Abdominal Tuberculosis

腹部结核
  • 文章类型: Case Reports
    腹部结核(TB)仍然是全球重大的健康问题。特别是在北非和摩洛哥等地方性高的地区。尽管诊断方式有了进步,腹部结核的非特异性表现对及时诊断和治疗提出了挑战.这里,我们报告了一例来自摩洛哥的年轻人的腹部结核病,表现为急性腹痛和败血症的迹象。放射学检查显示提示肠穿孔并发腹膜结核的特征。紧急剖腹手术证实了诊断,然而,患者在术后死于晚期脓毒症。该病例强调了腹部结核诊断和治疗的复杂性,需要高度怀疑和多学科合作。随着外科技术的发展和持续的研究工作,优化早期发现和治疗腹部结核病的策略仍然势在必行,特别是在流行地区。
    Abdominal tuberculosis (TB) remains a significant health concern globally, particularly in regions with high endemicity such as North Africa and Morocco. Despite advances in diagnostic modalities, the nonspecific presentation of abdominal TB poses challenges for timely diagnosis and management. Here, we report a case of abdominal TB in a critically state of a young man from Morocco, presenting with acute abdominal pain and signs of sepsis. Radiological investigations revealed features suggestive of intestinal perforation complicating peritoneal TB. Urgent laparotomy confirmed the diagnosis, yet the patient succumbed to advanced sepsis postoperatively. This case underscores the complexity of abdominal TB diagnosis and management, necessitating a high index of suspicion and multidisciplinary collaboration. With evolving surgical techniques and ongoing research efforts, optimizing strategies for early detection and treatment of abdominal TB remains imperative, particularly in endemic regions.
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  • 文章类型: Case Reports
    结肠癌和结核病(TB)的共存代表了一种罕见且复杂的临床情况。它在诊断和管理方面都提出了重大挑战。这种共存的临床预测具有挑战性,因为这两种疾病的临床特征通常相似。同样,放射学不是决定性的,因为癌症和结核病的影像发现存在显著重叠.最终的诊断依赖于恶性肿瘤和TB的组织病理学证据。这里,我们报道了一例58岁女性慢性腹痛的病例.计算机断层扫描显示盲肠中存在肿块。通过结肠镜检查获得的组织的组织病理学表明盲肠的TB和腺癌的特征。通过基于药筒的核酸扩增试验在组织中检测结核分枝杆菌。患者开始接受抗结核治疗。她接受了肿块的手术切除,并计划进行辅助化疗。
    The coexistence of carcinoma of the colon and tuberculosis (TB) represents a rare and intricate clinical scenario. It poses significant challenges in both diagnosis and management. Clinical prediction of this coexistence is challenging since the clinical features of these two conditions are often similar. Likewise, the radiology is not decisive because of the significant overlap in the image findings of carcinoma and TB. A conclusive diagnosis relies on histopathological evidence of both malignancy and TB. Here, we report a case of a 58-year-old female who presented with chronic abdominal pain. Computed tomography showed the presence of a mass in the cecum. Histopathology of tissue retrieved through colonoscopy was indicative of features of both TB and adenocarcinoma of the cecum. Mycobacterium tuberculosis was detected in the tissue by cartridge-based nucleic acid amplification test. The patient was initiated on antitubercular treatment. She underwent surgical resection of the mass and is planned for adjuvant chemotherapy.
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  • 文章类型: Journal Article
    背景:腹部结核以多种方式出现。除了具有高度的临床怀疑以诊断和开始治疗之外,还必须应用不同的测试模式。药物反应良好;然而,在对肠梗阻和穿孔等复杂表现进行手术治疗后,已经看到了发病率。在小儿年龄组中,很少有研究评估对不同治疗方案的反应并确定与腹部结核患儿预后较差相关的因素。
    方法:使用问卷评估单中心75例腹部结核患儿的患者记录,涵盖2007年至2021年的14年期间。人口统计特征,出现体征和症状,调查和治疗细节进行了研究。进行面对面或电话随访以确定治疗结果。
    结果:腹部结核发病率为7%,在所有结核病儿童中,平均年龄为10.1岁。67%的病例涉及肠系膜淋巴结,33%的病例涉及小肠。22名儿童需要手术。85%的儿童完成了治疗。小肠受累接受手术的可能性更高。在70名完全随访的儿童中,64例良好,6例儿童死于该疾病。年纪大了,小肠受累和手术与较高的死亡率独立相关.
    结论:肠道受累与更大的手术干预需求和更大的死亡率相关。青少年的结果较差。需要进一步的研究集中在这些单独的子组,以了解呈现的模式,死亡原因和预防。
    方法:第5级。
    BACKGROUND: Abdominal tuberculosis presents in a variety of ways. Different testing modalities must be applied in addition to having a high clinical suspicion to diagnose and initiate therapy. Medications have a good response; however, morbidity has been seen following surgical management of complicated presentations like intestinal obstruction and perforation. There is a paucity of studies in the pediatric age group which evaluate response to the different treatment regimen and identify factors associated with poorer outcomes in children with abdominal tuberculosis.
    METHODS: Patient records of 75 children with abdominal tuberculosis at a single center were evaluated using a questionnaire, covering a 14-year period from 2007 to 2021. Demographic features, presenting signs and symptoms, investigations and treatment details were studied. In- person or telephonic follow-up was conducted to identify treatment outcomes.
    RESULTS: Incidence of abdominal TB was 7%, of all TB children with a mean age of 10.1 years. Mesenteric lymph nodes were involved in 67% and small intestine in 33% cases. Surgery was required in 22 children. 85% children completed treatment. Small intestine involvement had higher probability of undergoing surgery. Of the 70 children with complete follow up, 64 were well and 6 children succumbed to the disease. Older age, small intestine involvement and surgery were independently associated with higher mortality.
    CONCLUSIONS: Intestinal involvement is associated with greater need for surgical intervention and greater mortality. Adolescents have poorer outcomes. Further studies are required focusing on these individual subgroups to understand the patterns of presentation, causes for mortality and prevention.
    METHODS: Level 5.
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  • 文章类型: Case Reports
    结核病(TB)仍然是一个重要的全球健康问题,每年全世界都有数百万人受到影响。肺外结核,特别涉及消化道和中枢神经系统,在诊断和治疗方面都存在独特的困难。我们报告了一例15岁的女孩,有肠结核病史,接受抗结核治疗,症状提示脑膜炎,伴随着腹痛和腹胀。我们最初怀疑是结核性脑膜炎,考虑到腹部结核,后来得到脑脊液分析的支持,该分析显示淋巴细胞占优势的细胞增多和抗酸杆菌染色阳性。同时,患者出现血流动力学不稳定和严重腹痛,在腹部的重复X射线上显示出隔膜下的空气,提示手术探查并发现多个回肠穿孔。组织病理学检查证实TB是穿孔的原因。该病例强调了并发结核性脑膜炎和肠结核穿孔的诊断和治疗复杂性。早期识别和跨学科管理对于最佳患者预后至关重要。
    Tuberculosis (TB) remains a significant global health concern, with millions affected worldwide each year. Extrapulmonary TB, particularly involving the digestive tract and central nervous system, poses distinctive difficulties in both diagnosis and treatment. We report a case involving a 15-year-old girl with a history of intestinal TB on anti-tuberculous therapy who presented with symptoms suggestive of meningitis, along with abdominal pain and distension. Our initial suspicion was tuberculous meningitis, considering the underlining abdominal TB, which was later supported by cerebrospinal fluid analysis showing lymphocytic-predominant pleocytosis and positive acid-fast bacilli staining. Concurrently, the patient developed hemodynamic instability and severe abdominal pain, which on repeat X-rays of the abdomen showed air under the diaphragms, prompting surgical exploration and revealing multiple ileal perforations. Histopathological examination confirmed TB as the cause of perforation. This case highlights the diagnostic and therapeutic complexities of concurrent tuberculous meningitis and intestinal TB perforation. Early recognition and interdisciplinary management are crucial for optimal patient outcomes.
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  • 文章类型: Case Reports
    该病例报告介绍了一名居住在澳大利亚的25岁女性的罕见腹膜结核(TB)与蠕虫感染并存的病例。强调腹部结核病带来的诊断挑战。尽管西方国家的结核病发病率较低,腹部结核由于其非特异性症状和其他腹部病理的潜在模仿,仍然是诊断难题.该病例强调了将结核病视为无法解释的腹部症状的鉴别诊断的重要性。特别是在有旅行史或以前居住在高流行地区的个人中。涉及传染病专家的多学科方法,放射科医生,和外科医生是必不可少的全面管理。一旦确诊,建议立即开始抗结核治疗。
    This case report presents a rare case of peritoneal tuberculosis (TB) coexisting with a helminthic infection in a 25-year-old female residing in Australia, highlighting the diagnostic challenges posed by abdominal TB. Despite the low incidence of TB in Western countries, abdominal TB remains a diagnostic dilemma due to its nonspecific symptoms and potential mimicry of other abdominal pathologies. The case highlights the importance of considering TB as a differential diagnosis of unexplained abdominal symptoms, particularly in individuals with a history of travel or previous residence in high-endemic regions. A multidisciplinary approach involving infectious disease specialists, radiologists, and surgeons is essential for comprehensive management. Prompt initiation of anti-TB therapy is recommended once diagnosis is confirmed.
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  • 文章类型: Case Reports
    腹部结核(TB)可以影响胃肠道的任何部分,实体器官,腹膜,或淋巴结。由于缺乏特定的临床体征和症状以及对其他腹内疾病的模仿,腹部结核病的诊断通常会延迟。我们介绍了一例胃十二指肠结核,胰周淋巴结受累,表现为胃出口梗阻,并采用抗结核药物保守治疗。
    Abdominal tuberculosis (TB) can affect any part of the gastrointestinal tract, solid organs, peritoneum, or lymph nodes. The diagnosis of abdominal TB is usually delayed due to a lack of specific clinical signs and symptoms and the mimicking of other intra-abdominal diseases. We present a case of gastroduodenal tuberculosis with peripancreatic lymph node involvement presented as a gastric outlet obstruction that was treated conservatively with anti-tuberculosis medications.
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  • 文章类型: Case Reports
    腹水表现为各种疾病的临床表现,腹膜液中嗜酸性粒细胞水平升高是嗜酸性粒细胞腹水的特征,这是一种极其罕见的疾病。嗜酸细胞性胃肠炎是引起腹水的少见原因之一。如果没有彻底调查,有结核病史的年轻女性的腹水复发可能错误地归因于流行国家的结核病复发。在我们的病例中,腹水的病因被正确地确定为嗜酸性粒细胞性腹水的浆膜下形式。在这种情况下,口服皮质类固醇是治疗的主要手段。嗜酸细胞性胃肠炎是一种罕见的疾病,但是彻底的检查和强烈的临床怀疑可能有助于成功诊断和治疗此类病例。
    Ascites appear as a clinical manifestation of various disorders, and the presence of raised levels of eosinophils in the peritoneal fluid characterizes eosinophilic ascites, which is an extremely rare disorder. Eosinophilic gastroenteritis is one of the uncommon causes of ascites. If not investigated thoroughly, ascites recurrence in a young female with a history of tuberculosis may be wrongly attributed to tuberculosis recurrence in an endemic country. The etiology of ascites in our case was correctly identified as the subserosal form of eosinophilic ascites. Oral corticosteroids form the mainstay of treatment in such cases. Eosinophilic gastroenteritis is a rare disease, but a thorough workup and a strong clinical suspicion may help in the successful diagnosis and treatment of such cases.
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  • 文章类型: Case Reports
    结核病(TB),由结核分枝杆菌引起,仍然是全球健康问题,发病率和死亡率很高。肺外结核(EPTB),影响肺部以外的各种器官,由于其多样化的临床和放射学表现,提出了诊断挑战。在这里,我们描述了一个患有严重下腹痛的中年妇女的病例,呕吐,晚上发烧,和其他症状。临床和放射学检查显示盆腔脓肿和腹膜炎。探究性腹腔镜检查未发现腹腔粘连,含有脓液的脓肿腔,活检证实结核分枝杆菌感染。进行了术后肺科会诊,包括痰培养物用于结核病检测,患者开始服用抗结核药物。该病例突出了诊断腹部结核病的复杂性和综合诊断方法的重要性。
    Tuberculosis (TB), caused by Mycobacterium tuberculosis, continues to be a global health concern with high morbidity and mortality rates. Extrapulmonary TB (EPTB), which affects various organs beyond the lungs, presents a diagnostic challenge due to its diverse clinical and radiological manifestations. Herein, we describe the case of a middle-aged woman with severe lower abdominal pain, vomiting, night fevers, and other symptoms. Clinical and radiological examinations revealed pelvic abscesses and peritonitis. Exploratory laparoscopy uncovered intraabdominal adhesions, a pus-containing abscess cavities, and biopsies confirmed Mycobacterium tuberculosis infection. Post-operative pulmonology consultations comprising sputum cultures for TB detection were conducted, and the patient was started on anti-tuberculosis medications. This case highlights the complexity of diagnosing abdominal TB and the importance of a comprehensive diagnostic approach.
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  • 文章类型: Journal Article
    背景:在包括印度在内的发展中国家,以急性外科急症表现的腹部结核仍然是一个主要问题。作为一种表现多样的惰性疾病,有必要描述流行病学,该疾病的临床病理性质。因此,本系列的目的是描述我们在处理急性外科急症腹部结核方面的机构经验,概述流行病学,管理方面,并分析了我国人口不良结局的危险因素。
    方法:这是2021年1月至2022年1月在印度东部一家三级护理医院接受腹部结核手术的一系列描述性患者,表现为急性外科急诊。所有连续的肠梗阻或腹膜炎患者均接受剖腹手术,术中和组织病理学发现提示结核。
    结果:共有30例急性腹部结核患者被纳入研究。56.7%的患者为男性;出现的平均年龄为43岁,年轻至中年组的大多数患者。大多数(80%)患者来自农村地区,获得医疗保健的机会有限。一名患者与HIV合并感染。5名患者患有糖尿病,6名患者患有高血压。73.3%的患者患有原发性肠结核。大多数(76.7%)患者出现急性肠梗阻。所有患者均表现为一致的腹痛。40%的患者贫血,70%的患者血清白蛋白水平较低。最常见的发病部位是盲肠区(73.3%),病理为狭窄。以端到端吻合术为节段切除是最常见的手术(46.7%)。26.7%的患者有不良的术后并发症,手术部位感染(SSI)占23.3%。我们系列的死亡率为6.7%。虽然同时存在SSI,合并症与死亡率增加相关,结果无统计学意义(p=0.08).16例患者失访。
    结论:即使在21世纪,以急腹症表现的腹部结核仍在挑战外科医生。发展中国家的大多数晚期出现各种并发症。为了及时诊断以降低疾病的死亡率和发病率,需要高度的临床怀疑指数。
    BACKGROUND: Abdominal tuberculosis presenting as acute surgical emergency continues to be a major issue in developing countries including India. Being an indolent disease with varied presentation, there is a need to describe the epidemiology, clinicopathological nature of the disease. Hence, this series was conducted with the aim of describing our institutional experience in the management of abdominal tuberculosis presenting as acute surgical emergency, outlining the epidemiology, management aspects and the analysis of risk factors for poor outcome in our population.
    METHODS: This was a descriptive series of patients operated for abdominal tuberculosis presenting as acute surgical emergency at a tertiary care hospital in Eastern India from January 2021 to January 2022. All consecutive patients presenting with intestinal obstruction or peritonitis who underwent laparotomy with intra operative and histopathological finding suggestive of tuberculosis were taken for the study.
    RESULTS: A total of 30 patients with acute abdominal tuberculosis were included in the study. 56.7% of patients were males; the mean age of presentation was 43 years with majority of patients in the younger to middle age groups. Most (80%) patients were from rural areas with limited access to healthcare. One patient had co-infection with HIV. Five patients had diabetes and six patients had hypertension as co-morbidities. 73.3% of patients had primary intestinal tuberculosis. Majority (76.7%) presented with acute intestinal obstruction. All patients had colicky abdominal pain as a consistent feature. 40% of patients were anaemic and 70% had low serum albumin levels. The most common site of affection was Ileo-cecal region (73.3%) with stricture as the pathology. Segmental resection with end to end anastomosis was the most common procedure performed (46.7%). 26.7% of patients had an adverse post operative complication, and 23.3% had surgical site infection (SSI). The mortality rate in our series was 6.7%. Although coexisting SSI, co-morbidities were associated with increased mortality, it was not found to be statistically significant (p = 0.08). 16 patients were lost to follow up.
    CONCLUSIONS: Abdominal tuberculosis presenting as acute abdomen continues to challenge surgeons even in the 21st century. Majority in the developing countries present late with varied complications. A high index of clinical suspicion is required for timely diagnosis to reduce the mortality and morbidity of the disease.
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  • 文章类型: Case Reports
    Chilaiditi综合征是结肠的肝膈插入。它可能是由肠道的任何病理引起的,肝,和膈肌因素。任何解剖变异或功能异常均可增加Chilaiditi综合征的发展。它通常是无症状的,在放射学研究中被发现。只要不出现任何并发症,就可以保守治疗。此例Chilaiditi综合征与乙状结肠扭转和表面多发结节有关。一名35岁的男性患者因体重减轻而向门诊部(OPD)就诊,双侧侧腹疼痛,腹胀,食欲下降,呕吐,和腹泻。CT扫描显示结肠环明显扩张,伴有乙状结肠扭转和Chilaiditi征。做了剖腹手术,乙状结肠扭转缓解了,对结节进行了活检以进行组织病理学检查,做了结肠造口术.活检结果为腹部结核。结肠造口术后来被逆转。Chilaiditi综合征通常通过手术治疗,因为它与胃肠道的其他并发症有关。以前的研究表明,通过结肠切除和原发性吻合来处理病例;然而,有一例报告由于吻合口漏导致死亡.在这篇文章中,我们介绍了一例与乙状结肠扭转和腹部结核相关的Chilaiditi综合征,如活检所见,通过结肠造口术进行手术管理,然后在随访时进行结肠造口术逆转。
    Chilaiditi\'s syndrome is the hepatodiaphragmatic interposition of the colon. It can be caused by any pathology of intestinal, hepatic, and diaphragmatic factors. Any anatomic variations or functional abnormalities can increase the development of Chilaiditi\'s syndrome. It is usually asymptomatic and is found indecently in radiological studies. It is treated conservatively as long as any complications do not arise. This case of Chilaiditi\'s syndrome was associated with sigmoid volvulus and multiple tubercles on its surface. A 35-year-old male patient presented to the outpatient department (OPD) with complaints of weight loss, bilateral flank pain, abdominal distention, decreased appetite, vomiting, and diarrhea. CT scan showed a grossly distended loop of the colon with sigmoid volvulus and Chilaiditi\'s sign. A laparotomy was done, sigmoid volvulus was relieved, a biopsy of tubercles was taken for histopathology, and a colostomy was done. The biopsy result showed abdominal tuberculosis. The colostomy was later reversed. Chilaiditi\'s syndrome is usually treated surgically because it is associated with other complications in the gastrointestinal tract. Previous studies showed the management of cases by colonic resection with primary anastomosis; however, there was one case that reported mortality due to an anastomosis leak. In this article, we present a case of Chilaiditi\'s syndrome associated with sigmoid volvulus and abdominal tuberculosis as seen on biopsy, which was managed surgically by colostomy followed by colostomy reversal on follow-up.
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