未经证实:C反应蛋白(CRP)是狗全身性炎症的确定标记,尤其是在患有败血症的狗中升高。一些患有急性出血性腹泻综合征(AHDS)的狗在住院期间发生细菌移位和随后的败血症。这项研究旨在评估AHDS犬住院期间CRP血浆浓度的过程及其与临床和其他实验室变量的相关性。
未经批准:在此前瞻性中,观察性研究,在第0、1、2和3天,对27只患有AHDS的客户拥有的狗进行了CRP评估。临床检查数据,血压,急性患者生理和实验室评估(APPLE)全面和APPLE快速评分,并在同一天测量犬出血性腹泻严重程度(CHDS)指数以评估疾病的严重程度。
未经证实:27只狗中有25只出院。19只狗因败血症或中性粒细胞减少症接受了抗菌治疗。CRP值在第0天轻度升高(中位数27.3mg/L;1.0-125.8mg/L),在第1天明显升高(中位数88.9mg/L;1.4-192.7mg/L)。CRP浓度在随后的几天内逐渐降低。此外,CRP浓度与白蛋白中度相关,白细胞计数,中性粒细胞计数,和苹果的全分和快速,但没有抗菌治疗。
未经证实:AHDS患者的CRP浓度显著升高。在这项研究人群中,CRP无助于检测AHDS犬的抗菌治疗需求。然而,因为CRP可以监测对治疗的反应,定期分析可以指导治疗。
UNASSIGNED: C-reactive protein (CRP) is an established marker for systemic inflammation in dogs that is especially elevated in dogs with sepsis. Some dogs with acute hemorrhagic diarrhea syndrome (
AHDS) develop bacterial translocation and consequent sepsis during hospitalization. This study aimed to evaluate the course of CRP plasma concentrations during hospitalization and its correlation with clinical and other laboratory variables in dogs with
AHDS.
UNASSIGNED: In this prospective, observational study, CRP was evaluated on days 0, 1, 2, and 3 in 27 client-owned dogs who presented with
AHDS. Clinical examination data, blood pressure, acute patient physiologic and laboratory evaluation (APPLE) full and APPLE fast scores, and canine hemorrhagic diarrhea severity (CHDS) index were measured on the same days to evaluate the severity of the disease.
UNASSIGNED: Twenty-five of the 27 dogs were discharged from hospital. Nineteen dogs received antimicrobial treatment due to sepsis or neutropenia. CRP values were mildly elevated on day 0 (median 27.3 mg/L; 1.0-125.8 mg/L) and markedly elevated on day 1 (median 88.9 mg/L; 1.4-192.7 mg/L). CRP concentrations decreased gradually over the following days. Moreover, CRP concentrations correlated moderately with albumin, leucocyte count, neutrophil count, and APPLE full and fast scores, but not with antimicrobial treatment.
UNASSIGNED: CRP concentrations were significantly elevated in patients with
AHDS. In this study population, CRP did not help in detecting the requirement of antimicrobial treatment in dogs with
AHDS. Nevertheless, as CRP can monitor the response to treatment, regular analysis can guide treatment.