急性早幼粒细胞白血病(APL)是一种具有潜在致命并发症的医疗紧急情况。APL主要来自染色体易位(t(15;17)(q22;q21)),导致PML-RARA融合基因与三种可能的同种型的形成。本研究旨在调查伊朗APL患者的特点,PML-RARA亚型的分布,和生存分析。
■我们纳入了145名连续符合条件的患者。数据是通过存档文件和电话查询收集的,在同意之后。随后,我们使用SPSS软件26.0版分析数据。
■我们检查了75名男性和70名女性,平均年龄34岁(范围:2-78岁)。除了t(15;17)(q22;q21),其他染色体异常占45.6%。bcr1和bcr3亚型的患病率分别为73%和27%,分别。bcr3与较高的白细胞(WBC)计数相关,额外的染色体异常,和更快的完全血液学反应(CHR)。约36%的患者出现早期死亡。平均总生存时间为73.5个月,所有患者的120个月生存率为53.8%,达到CHR的患者为83.9%。单变量分析确定老年,复发,降低血小板(PLT)计数,更高的白细胞计数,和白细胞增多作为生存危险因素。然而,在多变量分析中,只有高龄和较高的白细胞计数被确定为不良预后因素.
■在伊朗APL患者中,BCR1占主导地位,虽然bcr3与较高的白细胞计数相关,高风险分类,额外的染色体异常,更快的CHR。生存受到老年的负面影响,复发,降低PLT计数,更高的白细胞计数,和白细胞增多。
UNASSIGNED: Acute Promyelocytic Leukemia (
APL) is a medical emergency with potentially fatal complications.
APL primarily results from a chromosomal translocation (t(15;17)(q22;q21)), leading to the formation of the PML-RARA fusion gene with three possible isoforms. This study aims to investigate the characteristics of Iranian
APL patients, the distribution of PML-RARA isoforms, and survival analysis.
UNASSIGNED: We included 145 consecutive eligible patients in this study. Data were collected through archived documents and phone inquiries, following consent. Subsequently, we analyzed the data using SPSS software version 26.0.
UNASSIGNED: We examined 75 men and 70 women, with a mean age of 34 years (range: 2-78 years). Besides t(15;17) (q22;q21), 45.6% had other chromosomal abnormalities. The prevalence of bcr1 and bcr3 isoforms was 73% and 27%, respectively. bcr3 correlated with higher white blood cell (WBC) counts, additional chromosomal abnormalities, and faster Complete Hematologic Response (CHR). Early death occurred in approximately 36% of all patients. The mean overall survival time was 73.5 months, with 120-month survival rates of 53.8% for all patients and 83.9% for those who achieved CHR. Univariate analysis identified old age, relapse, lower platelet (PLT) counts, higher WBC counts, and leukocytosis as survival risk factors. However, in multivariate analysis, only old age and higher WBC counts were identified as adverse prognostic factors.
UNASSIGNED: In Iranian
APL patients, bcr1 predominates, while bcr3 correlates with higher WBC counts, high-risk categorization, additional chromosomal abnormalities, and faster CHR. Survival is negatively impacted by old age, relapse, lower PLT counts, higher WBC counts, and leukocytosis.