粘土矿物,如埃洛石纳米管(HNTs),大量可用的绿色纳米材料,在生物医学应用如药物递送方面表现出显著优势,抗菌和抗菌药物,组织工程或再生,等。由于介孔结构和高吸收性,HNT作为纳米载体在药物递送应用中表现出巨大的潜力。硫酸处理提高了HNT的表面积,从而通过扩大其腔空间/内径来提高其载药能力。在目前的调查中,基于支持酸处理后药物加载功效的文献,进行双重处理以使HNTs表面功能化。首先,使用硫酸蚀刻和官能化HNT。酸官能化的HNT经历使用(3-氨基丙基)三乙氧基硅烷(APTES)的另一处理,以使药物分子与HNT表面更好地相互作用,从而有效地加载药物。Augmentin,青霉素组的潜在药物分子,用于HNTs加载,以及它们的抗菌特性,细胞毒性,和累积药物释放(%)进行评估。不同的表征技术,如X射线衍射仪(XRD)和傅里叶变换红外(FT-IR),确认Augmentin加载到APTES@酸性HNT中。TEM图像证实了药物分子与HNT的有效负载。药物包封率显示40.89%,如通过热重分析(TGA)所证实的。此外,Augmentin负载的APTES@酸性HNTs对大肠杆菌和金黄色葡萄球菌表现出良好的抗菌性能和低细胞毒性,如MTT测定所证实。药物释放研究证实了Augmentin从APTES@酸性HNT的可持续释放。因此,经处理的HNT可以被认为是有效递送Augmentin并促进增强的治疗益处的潜在纳米载体。
Clay minerals such as Halloysite nanotubes (HNTs), abundantly available green nanomaterial, exhibit a significant advantage in biomedical applications such as drug delivery, antibacterial and antimicrobials, tissue engineering or regeneration, etc. Because of the mesoporous structure and high absorbability, HNTs exhibit great potential as a nanocarrier in drug delivery applications. The sulfuric acid treatment enhances the surface area of the HNTs and thereby improves their drug-loading capacity by enlarging their lumen space/inner diameter. In the present investigation, based on the literature that supports the efficacy of drug loading after acid treatment, a dual treatment was performed to functionalize the HNTs surface. First, the HNTs were etched and functionalized using sulfuric acid. The acid-functionalized HNTs underwent another treatment using (3-aminopropyl) triethoxysilane (
APTES) to better interact the drug molecules with the HNTs surfaces for efficient drug loading. Augmentin, a potential drug molecule of the penicillin group, was used for HNTs loading, and their antibacterial properties, cytotoxicity, and cumulative drug release (%) were evaluated. Different characterization techniques, such as X-ray diffractometer (XRD) and Fourier Transform Infra-Red (FT-IR), confirm the loading of Augmentin to the
APTES@Acid HNTs. TEM images confirm the effective loading of the drug molecule with the HNTs. The drug encapsulation efficiency shows 40.89%, as confirmed by the Thermogravimetric Analysis (TGA). Also, the Augmentin-loaded
APTES@Acid HNTs exhibited good antibacterial properties against E. coli and S. aureus and low cytotoxicity, as confirmed by the MTT assay. The drug release studies confirmed the sustainable release of Augmentin from the
APTES@Acid HNTs. Hence, the treated HNTs can be considered as a potential nanocarrier for effectively delivering Augmentin and promoting enhanced therapeutic benefits.