近年来,目前迫切需要设计和开发新型抗癌药物,这些药物可以减轻与目前使用的抗癌药物相关的严重健康问题和不良副作用。从对抗癌药物的各种研究和最新研究发现中可以看出,三唑核具有许多药理活性,包括抗癌。本文综述了1,2,3-三唑的抗癌潜力,1,2,4-三唑和杂环稠合三唑衍生物,特别是,1,2,3-三唑偶联齐墩果酸/二硫代氨基甲酸酯/吡啶并[2,3-d]嘧啶衍生物,1,2,3-三唑连接的嘧啶/1,4-萘醌杂化物和1,2,4-三唑取代的甲酮衍生物,吖啶基1,2,4-三唑衍生物,1,2,4-噻二唑偶联的1,2,4-三唑和5-烯-噻唑并[3,2-b][1,2,4]三唑-6(5H)-酮衍生物对几种人类癌细胞系,汇编2010年至2021年发表的研究文章。
In recent years, there has been a crucial need for the design and development of novel anticancer drugs which can lessen serious health problems and unwanted side effects associated with currently used anticancer drugs. Triazole nucleus is well-recognized to possess numerous pharmacological activities including anticancer as revealed from various investigations on anticancer drugs and latest research findings. This review provides an overview of anticancer potentiality of 1, 2, 3-triazole, 1, 2, 4-triazole and heterocycle-fused triazole derivatives, particularly, 1,2,3-triazole coupled oleanolic acid/ dithiocarbamate/ pyrido[2,3-d]pyrimidine derivatives, 1,2,3-triazole linked pyrimidine/1,4-naphthoquinone hybrids and 1,2,4-triazole substituted methanone derivatives, acridine-based 1,2,4-triazole derivatives, 1,2,4-thiadiazol coupled 1,2,4-triazole and 5-ene-thiazolo[3,2-b][1,2,4]triazole-6(5H)-one derivatives against several human cancer cell lines, compiling research articles published between 2010 and 2021.