未经证实:急性Stanford-A主动脉夹层(AAAD)是一种高死亡率的破坏性心血管疾病,因此,确定危险预后因素对于AAAD患者的危险分层至关重要.这里,我们调查了AAAD患者的外周血嗜酸性粒细胞(EOS)计数及其可能的生物学意义.
UNASSIGNED:我们进行了单中心回顾性队列研究。从2011年到2021年,共有1,190名患者接受了AAAD手术。患者首先按死亡和入院EOS计数分类(0.00×109/L或>0.00×109/L)。人口统计,实验室数据,和结局采用标准统计分析进行分析.升主动脉标本用于蛋白质印迹和组织学评估。
UNASSIGNED:死亡组患者的EOS计数低于非死亡组(P=0.008)。当使用平均血液EOS计数对患者进行分层时:681例患者的计数较低(0.00×109/L),499例患者的计数较高(>0.00×109/L)。与EOS计数正常的患者相比,入院时EOS计数较低的患者更有可能有更高的死亡风险(P=0.017)和在重症监护病房(ICU)中更长的治疗天数(P=0.033)。此外,两组间凝血五项差异有统计学意义(P<0.001)。升主动脉假腔的苏木精和伊红染色的横截面显示,在主动脉假腔的血栓中很容易观察到EOS。
未经证实:外周血EOS计数可能与血栓形成有关,可能是诊断的有效指标,评估,并对AAAD患者进行预后监测。
UNASSIGNED: Acute Stanford-A aortic dissection (AAAD) is a devastating cardiovascular condition with high mortality, therefore identifying risk prognosis factors is vital for the risk stratification of patients with AAAD. Here, we investigated peripheral blood eosinophil (EOS) counts in patients with AAAD and their possible biological implications.
UNASSIGNED: We performed a single center retrospective cohort study. From 2011 to 2021, a total of 1,190 patients underwent AAAD surgery. Patients were categorized first by death and then admission EOS counts (0.00 × 109/L or >0.00 × 109/L). Demographics, laboratory data, and outcomes were analyzed using standard statistical analyses. Ascending aorta specimens were used for western blotting and histological assessments.
UNASSIGNED: Death group patients had lower EOS counts than the non-death group (P = 0.008). When patients were stratified using mean blood EOS counts: 681 patients had low (0.00 × 109/L) and 499 had high (>0.00 × 109/L) counts. Patients with low EOS counts at admission were more likely to have a higher mortality risk (P = 0.017) and longer treatment in the intensive care unit (ICU) days (P = 0.033) than patients with normal EOS counts. Also, the five blood coagulation items between both groups showed significantly different (P < 0.001). Hematoxylin & eosin-stained cross-sections of the ascending aorta false lumen showed that EOSs were readily observed in thrombi in the false lumen of the aorta.
UNASSIGNED: Peripheral blood EOS counts may be involved in thrombosis and could be an effective and efficient indicator for the diagnosis, evaluation, and prognosis monitoring of patients with AAAD.