近10年来,类器官技术得到了迅速发展,这涉及到发展机制的探索,再生和各种疾病,并在多个学科之间交叉。在细胞生物学组织工程的研究领域已经发表了成千上万的关于3D培养或类器官的文献,纳米科学,肿瘤学等等,导致研究人员及时总结这些研究具有挑战性。文献计量统计是帮助研究人员有效澄清上述问题并系统地管理整个景观的有用方法。在我们的研究中,2009年1月至2024年5月,所有关于类器官的原始文章都包含在WebofScience数据库中,并使用Excel软件收集和分析相关信息,R软件的“bibliometrix”软件包,VOSviewer和CiteSpace。作为结果,共纳入6222篇论文,对类器官的现状进行分类并预测未来的研究领域.我们的发现突出了与类器官相关的出版物的增长趋势,美国和荷兰在这一领域处于领先地位。加州大学系统,哈佛大学,乌得勒支大学和乌得勒支大学医学中心已成为关键贡献者,该领域的主要作者包括Clevers,H,Beekman,JM和SpenceJR.我们的研究结果还表明,类器官的研究热点和趋势主要集中在临床治疗,药物筛选,以及“水凝胶”和“微流体技术”等材料和技术在类器官中的应用。接下来,我们深入解读了类器官研究领域的发展过程,包括技术的出现,从长凳到床边的翻译,最广泛研究的类器官类型的概况,材料和技术的应用,以及新兴的类器官-免疫共培养趋势。此外,我们还讨论了陷阱,类器官技术的挑战和前景。总之,这项研究为读者提供了直接和方便的进入类器官研究领域。
Organoid technology has been developed rapidly in the past decade, which involves the exploration of the mechanism of development, regeneration and various diseases, and intersects among multiple disciplines. Thousands of literature on 3D-culture or organoids have been published in the research areas of cell biology tissue engineering, nanoscience, oncology and so on, resulting in it being challenging for researchers to timely summarize these studies. Bibliometric statistics is a helpful way to help researchers clarify the above issues efficiently and manage the whole landscape systematically. In our study, all original articles on organoids were included in the Web of Science database from January 2009 to May 2024, and related information was collected and analyzed using Excel software, \"bibliometrix\" packages of the R software, VOSviewer and CiteSpace. As results, a total of 6222 papers were included to classify the status quo of the organoids and predict future research areas. Our findings highlight a growing trend in publications related to organoids, with the United States and Netherlands leading in this field. The University of California System, Harvard University, Utrecht University and Utrecht University Medical Center have emerged as pivotal contributors and the key authors in the field include Clevers, H, Beekman, JM and Spence JR. Our results also revealed that the research hotspots and trends of organoids mainly focused on clinical treatment, drug screening, and the application of materials and technologies such as \"hydrogel\" and \"microfluidic technology\" in organoids. Next, we had an in-depth interpretation of the development process of organoid research area, including the emergence of technology, the translation from bench to bedsides, the profiles of the most widely studied types of organoids, the application of materials and technologies, and the emerging organoid-immune co-cultures trends. Furthermore, we also discussed the pitfalls, challenges and prospects of organoid technology. In conclusion, this study provides readers straightforward and convenient access to the organoid research field.