Achilles tendinopathy

跟腱病
  • 文章类型: Journal Article
    插入性跟腱病是一个伞形医学术语,指的是跟骨后部的疼痛和肿胀。高分辨率超声成像在日常实践中通常用于评估跟腱的病理变化,跟骨皮质骨,和位于跟骨后间隙内的软组织,以优化相关患者的管理。据我们所知,相关文献中缺乏评估跟骨法囊后复合体的标准化超声方案。在这个意义上,我们的逐步超声检查方法旨在为超声医师/医师在日常实践中评估跟腱病患者的这种解剖复合体提供简单易用的指南.不用说,这种V形滑膜/纤维软骨囊围绕Kager脂肪垫的后下楔形和跟骨后间隙的特殊组织学特征使检查具有挑战性。
    Insertional Achilles tendinopathy is an umbrella medical term referring to pain and swelling on the posterior aspect of the calcaneus. High-resolution ultrasound imaging is commonly used in daily practice to assess the pathological changes of the Achilles tendon, cortical bone of the calcaneus, and soft tissues located inside the retrocalcaneal space to optimize the management of relevant patients. To the best of our knowledge, a standardized ultrasound protocol to evaluate the retrocalcaneal bursal complex is lacking in the pertinent literature. In this sense, our step-by-step sonographic approach is intended to be an easy and ready-to-use guide for sonographers/physicians in daily practice to assess this anatomical complex in patients with Achilles tendinopathy. Needless to say, the peculiar histological features of this V-shaped synovial/fibrocartilaginous bursa surrounding the posteroinferior wedge of the Kager\'s fat pad and the retrocalcaneal space make the examination challenging.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    在过去的十年中,关节镜手术由于其相当大的优势,已经取代了Haglund疾病治疗中的开放技术。内窥镜跟骨成形术是一种允许切除跟后上骨外生症和跟骨后滑囊炎的技术。本文的目的是描述该技术并报告其临床和主观结果。
    对2014年7月至2020年3月期间在单一学术机构接受内镜Haglund切除术的连续患者进行了回顾性研究。所有患者均亲自调查疼痛程度(视觉模拟量表),它的位置(中央,横向,内侧或弥漫性),它与休息的关系,或身体活动。使用美国骨科足踝协会AOFAS设计的后足量表评估临床评估。
    在这项研究中,14例患者进行了14例内镜下跟骨成形术,平均随访40个月。视觉模拟量表评分从术前的平均值9.07提高到术后的1.8(P>.0001)。AOFAS评分从术前38.7升至术后94.6(P>.0001)。12例(85.7%)患者主观效果良好,他们都会再次做手术。无伤口并发症或感染。无患者需要再次手术。
    在这个相对较小的群体中,我们发现内窥镜跟骨成形术具有良好的临床和主观效果,且并发症少.
    UNASSIGNED: During the last decade, arthroscopic procedures have been replacing open techniques in Haglund disease treatment because of their considerable advantages. Endoscopic calcaneoplasty is a technique that allows resection of posterosuperior calcaneal exostosis and retrocalcaneal bursitis. The objective of this article was to describe this technique and report its clinical and subjective outcome.
    UNASSIGNED: A retrospective study was performed of consecutive patients undergoing endoscopic Haglund resection surgery between July 2014 and March 2020 at a single academic institution. All patients were surveyed in person about the level of pain (visual analog scale), its location (central, lateral, medial or diffuse), its relation with rest, or physical activity. Clinical evaluation was assessed using the hindfoot scale designed by the American Orthopedics Foot & Ankle Society AOFAS.
    UNASSIGNED: In this study, 14 endoscopic calcaneoplasties were performed in 14 patients, with an average follow-up of 40 months. The visual analog scale score improved from a preoperative average value of 9.07 to 1.8 after surgery (P > .0001). The AOFAS scale rose from 38.7 before surgery to 94.6 postoperative (P > .0001). Good subjective results were observed in 12 patients (85.7%), and all of them would have surgery again. There were no wound complications or infections. No patient required reoperation.
    UNASSIGNED: In this relatively small cohort, we found that endoscopic calcaneoplasty was associated with good clinical and subjective results with few complications.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    跟腱在个体之间表现出肌腱下扭曲的解剖学差异,它的顺应性可能会因为跟腱病等疾病而改变。然而,当前的肌肉骨骼模型忽略了这些材料和形态变化。本研究旨在探讨改变跟腱插入点和顺应性对肱三头肌肌力的影响。因此肌腱负荷,在一名跟腱病患者的动态锻炼过程中。首先,基于特定于受试者的3D徒手超声模型和三种类型的肌腱下扭曲,在肌肉骨骼模型中改变了肌腱下插入点:低,中等,和高。第二,基于实验值对肌腱顺应性进行建模,创建三个肌肉骨骼模型:兼容,意思是,和僵硬。结果表明,肌腱顺应性对肱三头肌肌力的影响大于肌腱扭曲。与无扭曲模型相比,将肌腱下插入点更改为三种类型的扭曲显示出肌肉力量贡献的最大变化为2.3%。在偏心康复运动期间-康复期间的常见运动选择-与通用(对照)肌肉骨骼模型相比,顺应性肌腱模型显示出实质性差异,导致腓肠肌内侧(-3.5%)和腓肠肌外侧(-3.2%)的贡献减少,比目鱼肌的贡献增加(6.6%)。我们的研究结果强调了在肌肉骨骼模型中纳入肌腱顺应性以准确预测肱三头肌肌肉力量的必要性,尤其是在肌腱顺应性增加的个体中,如跟腱病患者。这些发现有助于更准确地预测肌肉力量,因此,个性化康复策略。
    The Achilles tendon exhibits anatomical variations in subtendon twist among individuals, and its compliance can change due to conditions like Achilles tendinopathy. However, current musculoskeletal models overlook these material and morphological variations. This study aimed to investigate the impact of altering Achilles subtendon insertion points and compliance on the triceps surae muscle forces, and therefore tendon loading, during dynamic exercises in one Achilles tendinopathy patient. First, subtendon insertion points were altered in the musculoskeletal model based on a subject-specific 3D freehand ultrasound model and for three types of subtendon twists: low, medium, and high. Second, tendon compliance was modeled based on experimental values, creating three musculoskeletal models: compliant, mean, and stiff. Results indicated that tendon compliance had a larger effect than tendon twist on triceps surae muscle forces. Altering subtendon insertion points to the three types of twist showed a maximal change of 2.3% in muscle force contribution compared to the no-twist model. During the eccentric rehabilitation exercise-a common exercise choice during rehabilitation-the compliant tendon model showed substantial differences compared to the generic (control) musculoskeletal model, resulting in decreased gastrocnemius medialis (-3.5%) and gastrocnemius lateralis (-3.2%) contributions and increased soleus contribution (+ 6.6%). Our study results highlight the necessity of incorporating tendon compliance in musculoskeletal models to accurately predict triceps surae muscle forces, especially in individuals with increased tendon compliance, such as patients with Achilles tendinopathy. Such findings contribute to more accurate predictions of muscle forces and hence, personalized rehabilitation strategies.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    目标:跟腱,人体最大最强壮的肌腱,经常因过度使用而受伤;这种情况被称为跟腱病(AT)。它是脚跟骨和小腿肌肉之间的纽带,是运动所必需的,比如走路,冲刺,和跳跃。提供的证据支持Graston技术和Alfredson方案减轻疼痛,改善功能和小腿肌肉力量的功效。这项研究的目的是比较Graston技术与Alfredson方案在AT患者中的疗效。方法和数据收集:在获得拉瓦尔品第医科大学伦理审查委员会的批准后,所有符合纳入标准的患者分为两组,A和B,通过使用MicrosoftExcel生成随机标识号进行分配。A组包括接受Graston技术作为Alfredson方案(12周小腿肌肉偏心运动)常规治疗的患者,而B组中的人则采用Graston技术进行脚后跟提升。偏心运动组中的个人遵循基于Alfredson方法的12周偏心运动计划,用于腿部肌肉。锻炼需要一天做两次,一周七天,持续12周。该计划包括两个练习:第一个练习膝盖伸直以锻炼腓肠肌,第二个练习膝盖弯曲以锻炼比目鱼肌。在受影响的肢体上每天两次完成三组15次重复,每次运动无休息间隔,以改善功能。
    结果:结果表明,Alfredson方案和Graston技术在治疗AT症状方面均有效。该研究将32名参与者分为两组,他们接受了4周的治疗。衡量改善的主要方法是称为Villalta-Scanlon跟腱炎指数评分的评分。在这两组中,这些评分显示出显著改善(p值小于0.001,这意味着结果具有非常显著的统计学意义).对于A组(接受Alfredson协议的人),治疗前Villalta-Scanlon跟腱炎指数平均评分为29.25.该评分在治疗中期增加至31.25,在治疗完整四周后增加至34.38。B组(接受Graston技术)的平均Villalta-Scanlon跟腱炎指数得分为22.94。在整个治疗过程中,他们的分数也有所增加,治疗中期达到34.94,四周后达到42.88。这些发现提供了两种治疗方法都可以改善AT症状的证据。根据治疗后较高的平均Villalta-Scanlon跟腱炎指数评分,有一些建议认为Graston技术可能更有效。
    结论:Graston技术显示了有希望的结果,特别是在治疗中和治疗后阶段,与Alfredson方案相比,表明其在AT治疗中的潜在疗效。
    OBJECTIVE: The Achilles tendon, the largest and strongest tendon in the human body, is frequently injured by overuse; this condition is known as Achilles tendinopathy (AT). It serves as a link between the heel bone and the calf muscles and is necessary for motions, such as walking, sprinting, and jumping. Evidence is presented to support the efficacy of the Graston technique and Alfredson protocol for pain reduction and improvement of function and calf muscle strength. The objective of this study is to compare the efficacy of the Graston technique versus the Alfredson protocol in patients with AT. Methods and data collection: After obtaining approval from the ethical review board of the Rawalpindi Medical University, all patients fulfilling the inclusion criteria are divided into two groups, A and B, by generating random identity numbers using Microsoft Excel for allocation. Group A comprises patients who undergo treatment with the Graston technique as conventional therapy with Alfredson protocol (12-week calf muscle eccentric exercises), while those in group B follow a Graston technique with sole heel lift. Individuals in the eccentric exercises group follow an Alfredson method-based 12-week eccentric exercise plan for their leg muscles. The workouts need to be done twice a day, seven days a week for 12 weeks. The plan includes two exercises: the first done with the knee straightened to work the gastrocnemius and the second done with the knee bent to work the soleus. Three sets of 15 repetitions with no rest interval for each exercise are completed twice a day on the affected limb to yield functional improvement.
    RESULTS: The results showed that both the Alfredson protocol and the Graston technique were effective in managing AT symptoms. The study involved dividing 32 participants into two groups who received either treatment for four weeks. The main way to measure improvement was a score called the Villalta-Scanlon Achilles Tendonitis Index score. In both groups, these scores showed significant improvement (with a p-value less than 0.001, which means that the results are very statistically significant). For Group A (who received the Alfredson protocol), the average Villalta-Scanlon Achilles Tendonitis Index score before treatment was 29.25. This score increased to 31.25 at mid-treatment and 34.38 after the full four weeks of treatment. Group B (who received the Graston technique) started with an average Villalta-Scanlon Achilles Tendonitis Index score of 22.94. Their scores also increased throughout the treatment, reaching 34.94 at mid-treatment and 42.88 after four weeks. These findings provide evidence that both treatments can improve AT symptoms, with some suggestions that the Graston technique might be even more effective based on the higher average Villalta-Scanlon Achilles Tendonitis Index scores after treatment.
    CONCLUSIONS: The Graston technique shows promising results, particularly in the mid- and post-treatment phases, indicating its potential efficacy in comparison to the Alfredson protocol in the treatment of AT.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    跑步大师在跑步社区中所占的比例越来越高。跑步者最显著的肌肉骨骼变化发生在50岁以后,除了损伤率和类型的变化,最常见的是跟腱病(AT)。先前的证据表明,在跑步的推进阶段,AT的危险因素与集中在臀部和脚踝的年龄相关变化之间存在相似性。这项研究的目的是研究大师跑步者与AT的生物力学和峰值扭矩关联。包括32名年龄在50岁以上的AT(60.31±8.37,n=16)和无AT(59.94±4.95n=16)的大师跑步者。使用3D运动捕获和测力板评估跑步生物力学。电机驱动的测功机用于评估等速峰值扭矩产生。有和没有AT的大师级跑步者在跑步生物力学方面没有发现显着差异。发现具有AT的大师级跑步者的髋关节峰值等速扭矩产生明显较少,但在踝关节屈峰值等速扭矩产生方面没有显著差异。具有AT的大师级跑步者可能能够在次最大的跑步努力中适应他们的跑步生物力学和肌肉扭矩产生。
    与健康的大师赛运动员相比,在亚最大努力期间的站立阶段,跟腱病变的大师赛运动员没有表现出峰值髋关节伸展时刻的差异。与健康的主跑步者相比,患有跟腱肌腱病的大师赛跑步者在次最大努力的站立阶段中没有表现出踝关节的最大屈时刻的差异。跟腱病变的大师赛运动员与健康的大师赛运动员相比,没有表现出峰值踝屈同心或偏心等速扭矩的差异。跟腱病变的大师赛运动员与健康的大师赛运动员相比,在峰值髋关节伸展同心和偏心等速扭矩方面存在差异。
    Masters runners are an increasing proportion of the running community. The most significant musculoskeletal changes in runners occur after the age of 50 in addition to changes in injury rates and types, the most common being Achilles tendinopathy (AT). Previous evidence has suggested similarities between risk factors for AT and age-related changes that are focused at the hip and the ankle during the propulsive stage of running. The purpose of this study was to investigate biomechanical and peak torque association to AT in masters runners. Thirty-two masters runners over age 50 with AT (60.31 ± 8.37, n = 16) and without (59.94 ± 4.95 n = 16) were included. 3D motion capture and force plates were used to assess running biomechanics. A motor-driven dynamometer was used to assess isokinetic peak torque production. No significant differences in running biomechanics were found between masters runners with and without AT. Hip peak isokinetic torque production was found to be significantly less in masters runners with AT, but no significant differences in ankle plantarflexion peak isokinetic torque production were found. Masters runners with AT may be able to adapt their running biomechanics and muscular torque production during submaximal running efforts.
    Masters runners with Achilles tendinopathy do not demonstrate differences in peak hip extension moments during the stance phase of running during submaximal efforts compared to healthy masters runners.Masters runners with Achilles tendinopathy do not demonstrate differences in peak ankle plantarflexion moments during the stance phase of running during submaximal efforts compared to healthy masters runners.Masters runners with Achilles tendinopathy do not demonstrate differences in peak ankle plantarflexion concentric or eccentric isokinetic torque compared to healthy masters runners.Masters runners with Achilles tendinopathy demonstrate differences in peak hip extension concentric and eccentric isokinetic torque compared to healthy masters runners.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    氟喹诺酮类药物摄入与跟腱病(AT)或跟腱断裂(ATR)之间的关联已被广泛记录。然而,目前尚不清楚不同的分子是否对这些并发症有相同的影响。这项研究的目的是记录大多数规定的氟喹诺酮类药物分子的跟腱并发症。
    在Pubmed,科克伦,Embase,和截至2023年4月的WebofScience数据库。纳入标准:任何水平的证据的研究,用英语写的,记录服用氟喹诺酮类药物后AT/ATR的患病率,并对每种分子的结果进行分层。DownsandBlack的“质量测量清单”用于评估偏差的风险。
    纳入了12项研究,调查了439,299名患者(59.7%的女性,40.3%男性,平均年龄:53.0±15.6岁)。左氧氟沙星的AT/ATR的预期风险为0.17%(95%CI:0.15-0.19,标准误差(s.e.):0.24),环丙沙星为0.17%(95%CI:0.16-0.19,s.e.:0.20),氧氟沙星为1.40%(95%CI:0.88-2.03,s.e.:2.51),其他分子为0.31%(95%CI:0.23-0.40,s.e.:0.77)。组间比较证明氧氟沙星组的AT/ATR率显著较高(每次比较P<0.0001)。左氧氟沙星和环丙沙星显示出相同的风险(P=n.s.)。纳入的研究总体质量较好。
    氧氟沙星在成人人群中表现出明显更高的AT/ATR并发症发生率,而与所有其他分子相比,左氧氟沙星和环丙沙星显示出更安全的特征。需要更多的数据来确定影响肌肉骨骼并发症风险的其他患者和治疗相关因素。
    UNASSIGNED: The association between fluoroquinolone intake and Achilles tendinopathy (AT) or Achilles tendon rupture (ATR) is widely documented. However, it is not clear whether different molecules have the same effect on these complications. The purpose of this study was to document Achilles tendon complications for the most prescribed fluoroquinolones molecules.
    UNASSIGNED: A literature search was performed on Pubmed, Cochrane, Embase, and Web of Science databases up to April 2023. Inclusion criteria: studies of any level of evidence, written in English, documenting the prevalence of AT/ATR after fluoroquinolone consumption and stratifying the results for each type of molecule. The Downs and Black\'s \'Checklist for Measuring Quality\' was used to evaluate the risk of bias.
    UNASSIGNED: Twelve studies investigating 439,299 patients were included (59.7% women, 40.3% men, mean age: 53.0 ± 15.6 years). The expected risk of AT/ATR was 0.17% (95% CI: 0.15-0.19, standard error (s.e.): 0.24) for levofloxacin, 0.17% (95% CI: 0.16-0.19, s.e.: 0.20) for ciprofloxacin, 1.40% (95% CI: 0.88-2.03, s.e.: 2.51) for ofloxacin, and 0.31% (95% CI: 0.23-0.40, s.e.: 0.77) for the other molecules. The comparison between groups documented a significantly higher AT/ATR rate in the ofloxacin group (P < 0.0001 for each comparison). Levofloxacin and ciprofloxacin showed the same risk (P = n.s.). The included studies showed an overall good quality.
    UNASSIGNED: Ofloxacin demonstrated a significantly higher rate of AT/ATR complications in the adult population, while levofloxacin and ciprofloxacin showed a safer profile compared to all the other molecules. More data are needed to identify other patient and treatment-related factors influencing the risk of musculoskeletal complications.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    目的:跟腱由三个具有相对滑动能力的肌腱下组成。由于最佳的腱内滑动被认为可以减少肌腱中的整体应力,滑动行为的改变可能在跟腱病的发展中起作用。这项研究的目的是研究无症状对照组和跟腱病患者在等距收缩期间跟腱内滑动的差异,以及改变水平脚位置对两组跟腱内滑动的影响。
    方法:29名参与者(13名跟腱病和16名对照)以其最大自愿收缩(MVC)的60%进行了等距的前屈收缩,在脚趾中性,在脚趾中立的30%MVC下,脚趾,以及记录超声图像的脚趾位置。肌腱内滑动被估计为浅到中和中到深的相对位移。
    结果:跟腱病变患者的腱内滑动低于无症状对照组。关于两组的水平脚位置,与脚趾中立和脚趾外脚位置相比,脚趾外脚位置导致滑动增加。
    结论:我们提供的证据表明,跟腱病患者的腱内滑动低于无症状对照组。由于肌腱内滑动是跟腱的生理特征,足外位置有望增加跟腱病患者的滑动并促进健康的肌腱行为。未来的研究应该调查在康复计划中实施这种外部足部位置是否会刺激跟腱内的滑动并改善临床结果。
    OBJECTIVE: The Achilles tendon consists of three subtendons with the ability to slide relative to each other. As optimal intratendinous sliding is thought to reduce the overall stress in the tendon, alterations in sliding behavior could potentially play a role in the development of Achilles tendinopathy. The aims of this study were to investigate the difference in intratendinous sliding within the Achilles tendon during isometric contractions between asymptomatic controls and patients with Achilles tendinopathy and the effect of changing the horizontal foot position on intratendinous sliding in both groups.
    METHODS: Twenty-nine participants (13 Achilles tendinopathy and 16 controls) performed isometric plantarflexion contractions at 60% of their maximal voluntary contraction (MVC), in toes-neutral, and at 30% MVC in toes-neutral, toes-in, and toes-out positions during which ultrasound images were recorded. Intratendinous sliding was estimated as the superficial-to-middle and middle-to-deep relative displacement.
    RESULTS: Patients with Achilles tendinopathy present lower intratendinous sliding than asymptomatic controls. Regarding the horizontal foot position in both groups, the toes-out foot position resulted in increased sliding compared with both toes-neutral and toes-out foot position.
    CONCLUSIONS: We provided evidence that patients with Achilles tendinopathy show lower intratendinous sliding than asymptomatic controls. Since intratendinous sliding is a physiological feature of the Achilles tendon, the external foot position holds promise to increase sliding in patients with Achilles tendinopathy and promote healthy tendon behavior. Future research should investigate if implementing this external foot position in rehabilitation programs stimulates sliding within the Achilles tendon and improves clinical outcome.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    背景:由Taylor(ZO)改良的Zadek截骨术是一种通过减少足跟突出和抬高跟腱插入来治疗插入型跟腱病(IAT)的手术技术。本研究旨在使用带有特定软件的虚拟手术仿真分析ZO后IAT的生物力学后果。
    方法:回顾性分析20例IAT患者的计算机断层扫描(WBCT)扫描。使用Disior的BonelogicTM软件,从WBCT图像创建3D模型。虚拟ZO在这些模型上执行,并在虚拟截骨前后测量各种生物力学参数。
    结果:虚拟ZO显示出跟骨长度平均值的显着统计学差异(p<0.001),FowlerPhilips角度(p<0.001),跟骨螺距(p<0.001),和矢状角(p<0.001)。
    结论:虚拟ZO分析表明,该程序可以减小FowlerPhilips角度,缩短跟骨,特别修改矢状对齐。
    方法:IV;病例系列。
    BACKGROUND: The Zadek osteotomy modified by Taylor (ZO) is a surgical technique used to treat insertional Achilles tendinopathy (IAT) by reducing the heel\'s prominence and elevating the Achilles tendon insertion. This study aims to analyze the biomechanical consequences of IAT after ZO using a virtual surgical simulation with a specific software.
    METHODS: A retrospective analysis of 20 wtbearing computed tomography (WBCT) scans of IAT patients was conducted. Using Disior\'s BonelogicTM software, 3D models were created from WBCT images. Virtual ZO was performed on these models, and various biomechanical parameters were measured before and after the virtual osteotomy.
    RESULTS: The virtual ZO showed significant statistical differences in the average of the calcaneal length (p < 0.001), Fowler Philips angle (p < 0.001), calcaneal pitch (p < 0.001), and the sagittal talocalcaneal angle (p < 0.001).
    CONCLUSIONS: The virtual ZO analysis suggests that this procedure can decrease the Fowler Philips angle, shorten the calcaneus, modifying specifically the sagittal alignment.
    METHODS: IV; case series.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    由于尚未建立通用的临床实践指南,因此对于患者和提供护理的医疗团队来说,肌腱病仍然是一个挑战。总的来说,肌腱病的典型特征是延长,局部化,活动相关的疼痛与组织组成异常,cellularity,以及可以在成像或组织学上观察到的微观结构。在下肢,影响跟腱和髌骨肌腱的肌腱病变是最常见的,在运动人群中发病率很高。由于在病理生理学和临床表现上缺乏普遍共识,因此一致的诊断和管理受到挑战。目前的管理主要基于症状缓解,通常包括非甾体抗炎药等药物,注射疗法,和锻炼方案,通常强调受影响结构的渐进偏心载荷。实施肌腱干/祖细胞(TSPCs)的知识并评估其增强肌腱修复的潜力可以填补这方面的重要空白。在目前的体内试验研究中,我们已经描述了跟腱和髌骨肌腱病模型中肌腱损伤后不久发生的结构和细胞改变。受伤时,CD146+TSPCs从束间肌腱基质中募集到邻近区域,而观察到的M1巨噬细胞极化的减少与原位修复性CD146TSPCs的丰度增加有关。在体外环境中也证明了TSPCs对巨噬细胞的强大免疫调节作用,其中TSPCs可以有效地使M1巨噬细胞极化为抗炎治疗M2表型。虽然是初步的,我们的研究结果表明,CD146+TSPCs是一种关键表型,可以在肌腱病的靶向再生疗法的开发中进行探索.
    Tendinopathies continue to be a challenge for both patients and the medical teams providing care as no universal clinical practice guidelines have been established. In general, tendinopathies are typically characterized by prolonged, localized, activity-related pain with abnormalities in tissue composition, cellularity, and microstructure that may be observed on imaging or histology. In the lower limb, tendinopathies affecting the Achilles and the patellar tendons are the most common, showing a high incidence in athletic populations. Consistent diagnosis and management have been challenged by a lack of universal consensus on the pathophysiology and clinical presentation. Current management is primarily based on symptom relief and often consists of medications such as non-steroidal anti-inflammatories, injectable therapies, and exercise regimens that typically emphasize progressive eccentric loading of the affected structures. Implementing the knowledge of tendon stem/progenitor cells (TSPCs) and assessing their potential in enhancing tendon repair could fill an important gap in this regard. In the present pilot in vivo study, we have characterized the structural and cellular alterations that occur soon after tendon insult in models of both Achilles and patellar tendinopathy. Upon injury, CD146+ TSPCs are recruited from the interfascicular tendon matrix to the vicinity of the paratenon, whereas the observed reduction in M1 macrophage polarization is related to a greater abundance of reparative CD146+ TSPCs in situ. The robust TSPCs\' immunomodulatory effects on macrophages were also demonstrated in in vitro settings where TSPCs can effectively polarize M1 macrophages towards an anti-inflammatory therapeutic M2 phenotype. Although preliminary, our findings suggest CD146+ TSPCs as a key phenotype that could be explored in the development of targeted regenerative therapies for tendinopathies.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    本研究的目的是评估孤立的腓肠肌松解术在跟腱病治疗中的应用。主要结果是患者报告的疼痛结果的变化。次要结果包括患者报告的足部和踝关节功能的变化,踝关节的活动范围和力量,患者满意度和手术并发症发生率。
    对采用孤立腓肠肌松解术治疗跟腱病的患者进行了系统评价。随机对照试验,队列研究,病例对照研究和病例系列符合资格,并从以下数据库中确定:MEDLINE和EMBASE.
    孤立的腓肠肌释放可改善患者报告的疼痛和足踝功能的结果评分。踝关节活动范围增加,但踝关节力量减少。患者报告的总体满意度很高。最常见的手术并发症是腓肠神经损伤和伤口感染。
    孤立的腓肠肌松解术可以在疼痛和足踝功能方面提供持续且有临床意义的改善,同时踝关节力量降低。
    UNASSIGNED: The aim of this study is to evaluate the use of isolated gastrocnemius release in the treatment of Achilles tendinopathy. The primary outcome is the change in patient-reported pain outcomes. Secondary outcomes include the change in patient-reported foot and ankle function, ankle range of motion and strength, patient satisfaction and rate of surgical complications.
    UNASSIGNED: A systematic review was undertaken of studies involving patients treated with an isolated gastrocnemius release for Achilles tendinopathy. Randomised controlled trials, cohort studies, case-control studies and case series were eligible and identified from the following databases: MEDLINE and EMBASE.
    UNASSIGNED: Isolated gastrocnemius release results in improved patient-reported outcome scores for pain and foot and ankle function. There is an increase in ankle range of motion but a reduction in ankle strength. Patients report a high rate of overall satisfaction. The most common surgical complications are sural nerve injury and wound infection.
    UNASSIGNED: Isolated gastrocnemius release may offer maintained and clinically meaningful improvements in pain and foot and ankle function with an associated reduction in ankle strength.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

公众号