■这项研究的目的是研究一般美国人群中睡眠持续时间与肌肉减少症风险之间的关系。
■利用2011年至2014年国家健康和营养检查调查的公开数据,我们探讨了睡眠时间与肌肉减少症患病率之间的关系。为了调查他们的关系,我们进行了加权多元逻辑回归分析,限制三次样条(RCS)曲线,和亚组分析。
■该研究包括8200名个体,其中99人(0.9%)患有肌少症。RCS曲线显示肌肉减少症与睡眠持续时间呈U形关联(非线性P=0.020),表明肌肉减少症的风险随着睡眠时间的增加而降低,在6.67小时左右达到最低风险。在控制潜在的联合创始人之后,与睡眠持续时间<5小时的个体相比,肌肉减少症95%置信区间的比值比为0.64(0.27,1.49),0.50(0.20,1.26),0.65(0.27,1.60),<5-6、6.5-7.5、8-9和>9h组分别为2.31(0.73、7.30)。在年龄<40岁或≥40岁的受试者中也观察到睡眠时间与肌肉减少症患病率之间的U形关联。是男性还是女性,有或没有高血压,和糖尿病。
■总之,短睡眠时间和长睡眠时间都会增加肌肉减少症的患病率.需要进一步的研究来探索潜在的机制。
UNASSIGNED: The purpose of this study was to examine the relationship between sleep duration and risk of sarcopenia in in general U.S. population.
UNASSIGNED: Utilizing publicly available data from the National Health and Nutrition Examination Survey spanning from 2011 to 2014, we explored the association between sleep duration and prevalence of sarcopenia. To investigate their relationship, we conducted weighted multivariate logistic regression analysis, restricted cubic splines (RCS) curve, and subgroup analysis.
UNASSIGNED: The study included 8,200 individuals, among whom 99 (0.9 %) had sarcopenia. The RCS curve revealed a U-shaped association of sarcopenia with sleep duration (P for nonlinearity = 0.020), showing that the risk of sarcopenia decreases with increasing sleep duration, reaching the lowest risk around 6.67 h. After controlling for underlying cofounders, compared to individuals with sleep duration < 5 h, the odds ratios with 95 % confidence intervals of sarcopenia were 0.64 (0.27, 1.49), 0.50 (0.20, 1.26), 0.65 (0.27, 1.60), and 2.31 (0.73, 7.30) for < 5-6, 6.5-7.5, 8-9, and > 9 h group. The U-shaped association between sleep time and prevalence of sarcopenia also was observed in the subjects who aged < 40 or ≥ 40 years, were male or female, with or without hypertension, and diabetes mellitus.
UNASSIGNED: In summary, both short and long sleep durations increased prevalence of sarcopenia. Further studies are needed to explore the underlying mechanisms.