背景:促肾上腺皮质激素(pACTH)的基础(bACTH)和促甲状腺激素释放激素刺激后浓度被推荐用于诊断垂体中层间功能障碍(PPID)。许多因素影响bACTH(例如,疾病,年龄,月),有些只在秋季影响结果(例如,品种,颜色,性)。进食对b/pACTH的影响存在差异。
目的:为了确定是否喂食,月,年龄,品种,颜色,性别和身体状况评分影响b/pACTH。
方法:前瞻性交叉。
方法:将61只动物分为健康组,PPID,处理过的PPID。b/pACTH测量三次(1毫克protirelin;10分钟后采血;11月中旬至7月中旬)在不同的喂养后:禁食,干草,干草+谷物。Friedman检验用于评估饲喂对b/pACTH的影响,并采用线性混合模型来评估其他因素的影响。
结果:喂食对b/pACTH没有显着影响(p=0.7/0.5)。健康人群的bACTH最低(29.3pg/mL,CI9-49.5pg/mL),PPID组最高(58.9pg/mL,CI39.7-78.1pg/mL)。健康人群的pACTH显着降低(396.7pg/mL,CI283.2-510.1pg/mL)与PPID(588.4pg/mL,CI480.7-696.2pg/mL)和治疗的PPID组(683.1pg/mL,CI585.9-780.4pg/mL),7月最高(881.2pg/mL,CI626.3-1136.3pg/mL)及更高的灰色(723.5pg/mL,CI577.5-869.4pg/mL)比其他颜色(338.7pg/mL,CI324.8-452.5pg/mL)。这些变量的效应大小>0.5。
结论:动物数量少,每匹马随后的bACTH测量值显著较低.
结论:没有证据表明进食会影响b/pACTH。有证据表明培高利特影响bACTH,但对pACTH影响不大。需要进一步研究月份和涂层颜色对b/pACTH的影响,以更好地解释结果。
BACKGROUND: The basal (bACTH) and post-thyrotropin-releasing hormone stimulation concentration of
adrenocorticotropin (pACTH) are recommended for diagnosis of pituitary pars intermedia dysfunction (PPID). Many factors influence bACTH (e.g., disease, age, month) and some affect the results only in autumn (e.g., breed, colour, sex). There are discrepancies about the impact of feeding on b/pACTH.
OBJECTIVE: To determine whether feeding, month, age, breed, colour, sex and body condition score affect b/pACTH.
METHODS: Prospective crossover.
METHODS: Sixty-one animals were divided into groups: healthy, PPID, treated-PPID. The b/pACTH was measured three times (1 mg protirelin; blood collection after 10 min; mid-November to mid-July) after different feedings: fasting, hay, hay + grain. Friedman\'s test was applied to evaluate the influence of feeding on b/pACTH and linear mixed model to evaluate impact of further factors.
RESULTS: The b/pACTH was not significantly affected by feeding (p = 0.7/0.5). The bACTH was lowest in healthy (29.3 pg/mL, CI 9-49.5 pg/mL) and highest in PPID-group (58.9 pg/mL, CI 39.7-78.1 pg/mL). The pACTH was significantly lower in healthy (396.7 pg/mL, CI 283.2-510.1 pg/mL) compared to PPID (588.4 pg/mL, CI 480.7-696.2 pg/mL) and treated-PPID group (683.1 pg/mL, CI 585.9-780.4 pg/mL), highest in July (881.2 pg/mL, CI 626.3-1136.3 pg/mL) and higher in grey (723.5 pg/mL, CI 577.5-869.4 pg/mL) than other colours (338.7 pg/mL, CI 324.8-452.5 pg/mL). The size of effect for those variables was >0.5.
CONCLUSIONS: Small number of animals, subsequent bACTH measurements were significantly lower in each horse.
CONCLUSIONS: There was no evidence that feeding influences the b/pACTH. There was evidence that pergolide affects the bACTH but it had little effect on pACTH. Further investigation of the impact of month and coat colour on b/pACTH is warranted to better interpret the results.