Objective:To estimate the prevalence of amyotrophic lateral sclerosis (ALS) in the United States for 2017 using data from the National ALS Registry (Registry) as well as capture-recapture methodology to account for under-ascertainment. Established in 2010, the Registry collects and examines data on ALS patients in the US to better describe the epidemiology of ALS (i.e. risk factor exposures, demographics).Methods: The Registry compiled data from national administrative databases (from the Centers for Medicare and Medicaid Services, the Veterans Health Administration, and the Veterans Benefits Administration) and a voluntary enrollment data through a web portal (www.cdc.gov/als). To estimate the number of missing cases, capture-recapture methodology was utilized.Results: The Registry conservatively identified 17,800 adult persons (lower-bound estimate) who met the Registry definition of ALS for an age-adjusted prevalence of 5.5 per 100,000 US population. Using capture-recapture methodology, we obtained a \"mean case count\" of 24,821 ALS cases (prevalence of 7.7 per 100,000 U.S. population) and estimated the upper-bound estimate to be 31,843 cases (prevalence of 9.9 per 100,000 U.S. population). The pattern of patient characteristics (e.g. age, sex, and race/ethnicity) remained unchanged from previous Registry reports. Overall, ALS was most common among whites, males, and persons aged 60-69 years. The age groups with the lowest number of cases were persons aged 18-39 years. Males had a higher prevalence than females overall and across all data sources.Conclusions: Existing Registry methodology, along with capture-recapture methodology, are being used to better describe the epidemiology and demographics of ALS in the US.

Introduction. The morbidity and mortality rate of Acute Respiratory Tract Infection (ARI) in children under 5 is relatively high in Indonesia. Socio-demographic characteristic is considered one of the factors causing ARI in Indonesia. However, no study analyzed the prevalence of ARI among toddlers and the differences among the determinant factors in multiple periods. Thus, this study aimed to analyze the prevalence trends and determinant factors associated with ARI symptoms in children under 5 in Indonesia in 2007, 2012, and 2017. Methods. This study analyzed cross-sectional survey data from the Demographic and Health Survey (DHS) in Indonesia during 2007, 2012, and 2017. Bivariate and multivariate analysis with logistic regression was performed using Stata version 15. The final results were expressed in Adjusted Odds Ratio (AORs) and 95% Confidence Interval (CI). Results. The findings showed a progress in prevalence trends with a decrease in the percentage of children with ARI symptoms from 11.25% (2007), then 5.12% (2012) to 4.22% (2017). Risk factors for toddlers experiencing ARI symptoms were as follows: younger maternal age (OR: 1.13, 95% Cl 0.70-1.81 in 2007, OR: 1.72, 95% Cl 1.03-2.88 in 2012 and OR: 0.98, 95% Cl 0.48-1.97 in 2017), smoking habits of family members (OR: 1.12, 95% Cl 0.85-1.48 in 2012, OR: 1.23, 95% Cl in 2017), poor drinking water quality (OR: 1.12, 95% Cl 0.85-1.48 in 2012 and OR: 1.23, 95% Cl in 2017), unavailable toilet facilities (OR: 1.27, 95% Cl 1.04-1.56 in 2007, OR: 1.24, 95% Cl 0.95-1.63 in 2012 and OR: 1.28, 95% Cl 0.97-1.68 in 2017). Conclusion. There was a decrease in the prevalence of ARI symptoms among children in 2007, 2012, and 2017, with no prominent differences in other related factors. The lifestyle and household environmental factors such as the use of dirty fuel, the presence of smokers in the household, the poor quality of drinking water, unavailable toilet facilities in addition to the maternal age and child age were the determinant factors that must be prioritized and improved. Family self-awareness should also be enhanced for better prospects for toddler survival.

Increasing bacterial resistance to antibiotics is a worldwide ongoing issue. Urgent need for new antibacterial agents has resulted in significant research efforts, with new molecules proposed for use in clinical practice. However, as highlighted by many groups this process does not have an optimal rhythm and efficacy, to fully combat highly adaptive germs, particularly in the intensive care units. This review focuses on the last three years of novel FDA approved antibacterial agents (2015-2017): ceftazidime/avibactam, obiltoxaximab, bezlotoxu-mab, delafloxacin, meropenem/vaborbactam, ozenoxacin. Ceftazidime/avibactam and meropenem/ vaborbactam are new players in the field of resistant bacteria treatment. Ceftazidime/avibactam is validated in selected patients with complicated urinary or intra-abdominal infections, hospital and ventilator-associated pneumonia. Meropenem/ vaborbactam gained approval for the cases of complicated urinary tract infections. Other potential indications are under investigation, widened and validated by future studies. Obiltoxaximab is a monoclonal antibody that can be used in the prevention and treatment of inhalational anthrax. Bezlotoxumab monoclonal antibody is an useful and specific tool for the management of recurrent Clostridium difficile infection. Delafloxacin is approved for patients with acute skin or skin structure infections. Despite recent progress, it is imperative to continue the development of new antibiotic drugs and new strategies to counteract resistance to antibiotics.

To assess the epidemiological situation of giardiasis in Poland in 2017.
The assessment of the epidemiological situation of giardiasis in Poland was carried out on the basis of the results of the analysis of data from the annual bulletins “Infectious diseases and poisoning in Poland”, information from forms on individual cases provided by PSSE employees through the Epidemiological Case Reporting System (SRWE), information on outbreaks transferred by PSSE employees through the Registry of Epidemic Outbreaks (ROE), as well as data on deaths from the Department of Demographic Studies of the Central Statistical Office.
This is the first epidemiological report on giardiasis in Poland published in the epidemiological Chronicle. The number of new giardiasis cases registered in Poland in 2017 was 1 229 cases, incidence rate 3.2 per 100 000 population. Compared to previous years, the number of registered cases decreased. There were no deaths. Hospitalizations accounted for around 24.5% of all cases. All giardiasis cases met the criteria for the definition of a confirmed case. In 2017, there were 4 outbreaks of giardiasis.
The long-term decline in the number of cases and incidence in Poland indicates an improvement of the epidemiological situation. In comparison with epidemiological data for EU / EEA countries, Poland does not stand out significantly in terms of the number of cases, incidence or seasonality distribution of cases.

The aim of this article is to describe and assess changes in epidemiological situation of Hepatitis A in Poland in 2017.
The assessment was based on the information from the individual case questionnaires, aggregated data from the bulletins “Infectious diseases and poisonings in Poland in 2017” and reports from epidemiological investigations in outbreaks of hepatitis A, submitted by the sanitary-epidemiological stations to the Department of Epidemiology of Infectious Diseases and Surveillance in NIPH-NIH.
In 2017 a large increase of HAV cases and hepatitis A incidence was observed in Poland (3006 cases, incidence 7.8 per 100 000) in comparison to 2016 (35; 0.09). Majority of the cases were registered in large cities, where incidence was 3 times higher than in rural areas. Among reported there were 501 cases (16.6% of all cases) selfdeclaring as man who have sex with man (MSM). In course of the year an increasing trend in the number of cases was observed until September and the increase of male to female ratio (m/f) until May. Moreover 251 HAV outbreaks were reported, number of which increased until October and with the increase of m/f ratio in these outbreaks until April. From July to October there was an increase in the number of small outbreaks with m/f ratio equal 1. There were 178 imported cases reported, most of them from European countries- especially Germany and Spain.
In 2017 over 80-fold increase of HAV cases and hepatitis A incidence was observed in comparison to previous years. Available epidemiological data indicate that ongoing HAV outbreak among MSM in Europe reached also Poland, and data from the second part of the year suggest infection spreading in non-MSM part of the population. It is therefore highly indicated that the list of risk groups for which vaccination against hepatitis A is recommended should also be expanded for MSM. To avoid such increase in the number of cases in future it is recommended to introduce vaccinations in risk groups as soon as large international outbreak occurs.

The aim of the study is to assess the epidemiological situation of salmonellosis in 2017 in Poland compared to the previous years.
The assessment of the epidemiological situation was performed on the basis of data submitted to the Department of Epidemiology of Infectious Diseases and Surveillance NIPH-NIH by sanitaryepidemiological stations by means of the Epidemiological Case Reporting System (SRWE) and the Registry of Epidemic Outbreaks (ROE), along with data from the annual bulletin “Infectious diseases and poisonings in Poland in 2017” (NIPH-NIH, CSI, Warsaw 2018), and information from the laboratories of Sanitary epidemiological Stations as well as data from the Department of Demographic Studies of the Central Statistical Office.
In 2017, 10 000 cases of Salmonella infection were registered in Poland, 9 710 were cases of intestinal salmonellosis, 290 were forms of extraintestinal salmonellosis. The incidence rate per 100 thousand population was 26.0. The hospitalization rate for all salmonellosis cases was 63.3%. Confirmed cases accounted for 92,1% of all cases, the remaining 7.9% were probable cases. Peak incidence occurred, as in previous years, in the summer months. The voivodships with the largest number of cases caused by Salmonella were the Mazowieckie and Małopolskie voivodeships, the least was recorded in the Lubuskie voivodeship. The age group in which the highest percentage of food poisonings was recorded were children aged 0-4, while extraintestinal forms most often concerned people aged over 60. 278 food poisoning outbreaks were recorded, in which Salmonella Enteritidis was the most frequently isolated serotype. This serotype was most often isolated in foodborne outbreaks and in sporadic cases, it is responsible for 92% of all salmonellosis. Salmonella infection was found in 0.2% of people working with food and in 8.1% of contacts of the cases. According to data from the Central Statistical Office, 10 people died of salmonellosis in 2017.
In 2017, the number of people infected with Salmonella was as high as in 2016, the reason for the persistence of such a high number of cases may be the association of some infections with an international salmonellosis outbreak, the peak of which was in 2016. The high incidence of salmonellosis may also be a consequence of legal changes introduced in 2014 regarding the reporting of positive test results by laboratories for epidemiological surveillance.

The purpose of this study is to assess the epidemiological situation of food poisonings and infections in Poland in 2017.
The evaluation was based on the analysis of information sent to Department of Epidemiology NIPH-NIH through ROE (pol. Rejestr Ognisk Epidemicznych)- (an electronic system created for uploading, transfer and analysis of data acquired during the outbreak investigations). Additional sources for the analysis were NIPH-NIH annual bulletins (Czarkowski MP et al. “Infectious diseases and poisonings in Poland”, 2011-2017. Warsaw, NIPH-NIH and GIS).
In 2016 a total number of 926 foodborne infections and intoxications outbreaks were reported in which 27 702 persons were exposed and 7 416. A total number of 2 502 of patients were hospitalized. The most frequent etiological agent of outbreaks was hepatitis A virus (HAV) (27.1%). The most frequent cause of infection for all outbreaks cases was Salmonella sp. – 37.2%, especially serotype Enteritidis (32.2%). Among other agents rotaviruses caused 9.3% of outbreaks and noroviruses 14.5%. In 12.2% of outbreaks no etiological agent was found. The most frequent place of an outbreak was private household- 560 outbreaks (60.4%), and after that- hospital- 155 outbreaks (16.7%). In 86.8% of outbreaks no vehicle was found and in remaining the most frequent vehicle were eggs and egg products- 5.6% % of all outbreaks.
Increasing yearly trend of Salmonella Enteritidis outbreaks, and high proportion of eggs and egg products as vehicles in those outbreaks point towards necessity of microbiological surveillance enchantment in relation to abovementioned products. Dynamic increase in HAV outbreaks is a good example of how a pathogen with high epidemic potential could spread in susceptible population.

The aim of this study is to assess the epidemiological situation of foodborne botulism in Poland in 2017 compared to previous years.
The assessment is based on national surveillance data on foodborne botulism cases available in the annual bulletin “Infectious diseases and poisonings in Poland in 2017” and in previous publications, as well as data from botulism case reports for 2017 submitted by Sanitary-Epidemiological Stations to the Department of Epidemiology of Infectious Diseases and Surveillance NIPH-NIH.
In 2017, a total of 24 foodborne botulism cases have been reported including 14 with laboratory confirmation of botulism intoxication. The annual incidence rate (0.06 per 100,000 population) was one the lowest since the introduction of mandatory reporting of the disease in Poland. The highest incidence in the country was noted in Podlaskie (0.34). The incidence rate among rural residents (0.10 per 100,000 population) was more than twice as high as in urban areas (0.04). The incidence in men was 49% higher than in women. The disease was most common in middle-aged and elderly people; the highest incidence was noted in age group of 40-49 years (0.13) and 50-59 years (0.14). The most common sources of the toxin were homemade canned pork products as well as mixed or unknown types of canned meats. All patients were hospitalized. Four deaths related to the disease were reported.
In 2017, the overall number of reported cases continues to decrease. Limited number of laboratories performing laboratory diagnostics of botulism is still an issue. Additionally a priority remains to conduct health education with regard to safe food preservation, storage and consumption.

The aim of this study is to assess the epidemiological situation of campylobacteriosis in Poland in 2017 in comparison to previous years.
The evaluation is based on analysis of data from the annual bulletin “Infectious diseases and poisoning in Poland”, information from individual campylobacter case reports sent by local sanitary-epidemiological stations through the Electronic Registry of Epidemiological Forms (System Rejestracji Wywiadów Epidemiologicznych - SRWE), information on outbreaks shared through the Electronic Registry of Epidemic Outbreaks (Rejestr Ognisk Epidemicznych - ROE) and data on deaths from the Department of Demographic Studies of the Central Statistical Office.
There were 874 registered cases in Poland in 2017, all of them were confirmed cases. Incidence for Poland was 2.27/100 000 population. The highest incidence was observed in lubuskie voivodeship (7.57/100 000), małopolskie (4.64/100 000), śląskie (4.31/100 000) and warmińsko-mazurskie (3.48/100 000). In 2017 increasing trend of proportion of hospitalization was identified again. The rate was on 80% level. Campylobacter species was identified in 89% of all reported cases. Similarly to previous years, vast majority of cases was caused by Campylobacter jejuni - 91%. Among all reported cases, majority of them (72%, 629 cases) was identified in children aged 0-4. In 2017 one campylobacteriosis outbreak was reported.
Campylobacteriosis in Poland is still underreported and rarely diagnosed. Routine Campylobacter diagnosis is performed only by laboratories in small number of poviats which make it way harder to properly assess the campylobacteriosis epidemiological situation in Poland.

The aim of the study is to assess epidemiological situation of yersiniosis in Poland in 2017 in comparison to previous years.
The evaluation is based on analysis of data from the annual bulletins “Infectious diseases and poisoning in Poland”, information from individual yersiniosis case reports entered and shared by local sanitary-epidemiological stations through Electronic Registry of Epidemiologic Forms (SRWE), information from individual extraintestinal case reports fulfilled by local sanitary-epidemiological station and sent to the Departments of Epidemiology, National Institute of Public Health - National Institute of Hygiene by regional sanitary-epidemiological stations, information on outbreaks shared through the Electronic Registry of Epidemic Outbreaks (ROE) and data on deaths from the Department of Demographic Studies of the Central Statistical Office.
In 2017 255 cases of yersiniosis, including 191 intestinal and 64 extraintestinal were registered. Incidence in 2017 was 0.66/100 000 population. Number of cases registered in 2017 was higher than in 2015 and 2016 (for both years 205 cases with incidence 0.53/100 000 was observed) and similar to the one in 2014 (244 cases, incidence 0.63/100 000). In 2017 all intestinal yersiniosis cases met criteria for confirmed case. Around 35% of cases were registered in mazowieckie voivodship where incidence was similar to the one in European Union. Among Y. enterocolitica isolates, serotype was determined in 62 cases what stands for only 28.7% of all cases. Predominant serotype was 03, it was identified in 81% of serotyped cases. Most of intestinal yersiniosis cases occurred among children under 4 years (54.5% of all registered cases).
In 2017 increase in number of cases was observed. Yersiniosis in Poland is rarely diagnosed, incidence in Poland is more than twice time lower than in European Union.