变方面比单一PLDASL更敏感。CBF与AD的生物标志物有关,突触功能障碍,和神经变性。
BACKGROUND: Cerebral blood flow (CBF) is reduced in cognitively impaired (CI) Alzheimer\'s disease (AD) patients. We checked the sensitivity of time-encoded arterial spin labeling (te-ASL) in measuring CBF alterations in individuals with positive AD biomarkers and associations with relevant biomarkers in cognitively unimpaired (CU) individuals.
METHODS: We compared te-ASL with single-postlabel delay (PLD) ASL in measuring CBF in 59 adults across the AD continuum, classified as CU amyloid beta (Aβ) negative (-), CU Aβ positive (+), and CI Aβ+. We sought associations of CBF with biomarkers of AD, cerebrovascular disease, synaptic dysfunction, neurodegeneration, and cognition in CU participants.
RESULTS: te-ASL was more sensitive at detecting CBF reduction in the CU Aβ+ and CI Aβ+ groups. In CU participants, lower CBF was associated with altered biomarkers of Aβ, tau, synaptic dysfunction, and neurodegeneration.
CONCLUSIONS: CBF reduction occurs early in the AD continuum. te-ASL is more sensitive than single-PLD ASL at detecting CBF changes in AD.
CONCLUSIONS: Lower CBF can be detected in CU subjects in the early AD continuum. te-ASL is more sensitive than single-PLD ASL at detecting CBF alterations in AD. CBF is linked to biomarkers of AD, synaptic dysfunction, and neurodegeneration.