目的:父母在儿童心理病理学的发展中起着重要作用。在这项研究中,我们调查了父母精神病理学和行为在儿童脑症状网络中的作用,以了解精神病理学的代际传播的作用。很少有研究记录了儿童心理病理学的相互作用,父母的精神病理学,和儿童神经成像。
方法:我们利用青少年脑认知发展研究的基线队列(N=7,151,出生时女性=3,619,年龄9-11岁),使用儿童行为检查表和静息状态fMRI的稀疏典型相关分析得出脑症状网络。然后,我们将父母的精神病理学症状和父母的行为与儿童的大脑症状网络相关联。最后,我们使用显著的相关性来了解父母行为是否介导,使用中介R包,父母精神病理学对儿童大脑连通性的影响。
结果:我们观察到三个与外部化相关的大脑症状网络(r=.19,内化(r=.17),和神经发育症状(r=0.18)。这些对应于默认模式-默认模式之间的连接差异,默认模式控制,和视觉-视觉规范网络。我们进一步检测了父母精神病理学的各个方面,包括个人力量,思想问题,和规则破坏症状与儿童大脑连接有关。最后,我们发现父母的行为和症状可以调节彼此与儿童大脑连接的关系。
结论:当前的研究表明,积极的父母行为可以减轻父母精神病理学的潜在有害影响,反之亦然,与症状相关的儿童大脑连通性。总之,这些结果为未来的研究提供了框架,并为经历心理健康症状的父母提供了潜在的目标,以帮助减轻精神疾病的潜在代际传播.
OBJECTIVE: Parents play a notable role in the development of child psychopathology. In this study, we investigated the role of parent psychopathology and behaviors on child brain-symptom networks to understand the role of intergenerational transmission of psychopathology. Few studies have documented the interaction of child psychopathology, parent psychopathology, and child neuroimaging.
METHODS: We used the baseline cohort of the Adolescent Brain Cognitive Development Study (N = 7,151, female-at-birth = 3,619, aged 9-11 years) to derive brain-symptom networks using sparse canonical correlation analysis with the Child Behavior Checklist and resting-state functional magnetic resonance imaging. We then correlated parent psychopathology symptoms and parental behaviors with child brain-symptom networks. Finally, we used the significant correlations to understand, using the mediation R package, whether parent behaviors mediated the effect of parent psychopathology on child brain connectivity.
RESULTS: We observed 3 brain-symptom networks correlated with externalizing (r = 0.19, internalizing (r = 0.17), and neurodevelopmental symptoms (r = 0.18). These corresponded to differences in connectivity between the default mode-default mode, default mode-control, and visual-visual canonical networks. We further detected aspects of parental psychopathology, including personal strength, thought problems, and rule-breaking symptoms to be associated with child brain connectivity. Finally, we found that parental behaviors and symptoms mediate each other\'s relationship to child brain connectivity.
CONCLUSIONS: The current study suggests that positive parental behaviors can relieve potentially detrimental effects of parental psychopathology, and vice versa, on symptom-correlated child brain connectivity. Altogether, these results provide a framework for future research and potential targets for parents who experience mental health symptoms to help mitigate potential intergenerational transmission of mental illness.