Aide médicale à la procréation

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  • 文章类型: English Abstract
    背景:根据2022年提交给法国卫生部长的《国家反不育战略报告》,其目标13是:更好地识别和诊断男性不育,我们想与生殖专家澄清泌尿科医生在不育夫妇的管理中应该扮演什么角色。
    方法:与生殖医学和生物学-男科横向专业培训的教学委员会和飞行员达成了专家共识,和总统们一起,法国生殖研究联合会(FFER)的董事会和科学委员会。
    结果:在一对夫妇不孕症的情况下,应该从一开始就评估双方的生育率,如果ART出现异常或失败,应将患者转介给泌尿外科医师进行专家管理。泌尿外科医师将建立医疗或手术治疗,以改善男性生育能力的预后,与整个艺术团队合作。泌尿科医生/男科医生在受孕前负责男性的健康也很重要,因为对病人自己和他的后代都有好处。
    结论:这项专家共识阐明了男性泌尿系医师在ART途径中的作用,关于男科培训的必要性和所需的医学人口统计。
    BACKGROUND: Following on from the Rapport vers une stratégie nationale de lutte contre l\'infertilité (Report on a national strategy to combat infertility) submitted to the French Minister of Health in 2022, whose objective 13 is: to better identify and diagnose male infertility, we wanted to clarify with reproductive specialists what role the urologist should play in the management of the infertile couple.
    METHODS: An expert consensus was reached with the Pedagogical Committee and pilots of the Transversal Specialized Training in Reproductive Medicine and Biology - Andrology, and with the presidents, board and scientific council of the French Federation for Reproductive Study (FFER).
    RESULTS: In the case of infertility in a couple, the fertility of both partners should be assessed from the outset, and in the event of abnormality or failure of ART, the patient should be referred to a uro-andrologist for expert management. The uro-andrologist will set up medical or surgical treatments to improve the prognosis of the man\'s fertility, in conjunction with the entire ART team. It is also important for the urologist/andrologist to take charge of the man\'s health before conception, because of the benefits for the patient himself and for his offspring.
    CONCLUSIONS: This expert consensus has shed light on the role of the uro-andrologist in the ART pathway, on the need for training in Andrology and on the medical demography required.
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  • 文章类型: Review
    背景:精索静脉曲张是男性不育最常见的可纠正原因。这是最近法国泌尿外科协会(AFU)委员会(CAMS)建议的主题。从那以后,文献提供了更多信息。这篇综述将全面重新评估目前治疗精索静脉曲张的适应症。并根据当前的进展重新审视当代问题。
    方法:作为2020年至2023年期间CAMS建议的一部分进行的文献检索的更新。
    结果:对于临床精索静脉曲张和精子参数异常的不育男性,显微手术腹股沟下精索静脉曲张切除术仍然是首选的手术治疗方法。复发率低于4%。它显著提高了自然和体外受精活产和妊娠率,以及精子数量,总运动和渐进运动,形态学和DNA断裂率。总而言之,它在大约两种情况下的一种情况下修改了MPA策略。精索静脉曲张分级和双侧性可以预测精子参数和妊娠率的改善。不建议治疗亚临床精索静脉曲张。并发症很少见,特别是鞘膜积液(0.5%),单侧睾丸萎缩由于动脉损伤(1/1000),血肿,延迟愈合和术后疼痛。逆行栓塞是手术的替代方法。
    结论:只要有可能,泌尿科医师应与MPA团队和患者一起提出并讨论精索静脉曲张的治疗方案,采取个性化的方法。
    BACKGROUND: Varicocele is the most common correctable cause of male infertility. It was the subject of recent Association française d\'urologie (AFU) Comité d\'andrologie et de médecine sexuelle (CAMS) recommendations. Since then, the literature has provided additional information. This review will comprehensively reassess current indications for the treatment of varicocele, and revisit contemporary issues in the light of current advances.
    METHODS: Update of the literature search carried out as part of the CAMS recommendations for the period between 2020 and 2023.
    RESULTS: Microsurgical sub-inguinal varicocelectomy remains the surgical treatment of choice for infertile men with clinical varicocele and abnormal sperm parameters. It offers recurrence rates of less than 4%. It significantly improves both natural and in vitro fertilization live birth and pregnancy rates, as well as sperm count, total and progressive motility, morphology and DNA fragmentation rates. All in all, it modifies the MPA strategy in around one in two cases. Varicocele grade and bilaterality are predictive of improved sperm parameters and pregnancy rate. Treatment of subclinical varicocele is not recommended. Complications are rare, notably hydroceles (0.5%), unilateral testicular atrophy due to arterial damage (1/1000), hematomas, delayed healing and postoperative pain. Retrograde embolization is an alternative to surgery.
    CONCLUSIONS: Whenever possible, the urologist should present and discuss treatment options for varicocele with the MPA team and the patient, taking a personalized approach.
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  • 文章类型: Journal Article
    深度浸润性子宫内膜异位症是一种严重的疾病,定义为子宫内膜异位组织腹膜浸润。这种疾病可能涉及直肠阴道隔,子宫骶骨韧带,消化道或膀胱。深度浸润性子宫内膜异位症是造成疼痛和不孕的原因。这些建议的目的是回答以下问题:在深度浸润的子宫内膜异位症相关的不孕症的情况下,什么是最好的治疗策略?一线手术,然后体外受精(IVF)在持续不孕症或一线IVF的情况下,没有手术?经过详尽的文献分析,我们提出以下建议:针对深度浸润性子宫内膜异位症不孕患者的自发生育研究发现,自发妊娠率约为10%.患有子宫内膜异位症的不孕妇女希望怀孕时应考虑治疗。在没有手术的深度浸润子宫内膜异位症相关的不孕症的情况下,一线IVF是一个很好的选择。手术后(无大肠受累的深部病变)的妊娠率(自发和以下辅助生殖技术)在40%至85%之间变化。结直肠子宫内膜异位症切除术后,怀孕率从47%到59%不等。比较IVF后怀孕率的研究,无论之前是否手术,是矛盾的,不允许,到目前为止,总结试管婴儿前任何深部病变手术治疗的兴趣。在卵巢储备参数改变的情况下(年龄,AMH,窦卵泡计数),没有理由推荐一线手术或IVF。文献研究没有确定任何预后因素,允许在手术管理或IVF之间进行选择。在“深层浸润性子宫内膜异位症”的适应症中使用IVF可以使妊娠率令人满意,而没有明显的风险,关于疾病进展或卵母细胞取出程序发病率。
    Deeply infiltrating endometriosis is a severe form of the disease, defined by endometriotic tissue peritoneal infiltration. The disease may involve the rectovaginal septum, uterosacral ligaments, digestive tract or bladder. Deeply infiltrating endometriosis is responsible for disabling pain and infertility. The purpose of these recommendations is to answer the following question: in case of deeply infiltrating endometriosis associated infertility, what is the best therapeutic strategy? First-line surgery and then in vitro fertilization (IVF) in case of persistent infertility or first-line IVF, without surgery? After exhaustive literature analysis, we suggest the following recommendations: studies focusing on spontaneous fertility of infertile patients with deeply infiltrating endometriosis found spontaneous pregnancy rates about 10%. Treatment should be considered in infertile women with deeply infiltrating endometriosis when they wish to conceive. First-line IVF is a good option in case of no operated deeply infiltrating endometriosis associated infertility. Pregnancy rates (spontaneous and following assisted reproductive techniques) after surgery (deep lesions without colorectal involvement) varie from 40 to 85%. After colorectal endometriosis resection, pregnancy rates vary from 47 to 59%. The studies comparing the pregnancy rates after IVF, whether or not preceded by surgery, are contradictory and do not allow, to date, to conclude on the interest of any surgical management of deep lesions before IVF. In case of alteration of ovarian reserve parameters (age, AMH, antral follicle count), there is no argument to recommend first-line surgery or IVF. The study of the literature does not identify any prognostic factors, allowing to chose between surgical management or IVF. The use of IVF in the indication \"deep infiltrating endometriosis\" allows satisfactory pregnancy rates without significant risk, regarding disease progression or oocyte retrieval procedure morbidity.
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  • 文章类型: Journal Article
    Endometriosis is a benign chronic inflammatory disease, whose pathogenesis is still unclear. Endometriosis is responsible for infertility and/or pelvic pain. One of the most important features of the disease is the heterogeneity (clinical and anatomical: superficial peritoneal, ovarian and/or deep infiltrating lesions). Bowel involvement constitutes one particularly severe form of the disease, affecting 8-12% of women with deep endometriosis. In case of associated infertility, bowel endometriosis constitutes a real therapeutic challenge for gynecologists. Indeed, while complete resection of the lesions alleviates pain and seems to improve spontaneous fertility, surgery remains technically challenging and may cause severe complications. Reverting to assisted Reproductive Technology (ART) is another valuable therapeutic option regarding pregnancy rates. Thus, the choice between surgical management or ART is still debated. Benefits and risks of these two options should be considered and discussed before planning treatment. In the present study, we aimed to answer the question: Bowel endometriosis and infertility: do we need to operate?
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  • 文章类型: English Abstract
    OBJECTIVE: Sexuality is a fundamental part of the life of the individual and the couple particularly sensitive to the crisis that is infertility. The objective of this review is to describe sexual disorders that may be involved in infertility as well as sexual dysfunctions that can appear during medically assisted reproduction.
    METHODS: We performed a literature reviewed from Medline Database and selected 27 articles.
    RESULTS: Sexual problems are common in infertile couples. Sometimes primary they need to be assessed before the process of assisted reproduction. Mostly secondary (erectile dysfunction, hypoactive sexual desire, decreased sexual activity…), they must be explained and be sought throughout the diagnostic and therapeutic process. A multidisciplinary approach integrating sexological adapted to the specific torque is required and may extend beyond the birth or adoption of the child.
    CONCLUSIONS: In the treatment for infertility it is important to systematically open discussion on issues of sexuality, and to evaluate the significance and severity of sexual dysfunction. Finally, in some cases it is necessary to help patients rebuild their sexuality as a source of pleasure to the end of the period of assisted reproduction.
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