背景和目的:由于心血管原因导致的死亡率和发病率在截肢者中经常经历。关于慢性运动对这些个体的生物标志物和心脏损伤指标的影响的研究是有限的。这项研究的目的是研究核心训练计划对脑利钠相关肽的影响,以及截肢足球运动员的血液学和生化参数。材料和方法:将参与者随机分为以下两组:核心运动组(CEG)和对照组(CG)。当CG继续例行足球训练时,CEG组被纳入与该组不同的核心锻炼计划.在研究期间,参与者的常规血象参数,各种生化标记,分析脑钠素相关肽(NT-pro-BNP)浓度。结果:培训期结束后,两组的各种血液学参数均有显著改善.在CEG中,红细胞计数(RBC)显着增强,血细胞比容(HCT),平均红细胞血红蛋白浓度(MCHC),和平均红细胞血红蛋白(MCH)值。同样,CG也显示红细胞大幅改善,HCT,平均红细胞体积(MCV),MCHC,MCH,红细胞分布宽度-标准偏差(RDW-SD),血小板与淋巴细胞比率(PLCR),平均血小板体积(MPV),和血小板分布宽度(PDW)。此外,在CEG中,血清甘油三酯(TG)和最大摄氧量(MaxVO2)显着增加。相反,CG中TG水平下降,而高密度脂蛋白(HDL),低密度脂蛋白(LDL),和MaxVO2水平显示大幅升高。值得注意的是,核心运动计划后,CEG或CG的N末端脑钠肽前体(BNP)水平均无显著变化(p>0.05).然而,在CEG中,核心运动项目前后NT-pro-BNP与肌酸激酶(CK)水平呈有意义的正相关.结论:研究结果强调了核心训练在增强特定生理方面的潜在益处,如红细胞相关参数和脂质代谢,以及有氧能力。此外,观察到的CEG中NT-pro-BNP和CK水平之间的相关性为截肢运动员独特的生理适应提供了有趣的见解。
Background and Objectives: mortality and morbidity due to cardiovascular causes are frequently experienced in
amputees. Research on the effects of chronic exercise on biomarkers and cardiac damage indicators in these individuals is limited. The aim of this study was to investigate the effects of a core training program on brain natriuretic-related peptide, as well as hematological and biochemical parameters in amputee soccer players. Materials and Methods: The participants were randomly allocated to the following two groups: a core exercise group (CEG) and a control group (CG). While the CG continued routine soccer training, the CEG group was included in a core exercise program different from this group. During the study, routine hemogram parameters of the participants, various biochemical markers, and the concentration of brain natriuretic-related peptide (NT-pro-BNP) were analyzed. Results: after the training period, notable improvements in various hematological parameters were observed in both groups. In the CEG, there were significant enhancements in red blood cell count (RBC), hematocrit (HCT), mean corpuscular hemoglobin concentration (MCHC), and mean corpuscular hemoglobin (MCH) values. Similarly, the CG also showed substantial improvements in RBC, HCT, mean corpuscular volume (MCV), MCHC, MCH, red cell distribution width-standard deviation (RDW-SD), platelet-to-lymphocyte ratio (PLCR), mean platelet volume (MPV), and platelet distribution width (PDW). Moreover, in the CEG, serum triglycerides (TG) and maximal oxygen uptake (MaxVO2) exhibited significant increases. Conversely, TG levels decreased in the CG, while high-density lipoprotein (HDL), low-density lipoprotein (LDL), and MaxVO2 levels demonstrated substantial elevations. Notably, the N-terminal pro-brain natriuretic peptide (BNP) levels did not undergo significant changes in either the CEG or the CG following the core exercise program (p > 0.05). However, in the CEG, a meaningful positive correlation was observed between NT-pro-BNP and creatine kinase (CK) levels before and after the core exercise program. Conclusions: the findings emphasized the potential benefits of core training in enhancing specific physiological aspects, such as erythrocyte-related parameters and lipid metabolism, as well as aerobic capacity. Furthermore, the observed correlation between NT-pro-BNP and CK levels in the CEG provides intriguing insights into the unique physiological adaptations of amputee athletes.