背景:两种疾病严重程度指数的效用,过敏性支气管肺曲霉病(ABPA)的支气管扩张严重程度指数(BSI)和FACED评分仍未知。目的:将BSI和FACED评分与免疫学参数(血清IgE[总量和烟曲霉特异性],A.烟曲霉特异性IgG,血液嗜酸性粒细胞计数),在ABPA的胸部计算机断层扫描和高衰减粘液。次要目标是评估BSI和FACED评分之间的相关性,并将BSI/FACED评分与支气管扩张健康问卷(BHQ)和圣乔治呼吸问卷(SGRQ)相关联。方法:我们在一项前瞻性观察性研究中纳入了患有支气管扩张症的初治ABPA受试者。我们在开始治疗前计算了每个受试者的BSI和FACED评分。受试者还完成了两份生活质量问卷(BHQ和SGRQ)。结果:我们纳入了91名受试者。平均(标准偏差)BSI和FACED评分为3.43(3.39)和1.43(1.27)。我们发现BSI或FACED与任何免疫学参数或高衰减粘液之间没有相关性。BSI和FACED评分之间有很强的相关性(r=0.76,p<0.001)。我们发现BSI和BHQ/SGRQ与FACED和SGRQ之间存在弱相关性。结论:我们发现BSI和FACED与ABPA的免疫学参数之间没有相关性。然而,我们发现BSI和FACED之间存在显著相关性,SGRQ和BHQ之间存在弱相关性。ABPA可能需要单独的疾病严重程度评分系统。
UNASSIGNED: The utility of two disease-severity indices, namely bronchiectasis severity index (BSI) and FACED score in allergic bronchopulmonary aspergillosis (ABPA) remains unknown.
UNASSIGNED: To correlate the BSI and FACED scores with immunological parameters (serum IgE [total and A. fumigatus-specific], A. fumigatus-specific IgG, blood eosinophil count), and high-attenuation mucus on chest computed tomography in ABPA. The secondary objectives were to evaluate the correlation between BSI and FACED scores and correlate the BSI/FACED scores with the bronchiectasis health questionnaire (BHQ) and Saint George\'s Respiratory Questionnaire (SGRQ).
UNASSIGNED: We included treatment-naïve ABPA subjects with bronchiectasis in a prospective observational study. We computed the BSI and FACED scores for each subject before initiating treatment. The subjects also completed two quality-of-life questionnaires (BHQ and SGRQ).
UNASSIGNED: We included 91 subjects. The mean (standard deviation) BSI and FACED scores were 3.43 (3.39) and 1.43 (1.27). We found no correlation between BSI or FACED with any immunological parameter or high-attenuation mucus. There was a strong correlation between BSI and FACED scores (r = 0.76, p < 0.001). We found a weak correlation between BSI and BHQ/SGRQ and FACED and SGRQ.
UNASSIGNED: We found no correlation between BSI and FACED with immunological parameters in ABPA. However, we found a significant correlation between BSI and FACED and a weak correlation between SGRQ and BHQ. ABPA likely requires a separate disease-severity scoring system.