■可以在整个肿瘤中确定直方图,部分依赖于现有的肿瘤微观结构知识和感兴趣区域分析的采样效应。我们旨在研究ADC直方图参数在鉴别髓母细胞瘤中的影响,室管膜瘤,和毛细胞星形细胞瘤.
■本研究获得儿童医院伦理审查委员会的批准。过程是根据相关法律法规进行的,并满足书面知情同意书的要求.该研究涉及2019年2月至12月在儿童医院02的24名患者。第1组包括12名髓母细胞瘤儿童,第2组包括5例室管膜瘤,第3组包括7例毛细胞星形细胞瘤。所有患者均接受MRI检查,然后进行手术或活检以获得组织病理学确认。
■我们的分析表明AUC,灵敏度,特异性为96.7%,91.7%,100%,分别采用ADCkurtosis(截止点=2.34)来区分髓母细胞瘤和室管膜瘤。为了区分髓母细胞瘤和毛细胞星形细胞瘤,ADCmean的分界点,ADCmedian,ADCmax,ADCmin,rADCmean,rADCmax,与AUC分别取0.985、0.910、1.305、0.710、1.349、1.738和1.251的rADCmin,灵敏度,和特异性在100%引起。区分室管膜瘤和毛细胞星形细胞瘤,ADCmean的分界点,ADCmedian,ADCmax,ADCmin,rADCmean,rADC-中位数,rADCmax和rADCmin分别为1.010、0.930、1.270、0.735、1.346、1.324、1.676和1.273。AUC,灵敏度,和特异性为100%。
■ADC直方图可以促进青少年髓母细胞瘤的分化,室管膜瘤,毛细胞星形细胞瘤,提供可靠,肿瘤分化的客观证据。
UNASSIGNED: Histograms can be determined throughout tumors, relying partly on existing tumor microstructure knowledge and the sampling effect from area of interest analyses. We aimed to investigate the impact of ADC histogram parameters in discriminating medulloblastoma, ependymoma, and pilocytic astrocytoma.
UNASSIGNED: This study received approval from the Institutional Ethics Review Committee of Children\'s Hospital 02. Processes were conducted according to relevant laws and regulations, and requirements for written informed consent were fulfilled. The study involved 24 patients at Children\'s Hospital 02 from February-December 2019. Group 1 included 12 children with medulloblastoma, group 2 included 5 with ependymoma, and group 3 included 7 with pilocytic astrocytoma. All patients underwent MRI followed by surgery or biopsy to obtain histopathological confirmations.
UNASSIGNED: Our analysis indicated that AUC, sensitivity, and specificity were 96.7%, 91.7%, and 100%, respectively when ADCkurtosis (cut-off point = 2.34) was taken to differentiate between medulloblasto-mas and ependymomas. To distinguish between medulloblastomas and pilocytic astrocytomas, the cut-off points of ADCmean, ADCmedian, ADCmax, ADCmin, rADCmean, rADCmax, and rADCmin of 0.985, 0.910, 1.305, 0.710, 1.349, 1.738, and 1.251, were taken respectively with AUC, sensitivity, and specificity elicited at 100%. To discriminate between ependymomas and pilocytic astrocytomas, the cut-off points of ADCmean, ADCmedian, ADCmax, ADCmin, rADCmean, rADC-median, rADCmax and rADCmin were 1.010, 0.930, 1.270, 0.735, 1.346, 1.324, 1.676, and 1.273, respectively, with AUC, sensitivity, and specificity at 100%.
UNASSIGNED: ADC histograms can facilitate differentiation among juvenile medulloblastoma, ependymoma, and pilocytic astrocytoma, providing reliable, objective evidence of tumor differentiation.