癌症生长是由参与细胞增殖的遗传和表观遗传修饰引发的分子机制。分化,凋亡,和衰老途径。化学预防是导致阻断的癌症治疗的重要策略,倒车,或者阻碍肿瘤发生的多步骤过程,包括其重要的形态发生里程碑的阻塞。正常,肿瘤前,瘤形成,和转移。由于许多原因,与合成药物相比,天然存在的植物化学物质变得越来越受欢迎。包括安全,生物利用度,功效,和容易的可用性。异硫氰酸烯丙酯(AITC)是十字花科所有植物中存在的天然化合物,比如抱子甘蓝,花椰菜,芥末,卷心菜,卷心菜羽衣甘蓝,辣根,还有芥末.几十年来进行的体外和体内研究表明,AITC抑制肿瘤发生,没有任何毒性和不良副作用。AITC的生物利用度非常高,据报道,近90%的口服AITC被吸收。AITC表现出多种药理学性质,其中其抗癌活性对于癌症治疗是最显著的。其抗癌活性是通过选择性调节与氧化应激相关的多种细胞信号通路发挥的,炎症,细胞增殖,细胞周期停滞,凋亡,血管生成,入侵,和转移。这篇综述强调了与(i)抑制致癌活化和诱导抗氧化剂相关的AITC抗癌作用有关的分子靶标的最新知识,(ii)抑制促炎和细胞增殖信号,(iii)诱导细胞周期停滞和凋亡,和(iv)抑制与转移相关的血管生成和侵袭性信号。
Cancer growth is a molecular mechanism initiated by genetic and epigenetic modifications that are involved in cell proliferation, differentiation, apoptosis, and senescence pathways. Chemoprevention is an important strategy for cancer treatment that leads to blocking, reversing, or impeding the multistep process of tumorigenesis, including the blockage of its vital morphogenetic milestones viz. normal, preneoplasia, neoplasia, and metastasis. Naturally occurring phytochemicals are becoming ever more popular compared to synthetic drugs for many reasons, including safety, bioavailability, efficacy, and easy availability. Allyl isothiocyanate (AITC) is a natural compound present in all plants of the Cruciferae family, such as Brussels sprouts, cauliflower, mustard, cabbage, kale, horseradish, and wasabi. In vitro and in vivo studies carried out over the decades have revealed that AITC inhibits tumorigenesis without any toxicity and undesirable side effects. The bioavailability of AITC is exceedingly high, as it was reported that nearly 90% of orally administered AITC is absorbed. AITC exhibits multiple pharmacological properties among which its anticancer activity is the most significant for cancer treatment. Its anticancer activity is exerted via selective modulation of multiple cell signaling pathways related to oxidative stress, inflammation, cell proliferation, cell cycle arrest, apoptosis, angiogenesis, invasion, and metastasis. This review highlights the current knowledge on molecular targets that are involved in the anticancer effect of AITC associated with (i) inhibition of carcinogenic activation and induction of antioxidants, (ii) suppression of pro-inflammatory and cell proliferative signals, (iii) induction of cell cycle arrest and apoptosis, and (iv) inhibition of angiogenic and invasive signals related to metastasis.