UNASSIGNED:基于体素内不相干运动扩散加权成像(IVIM-DWI)和三维伪连续动脉自旋标记(3DpCASL)评估鼻咽癌(NPC)放化疗(CRT)的早期反应。
UNASSIGNED:纳入40例诊断为NPC的患者,在CRT后分为完全缓解(CR)和部分缓解(PR)组。所有患者均行IVIM和ASL,并获得相关参数。这些参数包括纯扩散系数(D),伪扩散系数(D*),灌注分数(f),平均血流量(BFavg),最小血流量(BFmin),和最大血流量(BFmax)。使用Studentt检验比较CR和PR之间ASL和IVIM衍生参数的差异。使用接受者工作特征(ROC)的曲线下面积(AUC)来分析ASL和IVIM的每个参数对治疗结果的诊断性能。
UNASSIGNED:CR组IVIM的D值低于PR组(P=0.014),.在ASL的参数中,CR组的BFavg和BFmax高于PR组(p=0.004,0.013),但两组BFmin差异无统计学意义(P=0.54)。D的AUC,BFavg,BFmax分别约为0.731、0.753和0.724,他们所有的联合AUC诊断为0.812.
UNASSIGNED:CRT后NPC的早期反应可以通过IVIM\的扩散参数和ASL相关的血流参数来预测。
UNASSIGNED: To evaluate the early response of chemoradiotherapy (CRT) in nasopharyngeal carcinoma (NPC) based on intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and three-dimensional pseudo-continuous arterial spin labeling (3D pCASL).
UNASSIGNED: Forty patients diagnosed with NPC were recruited and divided into complete remission (CR) and partial remission (PR) group after CRT. All patients underwent IVIM and ASL and the related parameters was obtained. These parameters include pure diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), average blood flow ( BFavg), minimum blood flow (BFmin), and maximum blood flow (BFmax). Student\'s t test was used to compare the difference in ASL and IVIM derived parameters between CR and PR. The Areas under curve (AUC) of the receiver operating characteristic (ROC) was used to analyze the diagnostic performance of each parameter of ASL and IVIM to the treatment outcome.
UNASSIGNED: the D value of IVIM in CR group was lower than that of the PR group ( P = 0.014),. Among the parameters of ASL, the BFavg and BFmax of the CR group were higher than those of the PR group(p = 0.004,0.013), but the BFmin had no statistical significance in the two groups(P = 0.54). AUC of D, BFavg, and BFmax is about 0.731, 0.753, and 0.724, respectively, all of their combined AUC diagnosis was 0.812.
UNASSIGNED: The early response of NPC after CRT can predict by IVIM\'s diffusion parameters and ASL-related blood flow parameters.