Adenomyoma

腺肌瘤
  • 文章类型: Case Reports
    盆腔肿块通常起源于盆腔,通常与子宫有关。卵巢,或肠道疾病。本报告描述了我院诊断为腹膜后皮样囊肿的盆腔肿块患者的情况。我们对这个案例进行了分析和文献综述,减少误诊风险,加强腹膜后肿块的治疗。
    Pelvic masses frequently originate from the pelvic cavity and are often associated with uterine, ovarian, or intestinal disorders. This report describes the case of a patient with a pelvic mass diagnosed as a retroperitoneal dermoid cyst at our hospital. We analyzed this case and conducted a literature review, to mitigate the risk of misdiagnosis and enhance the treatment of retroperitoneal masses.
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  • 文章类型: Journal Article
    We report a case of alpha-fetoprotein-producing endometrioid carcinoma (AFP-EC) that originated within an adenomyoma of the uterine corpus. A 76-year-old Japanese woman was incidentally discovered to have a uterine tumor along with multiple lung nodules. Upon surgical removal of the uterus, it was revealed that the tumor was situated within the adenomyoma. The tumor exhibited microfollicular structures and solid growth patterns, with hyaline globules, clear cell glands, and primitive tumor cells. Immunohistochemical analysis indicated the presence of germ cell markers, including AFP, SALL4, and glypican3, leading to final diagnosis of AFP-EC. Histopathologically, AFP-ECs exhibit characteristics similar to those of AFP-producing neoplasms in other organs. Furthermore, a nomenclature issue arises when distinguishing AFP-ECs from yolk sac tumors of the endometrium in older patients due to their shared features. The concept of retrodifferentiation or neometaplasia suggests that \"endometrioid carcinoma with yolk sac tumor differentiation\" or \"endometrioid carcinoma with a primitive phenotype\" may serve as more fitting terms for the diverse spectrum of AFP-producing neoplasms in the endometrium. In conclusion, this case underscores the diagnostic challenges posed by AFP-ECs arising from adenomyomas and emphasizes the need for refining the nomenclature and classification of AFP-producing neoplasms within the endometrium.
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  • 文章类型: Journal Article
    子宫腺肌病是一种复杂的病理状况,对子宫产生负面影响。它与更广为人知的子宫内膜异位症密切相关,它在诊断方面有相似之处,治疗,微观和宏观特征。这种叙事回顾的目的是给出一个明确的定义和不同的展望,适应患者,手术治疗。关于这些主题的MEDLINE和PubMed搜索是在1990年至2022年期间使用选定的关键字进行的。经过作者的修订和评估,确定了论文和文章并将其纳入本叙述性综述。从文献分析来看,作者报告了以下手术技术:腹腔镜双/三瓣法,腹腔镜子宫壁楔形切除术,开腹子宫壁横切H型切口,腹腔镜楔形切除术,通过不对称解剖技术进行腹腔镜完全切除。这些技术都有优点和缺点,但是关于怀孕率的文献资料有些有限。唯一的某些信息是子宫腺肌病手术治疗后子宫破裂的风险高达6.0%。多年来,通过微创治疗,手术方法继续取得积极效果,住院次数减少,术后疼痛减少,减少失血。多年来,妇科医生获得了技能,培训和日益复杂的手术技术,以有效的治疗为目标。这就是为什么子宫切除术不再是治疗子宫腺肌病的唯一手术资源,但是在希望保持生育能力的患者中,有各种各样的手术选择。
    Adenomyosis is an intricate pathological condition that negatively impacts the uterus. It is closely related to the more well-known endometriosis, with which it shares parallels in terms of diagnosis, therapy, and both microscopic and macroscopic features. The purpose of this narrative review is to give a clear univocal definition and outlook on the different, patient-adapted, surgical treatments. MEDLINE and PubMed searches on these topics were conducted from 1990 to 2022 using a mix of selected keywords. Papers and articles were identified and included in this narrative review after authors\' revision and evaluation. From the literature analysis, authors reported the following surgical techniques: laparoscopic double/triple-flap method, laparotomic wedge resection of the uterine wall, laparotomic transverse H-incision of the uterine wall, laparotomic wedge-shaped excision, and laparotomic complete debulking excision by asymmetric dissection technique. Each of these techniques has strengths and weaknesses, but the literature data on the pregnancy rate are somewhat limited. The only certain information is the risk of uterine rupture up to 6.0% after surgical treatment for uterine adenomyosis. Over the years, the surgical approach continued to reach a positive result by minimally invasive treatment, with less hospitalization, less postoperative pain, and less blood loss. Over the years, the gynecological surgeon has gained the skills, training and increasingly sophisticated surgical techniques to target effective therapy. That\'s why a hysterectomy is no longer the only surgical resource to treat adenomyosis, but in patients who wish to preserve the fertility, there is a wide variety of surgical alternatives.
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  • 文章类型: Journal Article
    目的:评估经皮图像引导下的腺肌瘤冷冻消融术的有效性和安全性材料和方法:5名有症状的妇女希望保留她们的子宫和生育能力,接受了一次经皮图像引导下的腺肌瘤冷冻消融术。在超声和腹腔镜引导下,将三到六个17号冷冻探针经皮插入腺肌瘤。临床疗效定义为疼痛视觉模拟评分(VAS)的减少,治疗后12个月通过子宫内膜异位症健康状况(EHP-5)评估子宫出血的减少和生活质量的改善.通过MRI上每个治疗的腺肌瘤的体积减少来定义技术功效。使用Clavien-Dindo分类系统对并发症进行分类。手术后至少3个月进行了子宫检查。
    结果:与基线相比,12个月后所有症状评分均下降:VAS中位数8/10(范围,5-10)到4/10(范围,0-7);性交困难中位数评分7/10(范围,0-10)到2/10(范围,0-8);中位出血评分335(范围,102-920)至76(范围,0-88);EHP-5评分中位数60/100(范围,50-75)至50/100(范围,32-55).子宫腺肌病的中位体积从57cm3(范围,8-87)至9cm3(范围,2-45)在12个月。术后无并发症发生。两名患者宫腔粘连不全,可以通过宫腔镜轻松清除。
    结论:冷冻消融术可能是希望保留子宫的女性症状性腺肌瘤的一种有希望的替代治疗方法。
    OBJECTIVE: To assess the efficacy and safety of percutaneous image-guided cryoablation of adenomyomas MATERIAL AND METHODS: Five symptomatic women who wanted to preserve their uterus and fertility underwent a single session of percutaneous image-guided cryoablation of adenomyoma. Three to six 17-gauge cryoprobes were introduced percutaneously into the adenomyoma under ultrasound and laparoscopy guidance. Clinical efficacy was defined as the diminution of the Visual Analogue Scale of pain (VAS), the decrease in uterine bleeding and the improvement of quality of life assessed by the endometriosis health profile 5 (EHP-5) 12 months after treatment. Technical efficacy was defined by the reduction in volume of each treated adenomyoma on MRI. Complications were classified using the Clavien-Dindo classification system. Hysterosonography was performed at least 3 months after the procedure.
    RESULTS: Compared to the baseline, all symptom scores had decreased after 12 months: median VAS 8/10 (range, 5-10) to 4/10 (range, 0-7); median dyspareunia score 7/10 (range, 0-10) to 2/10 (range, 0-8); median bleeding score 335 (range, 102-920) to 76 (range, 0-88); median EHP-5 score 60/100 (range, 50-75) to 50/100 (range, 32-55). The median volume of adenomyosis decreased from 57 cm3 (range, 8-87) to 9 cm3 (range, 2-45) at 12 months. No postoperative complications occurred. Two patients had incomplete intrauterine adhesions that were easily removed hysteroscopically.
    CONCLUSIONS: Cryoablation may be a promising alternative treatment for symptomatic adenomyoma in women who want to preserve their uterus.
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  • 文章类型: Journal Article
    放射科医师在许多成像方式中通常会遇到胆囊腺肌瘤病。胆囊腺肌瘤病的经典影像学表现得到了很好的描述,并证实了良性。然而,在临床实践中,子宫腺肌病与其他需要胆囊切除术的胆囊病变可能具有挑战性。在这篇文章中,我们在多模态成像上描述了胆囊腺肌瘤病的常见和罕见表现,帮助区分子宫腺肌瘤病与非良性胆囊异常。准确区分腺肌瘤病及其模拟体为手术团队提供了重要的临床和手术管理信息,改善患者预后。
    Radiologists across many imaging modalities commonly encounter gallbladder adenomyomatosis. The classic imaging appearances of gallbladder adenomyomatosis are well described and confirm benignity. However, in clinical practice, adenomyomatosis can be challenging to differentiate from other gallbladder pathologies that require cholecystectomy. In this article, we describe the common and uncommon appearances of gallbladder adenomyomatosis on multimodality imaging, helping differentiate adenomyomatosis from non-benign gallbladder abnormalities. Accurately differentiating adenomyomatosis from its mimics provides the surgical team with important clinical and surgical management information, improving patient outcomes.
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  • 文章类型: Review
    背景:子宫腺肌病,一种以子宫肌层内的子宫内膜组织为特征的妇科疾病,经常导致月经疼痛和大量出血,显著影响生活质量。子宫腺肌病和平滑肌瘤的主要治疗方法是子宫切除术。然而,在极少数情况下,子宫切除术后,这些情况可能会在宫颈残端复发。这里,我们介绍了1例宫颈腺肌瘤在腹腔镜下子宫切除术后发展的病例。
    方法:一名47岁女性因阴道出血增加而求医。
    方法:她在7年前接受了腹腔镜子宫上切除术,以治疗子宫肌瘤和子宫腺肌病。子宫切除术后一个月,盆腔超声显示存在大约4.0×4.0厘米的宫颈残端。随后的随访超声记录了宫颈肿块的逐渐生长。两年前,发现了一个复发性肌瘤,患者出现间歇性阴道出血。超过7年,宫颈肿块从4厘米增加到7厘米。入院前盆腔超声检查证实存在7×6cm的宫颈腺肌瘤。
    方法:因此,该患者接受了腹腔镜下胆囊切除术。术中,扩大的子宫颈,尺寸约为7×6厘米,观察到含有腺肌瘤。标本的大体检查表明肥大的肌肉组织和出血性病灶。随后的组织病理学检查证实存在腺肌瘤。
    结果:值得注意的是,患者在随后的8个月内未出现复发.
    结论:这里介绍的病例强调了宫颈子宫切除术后宫颈腺肌瘤的潜在发生。管理选择包括激素治疗和手术切除。此外,建议对宫颈上子宫切除术患者进行包括超声和子宫颈抹片检查在内的年度随访,以发现和解决可能的复发.
    BACKGROUND: Adenomyosis, a gynecological condition characterized by endometrial tissue within the uterine myometrium, often leads to menstrual pain and heavy bleeding, significantly affecting the quality of life. The primary treatment for adenomyosis and leiomyomas is hysterectomy. However, in rare instances, these conditions can recur in the cervical stump following a hysterectomy.Here, we present a case of cervical adenomyoma development after a prior laparoscopic supracervical hysterectomy.
    METHODS: A 47-year-old woman sought medical attention due to increased vaginal bleeding.
    METHODS: She had undergone a laparoscopic supracervical hysterectomy 7 years earlier to address uterine myoma and adenomyosis. Just 1 month posthysterectomy, a pelvic ultrasound revealed the presence of a cervical stump measuring approximately 4.0 × 4.0 cm. Subsequent follow-up ultrasounds documented the gradual growth of the cervical mass. Two years ago, a recurrent myoma was identified, and the patient experienced intermittent vaginal bleeding. Over 7 years, the cervical mass increased from 4 to 7 cm. Preadmission pelvic ultrasonography confirmed the existence of cervical adenomyoma measuring 7 × 6 cm.
    METHODS: Consequently, the patient underwent a laparoscopic trachelectomy. Intraoperatively, an enlarged cervix, approximately 7 × 6 cm in size, containing adenomyoma was observed. A gross examination of the specimen indicated hypertrophic muscle tissue and hemorrhagic foci. Subsequent histopathological examination confirmed the presence of adenomyoma.
    RESULTS: Remarkably, the patient exhibited no recurrence over the subsequent 8 months.
    CONCLUSIONS: The case presented here highlights the potential occurrence of cervical adenomyoma following a supracervical hysterectomy. Management options include hormone therapy and surgical excision. Furthermore, annual follow-up comprising ultrasound and pap smear evaluations is recommended for patients with supracervical hysterectomies to detect and address possible recurrences.
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  • 文章类型: Case Reports
    背景技术肠套叠是婴儿期常见的腹部急症,需要立即诊断和治疗干预。在大约90%的案例中,肠套叠似乎是特发性的.据报道,肠套叠与回肠末端的Peyer斑块的淋巴样增生有关,可能是触发因素。临床表现差异很大,而在大多数报道的病例中,病因似乎是特发性的。病例报告该病例描述了一个先前健康的2个月大的女孩,在就诊前的12小时内出现了非胆汁性呕吐和恶化的发作。腹部超声显示右髂窝有典型的靶征象,没有可见的蠕动,确认肠套叠的诊断。非手术复位失败导致紧急剖腹手术,并因Meckel憩室而诊断为肠套叠。然而,剖腹手术显示小肠腺肌瘤,一种罕见的良性肿瘤样病变,作为病理线索。结论这个案例有两个不同的原因。它不仅强调了对触发因素保持高怀疑指数的必要性,即使在非典型受影响年龄组的患者中,但它也增加了所报道的小肠腺肌瘤作为肠套叠病理引导点的显著有限的选择。在这个案例报告中,我们渴望强调,特别是在受影响最严重的年龄组之外的患者中,儿科医生应继续意识到子宫腺肌瘤作为病理线索的可能性.
    BACKGROUND Intussusception is a frequent abdominal emergency in infancy, requiring immediate diagnosis and therapeutic intervention. In approximately 90% of cases, intussusception seems to be idiopathic. There has been a reported association of intussusception with lymphoid hyperplasia of Peyer patches in the terminal ileum, possibly acting as the triggering factor. Clinical presentation varies substantially, while the etiology seems idiopathic in most reported cases. CASE REPORT This case describes a previously healthy 2-month-old girl who presented with an episode of non-bilious vomiting and deterioration during the 12 hours preceding the visit. Abdominal ultrasonography revealed the typical target sign in the right iliac fossa, without visible peristalsis, confirming the diagnosis of intussusception. Failure of non-surgical reduction led to emergency laparotomy with the working diagnosis of intussusception due to Meckel\'s diverticulum. However, laparotomy instead revealed an adenomyoma of the small intestine, a rare benign tumor-like lesion, as the pathological lead point. CONCLUSIONS This case is interesting for 2 distinct reasons. Not only does it underline the need to maintain a high index of suspicion for triggering factors, even in patients within atypically affected age groups, but it also adds to the remarkably limited selection of reported adenomyomas of the small intestine acting as the pathological lead point for intussusception. In this case report, we aspire to emphasize that especially in patients outside the most affected age group, pediatric surgeons should remain aware of the possibility of adenomyoma as a pathological lead point.
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  • 文章类型: Case Reports
    尽管异位胰腺通常发生在胃中,很少表现为粘膜下肿瘤,准确的术前诊断往往是困难的,因为不同的临床症状和结果取决于病变的大小和位置。我们经历了一例III型胃异位胰腺,表现为胃窦的胃腺肌瘤。一名62岁的妇女因上腹不适前往当地医院。食管胃十二指肠镜检查研究表明,胃窦曲率较大的粘膜下肿瘤。由于肿瘤增大,患者接受了手术切除。切除标本的组织学切片显示,肿瘤由高耸的柱状上皮和突出的平滑肌基质组成,没有非典型细胞。肿瘤与HeinrichIII型异位胰腺相容,表现为胃腺肌瘤。这些发现提供了有用的组织学特征,并对更好地了解胃窦腺肌瘤和异位胰腺的胚胎起源和发育提供了一些见解。
    Although heterotopic pancreas usually occurs in the stomach and rarely presents as a submucosal tumor, an accurate preoperative diagnosis is often difficult because of the variety of clinical symptoms and findings depending on the size and location of the lesion. We experienced a case of gastric type III heterotopic pancreas presenting as a gastric adenomyoma in the antrum of the stomach. A 62-year-old woman visited a local hospital for epigastric discomfort. An esophagogastroduodenoscopy study indicated a submucosal tumor in the greater curvature of the gastric antrum. The patient underwent surgical resection of the tumor because it was enlarged. The histological sections of the resected specimen showed that the tumor was composed of ductular structures lined by tall columnar epithelia and a prominent smooth muscle stroma with no atypical cells. The tumor was compatible with Heinrich\'s type III heterotopic pancreas, which presented as an adenomyoma of the stomach. These findings provide useful histological features and some insight into a better understanding of the embryonic origin and development of adenomyoma and heterotopic pancreas in the antrum of the stomach.
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  • 文章类型: Journal Article
    目的:腺肌瘤是一种罕见的小肠错构瘤。关于这种罕见疾病特征的报道很少。这项研究的目的是描述小肠腺肌瘤的超声(US)特征。材料和方法:本回顾性研究分析了2014-2021年我院15例年龄在1天至12岁之间的小肠腺肌瘤患儿的临床特征和US资料。
    结果:所有小肠腺肌瘤的临床表现均为腹痛,呕吐或/和血氧。小肠腺肌瘤通常是继发性肠套叠的导点。它们在回肠中被识别(n=11),空肠(n=2),和Meckel憩室(n=2)。小肠腺肌瘤的诊断准确率(US诊断与病理诊断的符合率)为73.3%。小肠腺肌瘤约1.0-3.0cm,通常位于粘膜下区域,基部宽,没有椎弓根,它的界限很清楚。肿块突出到肠腔,并显示椭圆形低回声多囊回声结节,包含多个不同大小的小的准圆形或不规则囊肿,周围是固体低回声马赛克区域。彩色多普勒超声显示在实质性低回声区域的大量或稀疏的血流信号。结论儿童小肠腺肌瘤的US表现具有特征性,而US在儿童肠子宫腺瘤的鉴别中很有价值。
    OBJECTIVE: Adenomyoma is an exceptionally rare hamartoma in the small intestine. Few data have been reported on the features of this rare disease. The aim of this study was to describe the ultrasound (US) characteristics of small intestinal adenomyomas. Material and methods: This retrospective study analyzed the clinical features and US data of 15 pediatric patients diagnosed as small intestinal adenomyomas in the age range between 1 day to 12 years in our hospital during 2014-2021.
    RESULTS: The clinical manifestations of all the small intestinal adenomyomas were abdominal pain, vomiting or/and hemafecia. The small intestinal adenomyoma usually acted as the lead point of secondary intussusception. They were identified in the ileum (n=11), jejunum (n=2), and Meckel\'s diverticulum (n=2). The diagnostic accuracy (the concordance rate between US diagnosis and pathological diagnosis) of small intestinal adenomyoma was 73.3%. The small intestinal adenomyoma had approximately 1.0-3.0 cm, were typically located in the submucosal region, had the basal part wide and without a pedicle, and its boundaries were clear. The mass protruded into the intestinal cavity, and showed oval hypoechoic polycystic echo nodules, containing multiple small quasi-circular or irregular cysts of different sizes surrounded by solid hypoechoic mosaic areas. The color Doppler US showed in the solid hypoechoic areas of the mass abundant or sparse blood flow signals.Conclusions The US findings of small intestinal adenomyomas in children are characteristic, and US is valuable in the identification of intestinal adenomyomas in children.
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  • 文章类型: Systematic Review
    目的:描述1例子宫外腺肌瘤(EA),并回顾文献中所有EA的病例。
    方法:Pubmed/MEDLINE,Embase,和谷歌学者从1807年到2022年12月。所有研究报告了EA的组织学诊断。我们收集了以下数据:患者的年龄,腺肌瘤的大小和位置,子宫内膜异位症和子宫腺肌病的存在,过去的妇科治疗,症状,诊断成像,手术干预,替代/辅助治疗,相关恶性肿瘤,并跟进。
    结果:纳入了67项研究,共85名患者。疼痛是最常见的症状(69.5%)。在诊断检查中,在81例报告病例中,有60例使用了超声检查,描述了几种放射学特征。在77.6%的患者中,EA位于骨盆内。附件是该病最常见的部位(24,28.2%)。35例患者(35,41.2%)描述了子宫内膜异位症或子宫腺肌症的病史。85例患者中有6例(7.1%)报告了子宫组织碎裂。85例患者中有9例检测到相关恶性肿瘤(10.6%)。有两次疾病复发。
    结论:EA的具体成像特征尚未在文献中描述。子宫内膜异位症和子宫腺肌病或子宫组织碎裂的病史可能提示EA。组织学检查可以明确诊断并排除恶变。
    OBJECTIVE: To describe a case of extrauterine adenomyoma (EA) and review all the cases of EA in the literature.
    METHODS: Pubmed/MEDLINE, Embase, and Google Scholar from 1807 to December 2022. All studies reporting the histologic diagnosis of an EA. We collected the following data: patient\'s age, size and location of adenomyoma, presence of endometriosis and adenomyosis, past gynecologic treatment, symptoms, diagnostic imaging, surgical intervention, alternative/adjuvant treatment, associated malignancy, and follow up.
    RESULTS: Sixty-seven studies with 85 patients were included. Pain was the most frequent symptom (69.5%). Among diagnostic examinations, ultrasonography was used in 60 out of 81 reported cases, with several radiologic features described. EA was located inside the pelvis in 77.6% of patients. Adnexa were the most frequent site of the disease (24, 28.2%). History of endometriosis or adenomyosis was described in 35 patients (35, 41.2%). Uterine tissue morcellation was reported in 6 of the 85 patients (7.1%). Associated malignancy was detected in 9 out of 85 patients with available data (10.6%). There were two recurrences of disease.
    CONCLUSIONS: Specific imaging features of EA are yet to be described in the literature. History of endometriosis and adenomyosis or uterine tissue morcellation may be suggestive of EA. Histologic examination can give a definitive diagnosis and exclude malignant transformation.
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