目的:这项新颖的研究旨在了解生活经验和照顾者对使用适应性试验评估饮食失调干预措施的看法。除了从生活经验的角度了解饮食失调研究和治疗中最重要的因素和结果。
方法:共有73名具有在世或照顾者经验的人同意,70开始问卷,36个(51%)完成了所有问题。向参与者询问Likert量表和开放式问题,以了解饮食失调干预措施的哪些因素和结果对他们最重要,并了解他们对临床试验的先前知识。然后使用两个视频来解释随机对照试验(RCT)和适应性试验,并询问参与者的意见。包括感知到的利益和担忧,每种试验类型。
结果:主题分析发现了关于饮食失调治疗中重要因素的两个关键主题:以人为本的护理和循证有效的治疗;关于治疗结果的两个关键主题:持续,完全恢复和更大的前景。RCT和适应性试验都得到了好评,然而,对适应性试验有轻微的偏好.展示的感知利益和道德的关键主题,实用,每个人都有独特的科学考虑。
结论:研究结果表明,适应性试验支持有生活经验的人及其照顾者的饮食失调干预措施。建议研究人员在设计未来的干预试验时考虑使用自适应设计和结合生活经验观点。
■这项新颖的研究发现,在饮食失调干预研究中使用适应性试验得到了有生活经验的人和照顾者的支持。此外,本研究中对参与者最重要的因素和结局与之前在新兴文献中确定的因素和结局具有可比性.在进一步的临床试验中,建议使用适应性设计和结合生活经验。
OBJECTIVE: This novel study sought to understand lived experience and carer perspectives on the use of adaptive trials to evaluate interventions for eating disorders, in addition to understanding the factors and outcomes of most importance in eating disorder research and treatments from a lived experience perspective.
METHODS: A total of 73 people with either lived or carer experience consented, 70 started the questionnaire, and 36 (51%) completed all questions. Participants were asked Likert scale and open-ended questions to understand what factors and outcomes of eating disorder interventions were most important to them and understand their pre-existing knowledge of clinical trials. Two videos were then used to explain randomized controlled trials (RCTs) and adaptive trials and participants were asked their opinions, including perceived benefits and concerns, of each trial type.
RESULTS: The thematic analysis found two key themes regarding factors important in eating disorder treatment: Person-centred care and Evidence-based and effective treatment; and two key themes regarding outcomes of treatment: Sustained, full recovery and The bigger picture. Both RCTs and adaptive trials were viewed favorably, however, there was a slight preference for adaptive trials. Key themes for both demonstrated perceived benefits and ethical, practical, and scientific considerations unique to each.
CONCLUSIONS: Findings demonstrate the support of adaptive trials in eating disorder interventions from people with lived experience and their carers. It is recommended that researchers consider the use of adaptive designs and the incorporation of lived experience perspectives when designing future intervention trials.
UNASSIGNED: This novel study found that the use of adaptive trials in eating disorder intervention research is supported by people with lived experience and carers. Furthermore, the factors and outcomes of most importance to participants in this study are comparable to those previously identified in the emerging literature. The use of adaptive designs and the incorporation of lived experience are recommended in further clinical trials.