眼科疾病可以表现为急性疾病,如过敏,眼部感染,等。,或者可以表现为系统性疾病的慢性疾病,像糖尿病一样,甲状腺,风湿病,和其他人。壳聚糖(CS)及其衍生物作为纳米载体在药物传递中的作用已被广泛研究,基因,和许多生物制品。CS的生物相容性和生物降解性使其成为许多成分的眼部递送的良好候选物,包括免疫调节剂,抗生素,高眼压药物,等。已经成功报道了基于CS的纳米系统通过穿透生物眼屏障以及靶向和控制药物释放来调节眼部疾病。这篇综述为药物输送配方设计师提供了关于最近发表的策略的指导,这些策略可以增强基于CS的纳米系统中眼组织的药物渗透,从而通过提高药物生物利用度提高治疗效果。这篇综述将强调在纳米递送系统中观察到的药物递送的主要眼部屏障。此外,讨论了有助于配方方面的CS理化性质。它还将可以在基于CS的纳米系统中优化的渗透增强策略分为四个方面:与CS相关的物理化学性质,配方成分,制造条件,采用像植入物这样的新型输送系统,插入,等。正如在过去十年内发表的文献中所描述的那样。最后,提到了基于CS的纳米系统中遇到的挑战和未来的前景。
Ophthalmic diseases can be presented as acute diseases like allergies, ocular infections, etc., or chronic ones that can be manifested as a result of systemic disorders, like diabetes mellitus, thyroid, rheumatic disorders, and others. Chitosan (CS) and its derivatives have been widely investigated as nanocarriers in the delivery of drugs, genes, and many biological products. The biocompatibility and biodegradability of CS made it a good candidate for ocular delivery of many ingredients, including immunomodulating agents, antibiotics, ocular hypertension medications, etc. CS-based nanosystems have been successfully reported to modulate ocular diseases by penetrating biological ocular barriers and targeting and controlling drug release. This review provides guidance to drug delivery formulators on the most recently published strategies that can enhance drug permeation to the ocular tissues in CS-based nanosystems, thus improving therapeutic effects through enhancing drug bioavailability. This review will highlight the main ocular barriers to drug delivery observed in the nano-delivery system. In addition, the CS physicochemical properties that contribute to formulation aspects are discussed. It also categorized the permeation enhancement strategies that can be optimized in CS-based nanosystems into four aspects: CS-related physicochemical properties, formulation components, fabrication conditions, and adopting a novel delivery system like implants, inserts, etc. as described in the published literature within the last ten years. Finally, challenges encountered in CS-based nanosystems and future perspectives are mentioned.